Interleukin 12B (IL12B)
p40; IL12-B; CLMF2; NKSF2; Natural Killer Cell Stimulatory Factor 2; Cytotoxic Lymphocyte Maturation Factor 2; Interleukin 23, P40 Subunit
IL12B, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | W649Hu01 | Recombinant Interleukin 12B (IL12B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Interleukin 12B (IL12B) | Bioactivity | |
| Antibodies | MW649Hu22 | Monoclonal Antibody to Interleukin 12B (IL12B) | WB; IHC; ICC; IP. |
| PW649Hu01 | Polyclonal Antibody to Interleukin 12B (IL12B) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEW649Hu | ELISA Kit for Interleukin 12B (IL12B) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Interleukin 12B (IL12B) | CLIA assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | W649Mu01 | Recombinant Interleukin 12B (IL12B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Interleukin 12B (IL12B) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Interleukin 12B (IL12B) | WB; IHC; ICC; IP. |
| PW649Mu01 | Polyclonal Antibody to Interleukin 12B (IL12B) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEW649Mu | ELISA Kit for Interleukin 12B (IL12B) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Interleukin 12B (IL12B) | CLIA assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | W649Ra01 | Recombinant Interleukin 12B (IL12B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Interleukin 12B (IL12B) | Bioactivity | |
| Antibodies | MW649Ra21 | Monoclonal Antibody to Interleukin 12B (IL12B) | WB; IHC; ICC; IP. |
| PW649Ra01 | Polyclonal Antibody to Interleukin 12B (IL12B) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEW649Ra | ELISA Kit for Interleukin 12B (IL12B) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Interleukin 12B (IL12B) | CLIA assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | W649Ca01 | Recombinant Interleukin 12B (IL12B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Interleukin 12B (IL12B) | Bioactivity | |
| Antibodies | MW649Ca21 | Monoclonal Antibody to Interleukin 12B (IL12B) | WB; IHC; ICC; IP. |
| PW649Ca01 | Polyclonal Antibody to Interleukin 12B (IL12B) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEW649Ca | ELISA Kit for Interleukin 12B (IL12B) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Interleukin 12B (IL12B) | CLIA assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | W649Po01 | Recombinant Interleukin 12B (IL12B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Interleukin 12B (IL12B) | Bioactivity | |
| Antibodies | MW649Po21 | Monoclonal Antibody to Interleukin 12B (IL12B) | WB; IHC; ICC; IP. |
| PW649Po01 | Polyclonal Antibody to Interleukin 12B (IL12B) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEW649Po | ELISA Kit for Interleukin 12B (IL12B) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Interleukin 12B (IL12B) | CLIA assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | W649Bo01 | Recombinant Interleukin 12B (IL12B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Interleukin 12B (IL12B) | Bioactivity | |
| Antibodies | MW649Bo21 | Monoclonal Antibody to Interleukin 12B (IL12B) | WB; IHC; ICC; IP. |
| PW649Bo01 | Polyclonal Antibody to Interleukin 12B (IL12B) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEW649Bo | ELISA Kit for Interleukin 12B (IL12B) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Interleukin 12B (IL12B) | CLIA assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Interleukin 12B (IL12B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Interleukin 12B (IL12B) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Interleukin 12B (IL12B) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Interleukin 12B (IL12B) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Interleukin 12B (IL12B) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Interleukin 12B (IL12B) | CLIA assay for Antigen Detection |
Organism species: Chicken (Gallus)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | W649Ga01 | Recombinant Interleukin 12B (IL12B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Interleukin 12B (IL12B) | Bioactivity | |
| Antibodies | MW649Ga21 | Monoclonal Antibody to Interleukin 12B (IL12B) | WB; IHC; ICC; IP. |
| PW649Ga01 | Polyclonal Antibody to Interleukin 12B (IL12B) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEW649Ga | ELISA Kit for Interleukin 12B (IL12B) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Interleukin 12B (IL12B) | CLIA assay for Antigen Detection |
Organism species: Ovis aries; Ovine (Sheep)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Interleukin 12B (IL12B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Interleukin 12B (IL12B) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Interleukin 12B (IL12B) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Interleukin 12B (IL12B) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Interleukin 12B (IL12B) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Interleukin 12B (IL12B) | CLIA assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Interleukin 12B (IL12B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Interleukin 12B (IL12B) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Interleukin 12B (IL12B) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Interleukin 12B (IL12B) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Interleukin 12B (IL12B) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Interleukin 12B (IL12B) | CLIA assay for Antigen Detection |
Organism species: Cavia (Guinea pig )
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | W649Gu01 | Recombinant Interleukin 12B (IL12B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Interleukin 12B (IL12B) | Bioactivity | |
| Antibodies | MW649Gu21 | Monoclonal Antibody to Interleukin 12B (IL12B) | WB; IHC; ICC; IP. |
| PW649Gu01 | Polyclonal Antibody to Interleukin 12B (IL12B) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEW649Gu | ELISA Kit for Interleukin 12B (IL12B) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Interleukin 12B (IL12B) | CLIA assay for Antigen Detection |
Organism species: Equus caballus; Equine (Horse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | W649Eq01 | Recombinant Interleukin 12B (IL12B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Interleukin 12B (IL12B) | Bioactivity | |
| Antibodies | MW649Eq21 | Monoclonal Antibody to Interleukin 12B (IL12B) | WB; IHC; ICC; IP. |
| PW649Eq01 | Polyclonal Antibody to Interleukin 12B (IL12B) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEW649Eq | ELISA Kit for Interleukin 12B (IL12B) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Interleukin 12B (IL12B) | CLIA assay for Antigen Detection |
Organism species: Capra hircus; Caprine (Goat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | W649Cp01 | Recombinant Interleukin 12B (IL12B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Interleukin 12B (IL12B) | Bioactivity | |
| Antibodies | MW649Cp21 | Monoclonal Antibody to Interleukin 12B (IL12B) | WB; IHC; ICC; IP. |
| PW649Cp01 | Polyclonal Antibody to Interleukin 12B (IL12B) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEW649Cp | ELISA Kit for Interleukin 12B (IL12B) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Interleukin 12B (IL12B) | CLIA assay for Antigen Detection |
Organism species: Pan-species (General)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Interleukin 12B (IL12B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Interleukin 12B (IL12B) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Interleukin 12B (IL12B) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Interleukin 12B (IL12B) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Interleukin 12B (IL12B) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Interleukin 12B (IL12B) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Interleukin 12B (IL12B) | CLIA assay for Antigen Detection |
Reference
"Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor."
Proc. Natl. Acad. Sci. U.S.A. 88:4143-4147(1991) [PubMed] [Europe PMC] [Abstract]
"Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells."
J. Immunol. 146:3074-3081(1991) [PubMed] [Europe PMC] [Abstract]
"Complete primary structure, chromosomal localization, and definition of polymorphisms of the gene encoding the human interleukin 12 p40 subunit."
Genes Immun. 1:515-520(2000) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells."
Proc. Natl. Acad. Sci. U.S.A. 87:6808-6812(1990) [PubMed] [Europe PMC] [Abstract]
"Homology of the p40 subunit of natural killer cell stimulatory factor (NKSF) with the extracellular domain of the interleukin-6 receptor."
Cell 66:9-10(1991) [PubMed] [Europe PMC] [Abstract]
"Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor alpha production."
J. Exp. Med. 181:537-546(1995) [PubMed] [Europe PMC] [Abstract]
"Recombinant human interleukin-12 is the second example of a C-mannosylated protein."
Glycobiology 9:435-441(1999) [PubMed] [Europe PMC] [Abstract]
"Inherited interleukin 12 deficiency in a child with bacille Calmette-Guerin and Salmonella enteritidis disseminated infection."
J. Clin. Invest. 102:2035-2040(1998) [PubMed] [Europe PMC] [Abstract]
"Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12."
Immunity 13:715-725(2000) [PubMed] [Europe PMC] [Abstract]
"Inherited interleukin-12 deficiency: IL12B genotype and clinical phenotype of 13 patients from six kindreds."
Am. J. Hum. Genet. 70:336-348(2002) [PubMed] [Europe PMC] [Abstract]
"Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis."
Hum. Genet. 122:201-206(2007) [PubMed] [Europe PMC] [Abstract]
"Genetic variants of the IL-23R pathway: association with psoriatic arthritis and psoriasis vulgaris, but no specific risk factor for arthritis."
J. Invest. Dermatol. 129:355-358(2009) [PubMed] [Europe PMC] [Abstract]
"Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12."
EMBO J. 19:3530-3541(2000) [PubMed] [Europe PMC] [Abstract]
"Crystal structures of the pro-inflammatory cytokine interleukin-23 and its complex with a high-affinity neutralizing antibody."
J. Mol. Biol. 382:942-955(2008) [PubMed] [Europe PMC] [Abstract]
"The structure of interleukin-23 reveals the molecular basis of p40 subunit sharing with interleukin-12."
J. Mol. Biol. 382:931-941(2008) [PubMed] [Europe PMC] [Abstract]