Fibroblast Growth Factor 6 (FGF6)

HBGF6; HST2; HST2 Oncogene; Heparin Secretory-Transforming Protein 2; Heparin-Binding Growth Factor 6

SPN	W671
HGNC	3684
MGI	95520
PubMed	15672378
RGD	620130
UniProt	P10767
Wiki	FGF6

Fibroblast growth factor 6 is a protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene displayed oncogenic transforming activity when transfected into mammalian cells.

The mouse homolog of this gene exhibits a restricted expression profile predominantly in the myogenic lineage, which suggested a role in muscle regeneration or differentiation.Marics et al. (1989) showed that the cloned normal FGF6 gene transformed mouse NIH 3T3 fibroblasts using both focus and tumorigenicity assays.

Reference

"Putative structure of the FGF6 gene product and role of the signal peptide."
Oncogene 6:1437-1444(1991) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Human hst-2 (FGF-6) oncogene: cDNA cloning and characterization."
Oncogene 7:303-309(1992) [PubMed] [Europe PMC] [Abstract]

"Characterization of the HST-related FGF.6 gene, a new member of the fibroblast growth factor gene family."
Oncogene 4:335-340(1989) [PubMed] [Europe PMC] [Abstract]

"Receptor specificity of the fibroblast growth factor family."
J. Biol. Chem. 271:15292-15297(1996) [PubMed] [Europe PMC] [Abstract]

"Fibroblast growth factor signalling: from development to cancer."
Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]