Interleukin 8 Receptor Alpha (IL8Ra)

CD181; CDw128a; CXCR1; CKR1; CMKAR1; IL8R1; IL8RBA; IL8-RA; Chemokine C-X-C motif Receptor 1; High Affinity Interleukin-8 Receptor A

SPN	W687
HGNC	6026
MGI	2448715
PubMed	8486366
RGD	2905
UniProt	P25024
Wiki	IL8RA

Interleukin 8 receptor, alpha is a chemokine receptor. IL8RA has also been designated CD181 and CXCR1. CXCR1 is now the IUPHAR Committee on Receptor Nomenclature and Drug Classification recommended name.
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36.

Reference

"Structure and functional expression of a human interleukin-8 receptor."
Science 253:1278-1280(1991) [PubMed] [Europe PMC] [Abstract]

"Molecular characterization of receptors for human interleukin-8, GRO/melanoma growth-stimulatory activity and neutrophil activating peptide-2."
Mol. Immunol. 30:359-367(1993) [PubMed] [Europe PMC] [Abstract]

"The high-affinity interleukin 8 receptor gene (IL8RA) maps to the 2q33-q36 region of the human genome: cloning of a pseudogene (IL8RBP) for the low-affinity receptor."
Genomics 16:248-251(1993) [PubMed] [Europe PMC] [Abstract]

"Comparison of the genomic organization and promoter function for human interleukin-8 receptors A and B."
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"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
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"Single nucleotide polymorphisms in the coding regions of human CXC-chemokine receptors CXCR1, CXCR2 and CXCR3."
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"Characterization of two high affinity human interleukin-8 receptors."
J. Biol. Chem. 267:16283-16287(1992) [PubMed] [Europe PMC] [Abstract]

"Structure of a CXC chemokine-receptor fragment in complex with interleukin-8."
Structure 7:157-168(1999) [PubMed] [Europe PMC] [Abstract]