Interleukin 15 (IL15)
Interleukin 15 (IL-15) is a cytokine with structural similarity to IL-2 that is secreted by mononuclear phagocytes (and some other cells) following infection by virus(es). This cytokine induces cell proliferation of natural killer cells; cells of the innate immune system whose principal role is to kill virally infected cells.
The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukin 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW646Hu01 | Recombinant Interleukin 15 (IL15) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW646Hu01 | Monoclonal Antibody to Interleukin 15 (IL15) | WB; IHC; ICC; IP. |
| PAW646Hu01 | Polyclonal Antibody to Interleukin 15 (IL15) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW646Hu01 | CLIA Kit for Interleukin 15 (IL15) | CLIA assay for Antigen Detection |
| ELW646Hu01 | ELISA Kit for Interleukin 15 (IL15) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW646Mu01 | Recombinant Interleukin 15 (IL15) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW646Mu01 | Monoclonal Antibody to Interleukin 15 (IL15) | WB; IHC; ICC; IP. |
| PAW646Mu01 | Polyclonal Antibody to Interleukin 15 (IL15) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW646Mu01 | CLIA Kit for Interleukin 15 (IL15) | CLIA assay for Antigen Detection |
| ELW646Mu01 | ELISA Kit for Interleukin 15 (IL15) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW646Ra01 | Recombinant Interleukin 15 (IL15) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW646Ra01 | Monoclonal Antibody to Interleukin 15 (IL15) | WB; IHC; ICC; IP. |
| PAW646Ra01 | Polyclonal Antibody to Interleukin 15 (IL15) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW646Ra01 | CLIA Kit for Interleukin 15 (IL15) | CLIA assay for Antigen Detection |
| ELW646Ra01 | ELISA Kit for Interleukin 15 (IL15) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW646Ca01 | Recombinant Interleukin 15 (IL15) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW646Ca01 | Monoclonal Antibody to Interleukin 15 (IL15) | WB; IHC; ICC; IP. |
| PAW646Ca01 | Polyclonal Antibody to Interleukin 15 (IL15) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW646Ca01 | CLIA Kit for Interleukin 15 (IL15) | CLIA assay for Antigen Detection |
| ELW646Ca01 | ELISA Kit for Interleukin 15 (IL15) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW646Po01 | Recombinant Interleukin 15 (IL15) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW646Po01 | Monoclonal Antibody to Interleukin 15 (IL15) | WB; IHC; ICC; IP. |
| PAW646Po01 | Polyclonal Antibody to Interleukin 15 (IL15) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW646Po01 | CLIA Kit for Interleukin 15 (IL15) | CLIA assay for Antigen Detection |
| ELW646Po01 | ELISA Kit for Interleukin 15 (IL15) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW646Bo01 | Recombinant Interleukin 15 (IL15) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW646Bo01 | Monoclonal Antibody to Interleukin 15 (IL15) | WB; IHC; ICC; IP. |
| PAW646Bo01 | Polyclonal Antibody to Interleukin 15 (IL15) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW646Bo01 | CLIA Kit for Interleukin 15 (IL15) | CLIA assay for Antigen Detection |
| ELW646Bo01 | ELISA Kit for Interleukin 15 (IL15) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW646Rb01 | Recombinant Interleukin 15 (IL15) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW646Rb01 | Monoclonal Antibody to Interleukin 15 (IL15) | WB; IHC; ICC; IP. |
| PAW646Rb01 | Polyclonal Antibody to Interleukin 15 (IL15) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW646Rb01 | CLIA Kit for Interleukin 15 (IL15) | CLIA assay for Antigen Detection |
| ELW646Rb01 | ELISA Kit for Interleukin 15 (IL15) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW646Mo01 | Recombinant Interleukin 15 (IL15) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW646Mo01 | Monoclonal Antibody to Interleukin 15 (IL15) | WB; IHC; ICC; IP. |
| PAW646Mo01 | Polyclonal Antibody to Interleukin 15 (IL15) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW646Mo01 | CLIA Kit for Interleukin 15 (IL15) | CLIA assay for Antigen Detection |
| ELW646Mo01 | ELISA Kit for Interleukin 15 (IL15) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor."
Science 264:965-968(1994) [PubMed] [Europe PMC] [Abstract]
"Genomic sequence and chromosomal location of the human interleukin-15 gene (IL15)."
Cytokine 8:667-674(1996) [PubMed] [Europe PMC] [Abstract]
"Identification of a novel interleukin-15 (IL-15) transcript isoform generated by alternative splicing in human small cell lung cancer cell lines."
Oncogene 12:2187-2192(1996) [PubMed] [Europe PMC] [Abstract]
"Generation of secretable and nonsecretable interleukin 15 isoforms through alternate usage of signal peptides."
Proc. Natl. Acad. Sci. U.S.A. 94:14444-14449(1997) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Engineering a high-affinity anti-IL-15 antibody: crystal structure reveals an alpha-helix in VH CDR3 as key component of paratope."
J. Mol. Biol. 406:160-175(2011) [PubMed] [Europe PMC] [Abstract]