Connective Tissue Growth Factor (CTGF)

CCN2; HCS24; IGFBP8; NOV2; Insulin-Like Growth Factor-Binding Protein 8; Hypertrophic Chondrocyte-Specific Protein 24; CCN Family Member 2

SPN	W695
HGNC	2500
MGI	95537
PubMed	12134160
RGD	621392
UniProt	P29279
Wiki	CTGF

CTGF (connective tissue growth factor) is a cysteine-rich, matrix-associated, heparin-binding protein. In vitro, CTGF mirrors some of the effects of TGF beta on skin fibroblasts, such as stimulation of extracellular matrix production, chemotaxis, proliferation and integrin expression. CTGF can promote endothelial cell growth, migration, adhesion and survival and is thus implicated in endothelial cell function and angiogenesis.

CTGF binds to perlecan, a proteoglycan which has been localised in synovium, cartilage and numerous other tissues.CTGF has been implicated in extracellular matrix remodelling in wound healing, scleroderma and other fibrotic processes, as it is capable of upregulating both matrix metalloproteinases and their inhibitors.

Reference

"Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10."
J. Cell Biol. 114:1285-1294(1991) [PubMed] [Europe PMC] [Abstract]

"Connective tissue growth factor."
J. Dermatol. 19:642-643(1992) [PubMed] [Europe PMC] [Abstract]

"Human connective tissue growth factor is expressed in advanced atherosclerotic lesions."
Circulation 95:831-839(1997) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 6."
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

"Differential expression of novH and CTGF in human glioma cell lines."
Clin. Mol. Pathol. 49:91-97(1996)

"Identification of human CCN2 (connective tissue growth factor) promoter polymorphisms."
J. Clin. Pathol. 54:192-196(2001)

"Expression of a gene encoding a novel potential IGF binding protein in human tissues."
C. R. Acad. Sci. III, Sci. Vie 313:345-351(1991) [PubMed] [Europe PMC] [Abstract]

"Effects of CTGF/Hcs24, a product of a hypertrophic chondrocyte-specific gene, on the proliferation and differentiation of chondrocytes in culture."
Endocrinology 141:264-273(2000) [PubMed] [Europe PMC] [Abstract]

"The heparin-binding 10 kDa fragment of connective tissue growth factor (CTGF) containing module 4 alone stimulates cell adhesion."
J. Endocrinol. 176:R1-R7(2003) [PubMed] [Europe PMC] [Abstract]