Glial Fibrillary Acidic Protein (GFAP)
Intermediate Filament Protein
GFAP) is an intermediate filament (IF) protein that is found in glial cells such as astrocytes. It is closely related to its non-epithelial family members, vimentin, desmin, and peripherin, which are all involved in the structure and function of the cell’s cytoskeleton. GFAP helps to maintain astrocyte mechanical strength, as well as the shape of cells.GFAP is expressed in the central nervous system in astrocyte cells. It is involved in many cellular functioning processes, such as cell structure and movement, cell communication, and the functioning of the blood brain barrier.
The predicted amino acid sequence indicated that GFAP shares structural similarities--particularly in the central rod domain and to a lesser degree in the carboxyl-terminal domain--with other IF proteins found in nonepithelial cell types.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW639Hu01 | Recombinant Glial Fibrillary Acidic Protein (GFAP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW639Hu01 | Monoclonal Antibody to Glial Fibrillary Acidic Protein (GFAP) | WB; IHC; ICC; IP. |
| PAW639Hu01 | Polyclonal Antibody to Glial Fibrillary Acidic Protein (GFAP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW639Hu01 | CLIA Kit for Glial Fibrillary Acidic Protein (GFAP) | CLIA assay for Antigen Detection |
| ELW639Hu01 | ELISA Kit for Glial Fibrillary Acidic Protein (GFAP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW639Mu01 | Recombinant Glial Fibrillary Acidic Protein (GFAP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW639Mu01 | Monoclonal Antibody to Glial Fibrillary Acidic Protein (GFAP) | WB; IHC; ICC; IP. |
| PAW639Mu01 | Polyclonal Antibody to Glial Fibrillary Acidic Protein (GFAP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW639Mu01 | CLIA Kit for Glial Fibrillary Acidic Protein (GFAP) | CLIA assay for Antigen Detection |
| ELW639Mu01 | ELISA Kit for Glial Fibrillary Acidic Protein (GFAP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW639Ra01 | Recombinant Glial Fibrillary Acidic Protein (GFAP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW639Ra01 | Monoclonal Antibody to Glial Fibrillary Acidic Protein (GFAP) | WB; IHC; ICC; IP. |
| PAW639Ra01 | Polyclonal Antibody to Glial Fibrillary Acidic Protein (GFAP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW639Ra01 | CLIA Kit for Glial Fibrillary Acidic Protein (GFAP) | CLIA assay for Antigen Detection |
| ELW639Ra01 | ELISA Kit for Glial Fibrillary Acidic Protein (GFAP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW639Ca01 | Recombinant Glial Fibrillary Acidic Protein (GFAP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW639Ca01 | Monoclonal Antibody to Glial Fibrillary Acidic Protein (GFAP) | WB; IHC; ICC; IP. |
| PAW639Ca01 | Polyclonal Antibody to Glial Fibrillary Acidic Protein (GFAP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW639Ca01 | CLIA Kit for Glial Fibrillary Acidic Protein (GFAP) | CLIA assay for Antigen Detection |
| ELW639Ca01 | ELISA Kit for Glial Fibrillary Acidic Protein (GFAP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW639Po01 | Recombinant Glial Fibrillary Acidic Protein (GFAP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW639Po01 | Monoclonal Antibody to Glial Fibrillary Acidic Protein (GFAP) | WB; IHC; ICC; IP. |
| PAW639Po01 | Polyclonal Antibody to Glial Fibrillary Acidic Protein (GFAP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW639Po01 | CLIA Kit for Glial Fibrillary Acidic Protein (GFAP) | CLIA assay for Antigen Detection |
| ELW639Po01 | ELISA Kit for Glial Fibrillary Acidic Protein (GFAP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW639Bo01 | Recombinant Glial Fibrillary Acidic Protein (GFAP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW639Bo01 | Monoclonal Antibody to Glial Fibrillary Acidic Protein (GFAP) | WB; IHC; ICC; IP. |
| PAW639Bo01 | Polyclonal Antibody to Glial Fibrillary Acidic Protein (GFAP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW639Bo01 | CLIA Kit for Glial Fibrillary Acidic Protein (GFAP) | CLIA assay for Antigen Detection |
| ELW639Bo01 | ELISA Kit for Glial Fibrillary Acidic Protein (GFAP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW639Rb01 | Recombinant Glial Fibrillary Acidic Protein (GFAP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW639Rb01 | Monoclonal Antibody to Glial Fibrillary Acidic Protein (GFAP) | WB; IHC; ICC; IP. |
| PAW639Rb01 | Polyclonal Antibody to Glial Fibrillary Acidic Protein (GFAP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW639Rb01 | CLIA Kit for Glial Fibrillary Acidic Protein (GFAP) | CLIA assay for Antigen Detection |
| ELW639Rb01 | ELISA Kit for Glial Fibrillary Acidic Protein (GFAP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW639Mo01 | Recombinant Glial Fibrillary Acidic Protein (GFAP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW639Mo01 | Monoclonal Antibody to Glial Fibrillary Acidic Protein (GFAP) | WB; IHC; ICC; IP. |
| PAW639Mo01 | Polyclonal Antibody to Glial Fibrillary Acidic Protein (GFAP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW639Mo01 | CLIA Kit for Glial Fibrillary Acidic Protein (GFAP) | CLIA assay for Antigen Detection |
| ELW639Mo01 | ELISA Kit for Glial Fibrillary Acidic Protein (GFAP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Molecular cloning and primary structure of human glial fibrillary acidic protein."
Proc. Natl. Acad. Sci. U.S.A. 86:5178-5182(1989) [PubMed] [Europe PMC] [Abstract]
"Characterization of human cDNA and genomic clones for glial fibrillary acidic protein."
Brain Res. Mol. Brain Res. 7:277-286(1990) [PubMed] [Europe PMC] [Abstract]
"Human glial fibrillary acidic protein: complementary DNA cloning, chromosome localization, and messenger RNA expression in human glioma cell lines of various phenotypes."
Cancer Res. 51:1553-1560(1991) [PubMed] [Europe PMC] [Abstract]
"Human glial fibrillary acidic protein (GFAP): molecular cloning of the complete cDNA sequence and chromosomal localization (chromosome 17) of the GFAP gene."
Acta Neuropathol. 83:569-578(1992) [PubMed] [Europe PMC] [Abstract]
"Determination of the gene structure of human GFAP and absence of coding region mutations associated with frontotemporal dementia with parkinsonism linked to chromosome 17."
Genomics 51:152-154(1998) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
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"The full-ORF clone resource of the German cDNA consortium."
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"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
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"An RNA polymerase II promoter containing sequences upstream and downstream from the RNA startpoint that direct initiation of transcription from the same site."
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