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Erythropoietin (EPO)

EP; Epoetin; Erythropoetin; Hematopoietin; Hemopoietin

Erythropoietin is a glycoprotein hormone that controls erythropoiesis, or red blood cell production. It is a cytokine for erythrocyte (red blood cell) precursors in the bone marrow.Also called hematopoietin or hemopoietin, it is produced by the peritubular capillary endothelial cells in the kidney, and is the hormone that regulates red blood cell production.

It also has other known biological functions. For example, erythropoietin plays an important role in the brain's response to neuronal injury.EPO is also involved in the wound healing process.When exogenous EPO is used as a performance-enhancing drug, it is classified as an erythropoiesis-stimulating agent (ESA). Exogenous EPO can often be detected in blood, due to slight difference from the endogenous protein, for example in features of posttranslational modification.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW678Hu01 Recombinant Erythropoietin (EPO) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW678Hu01 Monoclonal Antibody to Erythropoietin (EPO) WB; IHC; ICC; IP.
PAW678Hu01 Polyclonal Antibody to Erythropoietin (EPO) WB; IHC; ICC; IF.
Assay Kits CLW678Hu01 CLIA Kit for Erythropoietin (EPO) CLIA assay for Antigen Detection
ELW678Hu01 ELISA Kit for Erythropoietin (EPO) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW678Mu01 Recombinant Erythropoietin (EPO) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW678Mu01 Monoclonal Antibody to Erythropoietin (EPO) WB; IHC; ICC; IP.
PAW678Mu01 Polyclonal Antibody to Erythropoietin (EPO) WB; IHC; ICC; IF.
Assay Kits CLW678Mu01 CLIA Kit for Erythropoietin (EPO) CLIA assay for Antigen Detection
ELW678Mu01 ELISA Kit for Erythropoietin (EPO) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW678Ra01 Recombinant Erythropoietin (EPO) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW678Ra01 Monoclonal Antibody to Erythropoietin (EPO) WB; IHC; ICC; IP.
PAW678Ra01 Polyclonal Antibody to Erythropoietin (EPO) WB; IHC; ICC; IF.
Assay Kits CLW678Ra01 CLIA Kit for Erythropoietin (EPO) CLIA assay for Antigen Detection
ELW678Ra01 ELISA Kit for Erythropoietin (EPO) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW678Ca01 Recombinant Erythropoietin (EPO) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW678Ca01 Monoclonal Antibody to Erythropoietin (EPO) WB; IHC; ICC; IP.
PAW678Ca01 Polyclonal Antibody to Erythropoietin (EPO) WB; IHC; ICC; IF.
Assay Kits CLW678Ca01 CLIA Kit for Erythropoietin (EPO) CLIA assay for Antigen Detection
ELW678Ca01 ELISA Kit for Erythropoietin (EPO) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW678Po01 Recombinant Erythropoietin (EPO) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW678Po01 Monoclonal Antibody to Erythropoietin (EPO) WB; IHC; ICC; IP.
PAW678Po01 Polyclonal Antibody to Erythropoietin (EPO) WB; IHC; ICC; IF.
Assay Kits CLW678Po01 CLIA Kit for Erythropoietin (EPO) CLIA assay for Antigen Detection
ELW678Po01 ELISA Kit for Erythropoietin (EPO) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW678Bo01 Recombinant Erythropoietin (EPO) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW678Bo01 Monoclonal Antibody to Erythropoietin (EPO) WB; IHC; ICC; IP.
PAW678Bo01 Polyclonal Antibody to Erythropoietin (EPO) WB; IHC; ICC; IF.
Assay Kits CLW678Bo01 CLIA Kit for Erythropoietin (EPO) CLIA assay for Antigen Detection
ELW678Bo01 ELISA Kit for Erythropoietin (EPO) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW678Rb01 Recombinant Erythropoietin (EPO) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW678Rb01 Monoclonal Antibody to Erythropoietin (EPO) WB; IHC; ICC; IP.
PAW678Rb01 Polyclonal Antibody to Erythropoietin (EPO) WB; IHC; ICC; IF.
Assay Kits CLW678Rb01 CLIA Kit for Erythropoietin (EPO) CLIA assay for Antigen Detection
ELW678Rb01 ELISA Kit for Erythropoietin (EPO) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW678Mo01 Recombinant Erythropoietin (EPO) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW678Mo01 Monoclonal Antibody to Erythropoietin (EPO) WB; IHC; ICC; IP.
PAW678Mo01 Polyclonal Antibody to Erythropoietin (EPO) WB; IHC; ICC; IF.
Assay Kits CLW678Mo01 CLIA Kit for Erythropoietin (EPO) CLIA assay for Antigen Detection
ELW678Mo01 ELISA Kit for Erythropoietin (EPO) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Isolation and characterization of genomic and cDNA clones of human erythropoietin."
Nature 313:806-810(1985) [PubMed] [Europe PMC] [Abstract]

"Cloning and expression of the human erythropoietin gene."
Proc. Natl. Acad. Sci. U.S.A. 82:7580-7584(1985) [PubMed] [Europe PMC] [Abstract]

"Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes."
Genome Res. 8:1060-1073(1998) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of human chromosome 7."
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Gene expression of mutant erythropoietin in hepatocellular carcinoma."
Biochem. Biophys. Res. Commun. 195:717-722(1993) [PubMed] [Europe PMC] [Abstract]

"Structural characterization of human erythropoietin."
J. Biol. Chem. 261:3116-3121(1986) [PubMed] [Europe PMC] [Abstract]

"Isolation of human erythropoietin with monoclonal antibodies."
J. Biol. Chem. 259:2707-2710(1984) [PubMed] [Europe PMC] [Abstract]

"Comparative study of the asparagine-linked sugar chains of human erythropoietins purified from urine and the culture medium of recombinant Chinese hamster ovary cells."
J. Biol. Chem. 263:3657-3663(1988) [PubMed] [Europe PMC] [Abstract]

"Site-specific glycosylation of human recombinant erythropoietin: analysis of glycopeptides or peptides at each glycosylation site by fast atom bombardment mass spectrometry."
Biochemistry 27:8618-8626(1988) [PubMed] [Europe PMC] [Abstract]

"Structures and functional roles of the sugar chains of human erythropoietins."
Glycobiology 1:337-346(1991) [PubMed] [Europe PMC] [Abstract]

"Sugar profiling proves that human serum erythropoietin differs from recombinant human erythropoietin."
Blood 98:3626-3634(2001) [PubMed] [Europe PMC] [Abstract]

"Efficiency of signalling through cytokine receptors depends critically on receptor orientation."
Nature 395:511-516(1998) [PubMed] [Europe PMC] [Abstract]

"NMR structure of human erythropoietin and a comparison with its receptor bound conformation."
Nat. Struct. Biol. 5:861-866(1998) [PubMed] [Europe PMC] [Abstract]

"Promoter polymorphism of the erythropoietin gene in severe diabetic eye and kidney complications."
Proc. Natl. Acad. Sci. U.S.A. 105:6998-7003(2008) [PubMed] [Europe PMC] [Abstract]