Factor Related Apoptosis Ligand (FASL)

CD178; CD95L; CD95-L; FASLG; FASLG; APT1LG1; APT1-LG1; TNFSF6; Fas Antigen Ligand; TNF Superfamily Member 6; Tumor Necrosis Factor(ligand)Superfamily,Member 6

SPN	W675
HGNC	11936
MGI	99255
PubMed	7530337
RGD	3880
UniProt	P48023
Wiki	Fas_ligand

Fas ligand is a type II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. The binding of Fas ligand with its receptor induces apoptosis. Fas ligand-receptor interactions play an important role in the regulation of the immune system and the progression of cancer.Fas ligand or FasL is a type II transmembrane protein.

Fas ligand is a homotrimeric protein and signals through trimerization of FasR, which spans the membrane of the "target" cell. This trimerization usually leads to apoptosis, or cell death.Soluble Fas ligand is generated by cleaving membrane-bound FasL at a conserved cleavage site by the external serine matrix metalloproteinase MMP-7. Soluble FasL is less active than their membrane-bound counterparts and do not induce receptor trimerization and DISC formation.

Reference

"Fas ligand mediates activation-induced cell death in human T lymphocytes."
J. Exp. Med. 181:71-77(1995) [PubMed] [Europe PMC] [Abstract]

"Human Fas ligand: gene structure, chromosomal location and species specificity."
Int. Immunol. 6:1567-1574(1994) [PubMed] [Europe PMC] [Abstract]

"Role of Fas ligand in apoptosis induced by hepatitis C virus infection."
Biochem. Biophys. Res. Commun. 204:468-474(1994) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Fas ligand mutation in a patient with systemic lupus erythematosus and lymphoproliferative disease."
J. Clin. Invest. 98:1107-1113(1996) [PubMed] [Europe PMC] [Abstract]

"Characterization of Fas (Apo-1, CD95)-Fas ligand interaction."
J. Biol. Chem. 272:18827-18833(1997) [PubMed] [Europe PMC] [Abstract]

"Downregulation of Fas ligand by shedding."
Nat. Med. 4:31-36(1998) [PubMed] [Europe PMC] [Abstract]

"The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells."
Cell Death Differ. 14:1678-1687(2007) [PubMed] [Europe PMC] [Abstract]

"Sorting of Fas ligand to secretory lysosomes is regulated by mono-ubiquitylation and phosphorylation."
J. Cell Sci. 120:191-199(2007) [PubMed] [Europe PMC] [Abstract]

"Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."
BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]