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Amphiregulin (AREG)

AR; CRDGF; SDGF; Colorectum Cell-Derived Growth Factor; Schwannoma-Derived Growth Factor

SPN W699
HGNC 651
MGI 88068
PubMed 21562239
RGD 2149
UniProt P15514
Wiki Amphiregulin

Amphiregulin is a member of the EGF family of proteins. Amphiregulin is a major autocrine growth factor for cultured human keratinocytes and probably plays a role in the aberrant keratinocyte growth of hyperproliferative disorders.The protein encoded by this gene is a member of the epidermal growth factor family.

It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells, and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). This protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. This encoded protein is associated with a psoriasis-like skin phenotype.Amphiregulin, also known as AREG.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins W699Hu01 Recombinant Amphiregulin (AREG) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Amphiregulin (AREG) Bioactivity
Antibodies MW699Hu22 Monoclonal Antibody to Amphiregulin (AREG) WB; IHC; ICC; IP.
PW699Hu01 Polyclonal Antibody to Amphiregulin (AREG) WB; IHC; ICC; IF.
LW699Hu76 Biotin Linked-Polyclonal Antibody to Amphiregulin (AREG) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Amphiregulin (AREG) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Amphiregulin (AREG) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Amphiregulin (AREG) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Amphiregulin (AREG) Flow Cytometry;ICC/IF
Assay Kits KEW699Hu ELISA Kit for Amphiregulin (AREG) Enzyme-linked immunosorbent assay for Antigen Detection
KCW699Hu CLIA kit for Amphiregulin (AREG) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins W699Mu01 Recombinant Amphiregulin (AREG) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Amphiregulin (AREG) Bioactivity
Antibodies NONE Monoclonal Antibody to Amphiregulin (AREG) WB; IHC; ICC; IP.
PW699Mu01 Polyclonal Antibody to Amphiregulin (AREG) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Amphiregulin (AREG) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Amphiregulin (AREG) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Amphiregulin (AREG) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Amphiregulin (AREG) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Amphiregulin (AREG) Flow Cytometry;ICC/IF
Assay Kits KEW699Mu ELISA Kit for Amphiregulin (AREG) Enzyme-linked immunosorbent assay for Antigen Detection
KCW699Mu CLIA kit for Amphiregulin (AREG) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins W699Ra01 Recombinant Amphiregulin (AREG) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Amphiregulin (AREG) Bioactivity
Antibodies MW699Ra21 Monoclonal Antibody to Amphiregulin (AREG) WB; IHC; ICC; IP.
PW699Ra01 Polyclonal Antibody to Amphiregulin (AREG) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Amphiregulin (AREG) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Amphiregulin (AREG) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Amphiregulin (AREG) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Amphiregulin (AREG) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Amphiregulin (AREG) Flow Cytometry;ICC/IF
Assay Kits KEW699Ra ELISA Kit for Amphiregulin (AREG) Enzyme-linked immunosorbent assay for Antigen Detection
KCW699Ra CLIA kit for Amphiregulin (AREG) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Amphiregulin (AREG) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Amphiregulin (AREG) Bioactivity
Antibodies NONE Monoclonal Antibody to Amphiregulin (AREG) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Amphiregulin (AREG) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Amphiregulin (AREG) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Amphiregulin (AREG) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Amphiregulin (AREG) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Amphiregulin (AREG) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Amphiregulin (AREG) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Amphiregulin (AREG) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Amphiregulin (AREG) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins W699Po01 Recombinant Amphiregulin (AREG) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Amphiregulin (AREG) Bioactivity
Antibodies NONE Monoclonal Antibody to Amphiregulin (AREG) WB; IHC; ICC; IP.
PW699Po01 Polyclonal Antibody to Amphiregulin (AREG) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Amphiregulin (AREG) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Amphiregulin (AREG) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Amphiregulin (AREG) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Amphiregulin (AREG) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Amphiregulin (AREG) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Amphiregulin (AREG) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Amphiregulin (AREG) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins W699Bo01 Recombinant Amphiregulin (AREG) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Amphiregulin (AREG) Bioactivity
Antibodies MW699Bo21 Monoclonal Antibody to Amphiregulin (AREG) WB; IHC; ICC; IP.
PW699Bo01 Polyclonal Antibody to Amphiregulin (AREG) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Amphiregulin (AREG) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Amphiregulin (AREG) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Amphiregulin (AREG) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Amphiregulin (AREG) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Amphiregulin (AREG) Flow Cytometry;ICC/IF
Assay Kits KEW699Bo ELISA Kit for Amphiregulin (AREG) Enzyme-linked immunosorbent assay for Antigen Detection
KCW699Bo CLIA kit for Amphiregulin (AREG) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Amphiregulin (AREG) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Amphiregulin (AREG) Bioactivity
Antibodies NONE Monoclonal Antibody to Amphiregulin (AREG) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Amphiregulin (AREG) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Amphiregulin (AREG) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Amphiregulin (AREG) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Amphiregulin (AREG) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Amphiregulin (AREG) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Amphiregulin (AREG) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Amphiregulin (AREG) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Amphiregulin (AREG) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins W699Ga01 Recombinant Amphiregulin (AREG) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Amphiregulin (AREG) Bioactivity
Antibodies NONE Monoclonal Antibody to Amphiregulin (AREG) WB; IHC; ICC; IP.
PW699Ga01 Polyclonal Antibody to Amphiregulin (AREG) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Amphiregulin (AREG) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Amphiregulin (AREG) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Amphiregulin (AREG) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Amphiregulin (AREG) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Amphiregulin (AREG) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Amphiregulin (AREG) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Amphiregulin (AREG) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Amphiregulin (AREG) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Amphiregulin (AREG) Bioactivity
Antibodies NONE Monoclonal Antibody to Amphiregulin (AREG) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Amphiregulin (AREG) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Amphiregulin (AREG) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Amphiregulin (AREG) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Amphiregulin (AREG) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Amphiregulin (AREG) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Amphiregulin (AREG) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Amphiregulin (AREG) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Amphiregulin (AREG) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins W699Rb01 Recombinant Amphiregulin (AREG) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Amphiregulin (AREG) Bioactivity
Antibodies NONE Monoclonal Antibody to Amphiregulin (AREG) WB; IHC; ICC; IP.
PW699Rb51 Polyclonal Antibody to Amphiregulin (AREG) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Amphiregulin (AREG) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Amphiregulin (AREG) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Amphiregulin (AREG) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Amphiregulin (AREG) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Amphiregulin (AREG) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Amphiregulin (AREG) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Amphiregulin (AREG) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Amphiregulin (AREG) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Amphiregulin (AREG) Bioactivity
Antibodies NONE Monoclonal Antibody to Amphiregulin (AREG) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Amphiregulin (AREG) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Amphiregulin (AREG) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Amphiregulin (AREG) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Amphiregulin (AREG) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Amphiregulin (AREG) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Amphiregulin (AREG) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Amphiregulin (AREG) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Amphiregulin (AREG) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins W699Eq01 Recombinant Amphiregulin (AREG) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Amphiregulin (AREG) Bioactivity
Antibodies NONE Monoclonal Antibody to Amphiregulin (AREG) WB; IHC; ICC; IP.
PW699Eq01 Polyclonal Antibody to Amphiregulin (AREG) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Amphiregulin (AREG) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Amphiregulin (AREG) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Amphiregulin (AREG) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Amphiregulin (AREG) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Amphiregulin (AREG) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Amphiregulin (AREG) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Amphiregulin (AREG) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Amphiregulin (AREG) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Amphiregulin (AREG) Bioactivity
Antibodies NONE Monoclonal Antibody to Amphiregulin (AREG) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Amphiregulin (AREG) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Amphiregulin (AREG) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Amphiregulin (AREG) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Amphiregulin (AREG) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Amphiregulin (AREG) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Amphiregulin (AREG) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Amphiregulin (AREG) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Amphiregulin (AREG) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Amphiregulin (AREG) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Amphiregulin (AREG) Bioactivity
Antibodies NONE Monoclonal Antibody to Amphiregulin (AREG) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Amphiregulin (AREG) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Amphiregulin (AREG) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Amphiregulin (AREG) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Amphiregulin (AREG) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Amphiregulin (AREG) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Amphiregulin (AREG) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Amphiregulin (AREG) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Amphiregulin (AREG) CLIA assay for Antigen Detection

Reference

"The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity."
Mol. Cell. Biol. 10:1969-1981(1990) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Structure and function of human amphiregulin: a member of the epidermal growth factor family."
Science 243:1074-1076(1989) [PubMed] [Europe PMC] [Abstract]

"Amphiregulin: a bifunctional growth-modulating glycoprotein produced by the phorbol 12-myristate 13-acetate-treated human breast adenocarcinoma cell line MCF-7."
Proc. Natl. Acad. Sci. U.S.A. 85:6528-6532(1988) [PubMed] [Europe PMC] [Abstract]

"A heparin sulfate-regulated human keratinocyte autocrine factor is similar or identical to amphiregulin."
Mol. Cell. Biol. 11:2547-2557(1991) [PubMed] [Europe PMC] [Abstract]

"Colorectum cell-derived growth factor (CRDGF) is homologous to amphiregulin, a member of the epidermal growth factor family."
Growth Factors 7:195-205(1992) [PubMed] [Europe PMC] [Abstract]

"Clarification of the C-terminal proteolytic processing site of human Amphiregulin."
FEBS Lett. 586:3500-3502(2012) [PubMed] [Europe PMC] [Abstract]

"Amphiregulin induces tyrosine phosphorylation of the epidermal growth factor receptor and p185erbB2. Evidence that amphiregulin acts exclusively through the epidermal growth factor receptor at the surface of human epithelial cells."
J. Biol. Chem. 268:2924-2931(1993) [PubMed] [Europe PMC] [Abstract]

"Cornichon regulates transport and secretion of TGFalpha-related proteins in metazoan cells."
J. Cell Sci. 120:2454-2466(2007) [PubMed] [Europe PMC] [Abstract]

"Solution structure of the EGF-like domain from human amphiregulin."
Submitted (JAN-2009) to the PDB data bank

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