Bone Morphogenetic Protein 2 (BMP2)

BMP2A; BMP-2A; Hemochromatosis Modifier

SPN	W693
HGNC	1069
MGI	88177
PubMed	14584895
RGD	2211
UniProt	P12643
Wiki	BMP2

Bone morphogenetic protein 2 or BMP-2 belongs to the TGF-β superfamily of proteins. BMP-2 like other bone morphogenetic proteins, plays an important role in the development of bone and cartilage. It is involved in the hedgehog pathway, TGF beta signaling pathway, and in cytokine-cytokine receptor interaction. It is involved also in cardiac cell differentiation and epithelial to mesenchymal transition. BMP-2 and BMP-7 are osteogenic BMPs: they have been demonstrated to potently induce osteoblast differentiation in a variety of cell types.

Bone morphogenetic protein 2 is shown to stimulate the production of bone and recombinant human protein (rhBMP-2) and is currently available for orthopaedic usage in the United States.

Reference

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"USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney."
Biochem. Biophys. Res. Commun. 316:490-500(2004) [PubMed] [Europe PMC] [Abstract]

"Posttranslational activation of bone morphogenetic protein 2 is mediated by proprotein convertase 6 during decidualization for pregnancy establishment."
Endocrinology 151:3909-3917(2010) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of human bone morphogenetic protein-2 at 2.7 A resolution."
J. Mol. Biol. 287:103-115(1999) [PubMed] [Europe PMC] [Abstract]