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Insulin Like Growth Factor Binding Protein 2 (IGFBP2)

IBP2; IGF-BP53

Insulin-like growth factor binding protein-2 (IGFBP-2) is one of six characterized IGFBPs which specifically bind and modulate the actions of IGF-I and IGF-II. The binding affinity of IGFBP-2 for IGF-II is estimated to be significantly higher than for IGF-I, suggesting a role in regulation of IGF-II action. Studies in the fetal sheep indicate that IGFBP-2 is produced in many tissues, apparently coincident with IGF-II expression.

Recent studies of serum IGFBP-2 levels have shown that, unlike for IGFBP-1, there is negligible variability during the day and, unlike IGFBP-1 and IGFBP-3, virtually no change during puberty. IGFBP-2 has also been identified in other body fluids such as cerebrospinal, amniotic and coelomic fluids, urine and seminal fluid.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW654Hu01 Recombinant Insulin Like Growth Factor Binding Protein 2 (IGFBP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW654Hu01 Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 2 (IGFBP2) WB; IHC; ICC; IP.
PAW654Hu01 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 2 (IGFBP2) WB; IHC; ICC; IF.
Assay Kits CLW654Hu01 CLIA Kit for Insulin Like Growth Factor Binding Protein 2 (IGFBP2) CLIA assay for Antigen Detection
ELW654Hu01 ELISA Kit for Insulin Like Growth Factor Binding Protein 2 (IGFBP2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW654Mu01 Recombinant Insulin Like Growth Factor Binding Protein 2 (IGFBP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW654Mu01 Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 2 (IGFBP2) WB; IHC; ICC; IP.
PAW654Mu01 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 2 (IGFBP2) WB; IHC; ICC; IF.
Assay Kits CLW654Mu01 CLIA Kit for Insulin Like Growth Factor Binding Protein 2 (IGFBP2) CLIA assay for Antigen Detection
ELW654Mu01 ELISA Kit for Insulin Like Growth Factor Binding Protein 2 (IGFBP2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW654Ra01 Recombinant Insulin Like Growth Factor Binding Protein 2 (IGFBP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW654Ra01 Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 2 (IGFBP2) WB; IHC; ICC; IP.
PAW654Ra01 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 2 (IGFBP2) WB; IHC; ICC; IF.
Assay Kits CLW654Ra01 CLIA Kit for Insulin Like Growth Factor Binding Protein 2 (IGFBP2) CLIA assay for Antigen Detection
ELW654Ra01 ELISA Kit for Insulin Like Growth Factor Binding Protein 2 (IGFBP2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW654Ca01 Recombinant Insulin Like Growth Factor Binding Protein 2 (IGFBP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW654Ca01 Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 2 (IGFBP2) WB; IHC; ICC; IP.
PAW654Ca01 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 2 (IGFBP2) WB; IHC; ICC; IF.
Assay Kits CLW654Ca01 CLIA Kit for Insulin Like Growth Factor Binding Protein 2 (IGFBP2) CLIA assay for Antigen Detection
ELW654Ca01 ELISA Kit for Insulin Like Growth Factor Binding Protein 2 (IGFBP2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW654Po01 Recombinant Insulin Like Growth Factor Binding Protein 2 (IGFBP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW654Po01 Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 2 (IGFBP2) WB; IHC; ICC; IP.
PAW654Po01 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 2 (IGFBP2) WB; IHC; ICC; IF.
Assay Kits CLW654Po01 CLIA Kit for Insulin Like Growth Factor Binding Protein 2 (IGFBP2) CLIA assay for Antigen Detection
ELW654Po01 ELISA Kit for Insulin Like Growth Factor Binding Protein 2 (IGFBP2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW654Bo01 Recombinant Insulin Like Growth Factor Binding Protein 2 (IGFBP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW654Bo01 Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 2 (IGFBP2) WB; IHC; ICC; IP.
PAW654Bo01 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 2 (IGFBP2) WB; IHC; ICC; IF.
Assay Kits CLW654Bo01 CLIA Kit for Insulin Like Growth Factor Binding Protein 2 (IGFBP2) CLIA assay for Antigen Detection
ELW654Bo01 ELISA Kit for Insulin Like Growth Factor Binding Protein 2 (IGFBP2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW654Rb01 Recombinant Insulin Like Growth Factor Binding Protein 2 (IGFBP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW654Rb01 Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 2 (IGFBP2) WB; IHC; ICC; IP.
PAW654Rb01 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 2 (IGFBP2) WB; IHC; ICC; IF.
Assay Kits CLW654Rb01 CLIA Kit for Insulin Like Growth Factor Binding Protein 2 (IGFBP2) CLIA assay for Antigen Detection
ELW654Rb01 ELISA Kit for Insulin Like Growth Factor Binding Protein 2 (IGFBP2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW654Mo01 Recombinant Insulin Like Growth Factor Binding Protein 2 (IGFBP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW654Mo01 Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 2 (IGFBP2) WB; IHC; ICC; IP.
PAW654Mo01 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 2 (IGFBP2) WB; IHC; ICC; IF.
Assay Kits CLW654Mo01 CLIA Kit for Insulin Like Growth Factor Binding Protein 2 (IGFBP2) CLIA assay for Antigen Detection
ELW654Mo01 ELISA Kit for Insulin Like Growth Factor Binding Protein 2 (IGFBP2) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Cloning, sequence analysis and expression of a cDNA encoding a novel insulin-like growth factor binding protein (IGFBP-2)."
EMBO J. 8:2497-2502(1989) [PubMed] [Europe PMC] [Abstract]

"Isolation from adult human serum of four insulin-like growth factor (IGF) binding proteins and molecular cloning of one of them that is increased by IGF I administration and in extrapancreatic tumor hypoglycemia."
J. Biol. Chem. 265:14892-14898(1990) [PubMed] [Europe PMC] [Abstract]

"Structure and localization of the human insulin-like growth factor-binding protein 2 gene."
Biochem. Biophys. Res. Commun. 176:1250-1255(1991) [PubMed] [Europe PMC] [Abstract]

"Sequence analysis, expression and chromosomal localization of a gene, isolated from a subtracted human retina cDNA library, that encodes an insulin-like growth factor binding protein (IGFBP2)."
Exp. Eye Res. 52:549-561(1991) [PubMed] [Europe PMC] [Abstract]

"Structure of the human insulin-like growth factor binding protein-2 gene."
Mol. Endocrinol. 6:826-836(1992) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Purification from human cerebrospinal fluid of insulin-like growth factor binding proteins (IGFBPs). Isolation of IGFBP-2, an altered form of IGFBP-3 and a new IGFBP species."
Growth Regul. 1:125-130(1991) [PubMed] [Europe PMC] [Abstract]

"Duplication of the IGFBP-2 gene in teleost fish: protein structure and functionality conservation and gene expression divergence."
PLoS ONE 3:E3926-E3926(2008) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Structure, dynamics and heparin binding of the C-terminal domain of insulin-like growth factor-binding protein-2 (IGFBP-2)."
J. Mol. Biol. 364:690-704(2006) [PubMed] [Europe PMC] [Abstract]