Interleukin 16 (IL16)
LCF; PrIL-16; Lymphocyte Chemoattractant Factor; Pro-Interleukin 16
IL-16 is constitutively expressed by both CD4+ and CD8+ T cells. Airway epithelium from asthmatics, eosinophils, and mast cells also produce IL-16, albeit only after stimulation.
In lymphocytes, IL-16 is generated as a precursor molecule which is enzymatically cleaved following stimulation with T-cell mitogens. IL-16 is a proinflammatory and immunomodulatory cytokine.
It is a potent chemoattractant for all CD4+ cells including T cells, monocytes, and eosinophils and, as such, has been identified at inflammatory sites characterized by infiltrating CD4+ cells.In addition to cell motility, IL-16 induces cell cycle progression and cytokine synthesis in CD4+ T cells.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW645Hu01 | Recombinant Interleukin 16 (IL16) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW645Hu01 | Monoclonal Antibody to Interleukin 16 (IL16) | WB; IHC; ICC; IP. |
| PAW645Hu01 | Polyclonal Antibody to Interleukin 16 (IL16) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW645Hu01 | CLIA Kit for Interleukin 16 (IL16) | CLIA assay for Antigen Detection |
| ELW645Hu01 | ELISA Kit for Interleukin 16 (IL16) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW645Mu01 | Recombinant Interleukin 16 (IL16) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW645Mu01 | Monoclonal Antibody to Interleukin 16 (IL16) | WB; IHC; ICC; IP. |
| PAW645Mu01 | Polyclonal Antibody to Interleukin 16 (IL16) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW645Mu01 | CLIA Kit for Interleukin 16 (IL16) | CLIA assay for Antigen Detection |
| ELW645Mu01 | ELISA Kit for Interleukin 16 (IL16) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW645Ra01 | Recombinant Interleukin 16 (IL16) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW645Ra01 | Monoclonal Antibody to Interleukin 16 (IL16) | WB; IHC; ICC; IP. |
| PAW645Ra01 | Polyclonal Antibody to Interleukin 16 (IL16) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW645Ra01 | CLIA Kit for Interleukin 16 (IL16) | CLIA assay for Antigen Detection |
| ELW645Ra01 | ELISA Kit for Interleukin 16 (IL16) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW645Ca01 | Recombinant Interleukin 16 (IL16) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW645Ca01 | Monoclonal Antibody to Interleukin 16 (IL16) | WB; IHC; ICC; IP. |
| PAW645Ca01 | Polyclonal Antibody to Interleukin 16 (IL16) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW645Ca01 | CLIA Kit for Interleukin 16 (IL16) | CLIA assay for Antigen Detection |
| ELW645Ca01 | ELISA Kit for Interleukin 16 (IL16) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW645Po01 | Recombinant Interleukin 16 (IL16) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW645Po01 | Monoclonal Antibody to Interleukin 16 (IL16) | WB; IHC; ICC; IP. |
| PAW645Po01 | Polyclonal Antibody to Interleukin 16 (IL16) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW645Po01 | CLIA Kit for Interleukin 16 (IL16) | CLIA assay for Antigen Detection |
| ELW645Po01 | ELISA Kit for Interleukin 16 (IL16) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW645Bo01 | Recombinant Interleukin 16 (IL16) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW645Bo01 | Monoclonal Antibody to Interleukin 16 (IL16) | WB; IHC; ICC; IP. |
| PAW645Bo01 | Polyclonal Antibody to Interleukin 16 (IL16) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW645Bo01 | CLIA Kit for Interleukin 16 (IL16) | CLIA assay for Antigen Detection |
| ELW645Bo01 | ELISA Kit for Interleukin 16 (IL16) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW645Rb01 | Recombinant Interleukin 16 (IL16) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW645Rb01 | Monoclonal Antibody to Interleukin 16 (IL16) | WB; IHC; ICC; IP. |
| PAW645Rb01 | Polyclonal Antibody to Interleukin 16 (IL16) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW645Rb01 | CLIA Kit for Interleukin 16 (IL16) | CLIA assay for Antigen Detection |
| ELW645Rb01 | ELISA Kit for Interleukin 16 (IL16) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW645Mo01 | Recombinant Interleukin 16 (IL16) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW645Mo01 | Monoclonal Antibody to Interleukin 16 (IL16) | WB; IHC; ICC; IP. |
| PAW645Mo01 | Polyclonal Antibody to Interleukin 16 (IL16) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW645Mo01 | CLIA Kit for Interleukin 16 (IL16) | CLIA assay for Antigen Detection |
| ELW645Mo01 | ELISA Kit for Interleukin 16 (IL16) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"PDZ domain-mediated interaction of interleukin-16 precursor proteins with myosin phosphatase targeting subunits."
J. Biol. Chem. 278:42190-42199(2003) [PubMed] [Europe PMC] [Abstract]
"Discovery of novel human transcript variants by analysis of intronic single-block EST with polyadenylation site."
BMC Genomics 10:518-518(2009) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"Analysis of the DNA sequence and duplication history of human chromosome 15."
Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"GA-binding protein factors, in concert with the coactivator CREB binding protein/p300, control the induction of the interleukin 16 promoter in T lymphocytes."
Proc. Natl. Acad. Sci. U.S.A. 96:1541-1546(1999) [PubMed] [Europe PMC] [Abstract]
"Interleukin-16 or not?"
Nature 381:30-30(1996) [PubMed] [Europe PMC] [Abstract]
"Molecular and functional analysis of a lymphocyte chemoattractant factor: association of biologic function with CD4 expression."
Proc. Natl. Acad. Sci. U.S.A. 91:5109-5113(1994) [PubMed] [Europe PMC] [Abstract]
"Cloning, expression and purification of human interleukin-16."
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 15:25-27(1999)
"Processing and activation of pro-interleukin-16 by caspase-3."
J. Biol. Chem. 273:1144-1149(1998) [PubMed] [Europe PMC] [Abstract]
"Nuclear translocation of the N-terminal prodomain of interleukin-16."
J. Biol. Chem. 276:1299-1303(2001) [PubMed] [Europe PMC] [Abstract]
"Gene regulation mediated by calcium signals in T lymphocytes."
Nat. Immunol. 2:316-324(2001) [PubMed] [Europe PMC] [Abstract]
"Prointerleukin-16 contains a functional CcN motif that regulates nuclear localization."
Biochemistry 41:14306-14312(2002) [PubMed] [Europe PMC] [Abstract]
"Binding of HTLV-1 tax oncoprotein to the precursor of interleukin-16, a T cell PDZ domain-containing protein."
Virology 306:60-67(2003) [PubMed] [Europe PMC] [Abstract]
"Nuclear pro-IL-16 regulation of T cell proliferation: p27(KIP1)-dependent G0/G1 arrest mediated by inhibition of Skp2 transcription."
J. Immunol. 172:1654-1660(2004) [PubMed] [Europe PMC] [Abstract]
"Pro-IL-16 recruits histone deacetylase 3 to the Skp2 core promoter through interaction with transcription factor GABP."
J. Immunol. 180:402-408(2008) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"Structure of interleukin 16 resembles a PDZ domain with an occluded peptide binding site."
Nat. Struct. Biol. 5:682-686(1998) [PubMed] [Europe PMC] [Abstract]
"Solution structures of the PDZ domain of human interleukin-16."
Submitted (NOV-2005) to the PDB data bank