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Interleukin 4 (IL4)

BSF1; BCGF1 ;B Cell Stimulatory Factor 1; Lymphocyte stimulatory factor 1; B Cell Growth Factor; Binetrakin; Pitrakinra

Interleukin 4 is a pleiotropic cytokine produced primarily by activated T lymphocytes,mast cells and basophils . IL-4 has multiple immune response-modulating functions on a variety of cell types.

It is an important modulator of the differentiation of precursor T helper cells to the Th2 subset that mediates humoral immunity and modulates antibody production. In addition, IL-4 has also been shown to have anti-tumor activity both in vivoand in vitro.The biological effects of IL-4 are mediated by specific cell surface receptor complexes. One type of functional IL-4 receptor complex consists of the IL-4-binding subunit and a second chain, designated the common c chain because it has also been identified as a component of the receptor complexes for IL-4, IL-7, IL-9 and IL-15.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW633Hu01 Recombinant Interleukin 4 (IL4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW633Hu01 Monoclonal Antibody to Interleukin 4 (IL4) WB; IHC; ICC; IP.
PAW633Hu01 Polyclonal Antibody to Interleukin 4 (IL4) WB; IHC; ICC; IF.
Assay Kits CLW633Hu01 CLIA Kit for Interleukin 4 (IL4) CLIA assay for Antigen Detection
ELW633Hu01 ELISA Kit for Interleukin 4 (IL4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW633Mu01 Recombinant Interleukin 4 (IL4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW633Mu01 Monoclonal Antibody to Interleukin 4 (IL4) WB; IHC; ICC; IP.
PAW633Mu01 Polyclonal Antibody to Interleukin 4 (IL4) WB; IHC; ICC; IF.
Assay Kits CLW633Mu01 CLIA Kit for Interleukin 4 (IL4) CLIA assay for Antigen Detection
ELW633Mu01 ELISA Kit for Interleukin 4 (IL4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW633Ra01 Recombinant Interleukin 4 (IL4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW633Ra01 Monoclonal Antibody to Interleukin 4 (IL4) WB; IHC; ICC; IP.
PAW633Ra01 Polyclonal Antibody to Interleukin 4 (IL4) WB; IHC; ICC; IF.
Assay Kits CLW633Ra01 CLIA Kit for Interleukin 4 (IL4) CLIA assay for Antigen Detection
ELW633Ra01 ELISA Kit for Interleukin 4 (IL4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW633Ca01 Recombinant Interleukin 4 (IL4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW633Ca01 Monoclonal Antibody to Interleukin 4 (IL4) WB; IHC; ICC; IP.
PAW633Ca01 Polyclonal Antibody to Interleukin 4 (IL4) WB; IHC; ICC; IF.
Assay Kits CLW633Ca01 CLIA Kit for Interleukin 4 (IL4) CLIA assay for Antigen Detection
ELW633Ca01 ELISA Kit for Interleukin 4 (IL4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW633Po01 Recombinant Interleukin 4 (IL4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW633Po01 Monoclonal Antibody to Interleukin 4 (IL4) WB; IHC; ICC; IP.
PAW633Po01 Polyclonal Antibody to Interleukin 4 (IL4) WB; IHC; ICC; IF.
Assay Kits CLW633Po01 CLIA Kit for Interleukin 4 (IL4) CLIA assay for Antigen Detection
ELW633Po01 ELISA Kit for Interleukin 4 (IL4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW633Bo01 Recombinant Interleukin 4 (IL4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW633Bo01 Monoclonal Antibody to Interleukin 4 (IL4) WB; IHC; ICC; IP.
PAW633Bo01 Polyclonal Antibody to Interleukin 4 (IL4) WB; IHC; ICC; IF.
Assay Kits CLW633Bo01 CLIA Kit for Interleukin 4 (IL4) CLIA assay for Antigen Detection
ELW633Bo01 ELISA Kit for Interleukin 4 (IL4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW633Rb01 Recombinant Interleukin 4 (IL4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW633Rb01 Monoclonal Antibody to Interleukin 4 (IL4) WB; IHC; ICC; IP.
PAW633Rb01 Polyclonal Antibody to Interleukin 4 (IL4) WB; IHC; ICC; IF.
Assay Kits CLW633Rb01 CLIA Kit for Interleukin 4 (IL4) CLIA assay for Antigen Detection
ELW633Rb01 ELISA Kit for Interleukin 4 (IL4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW633Mo01 Recombinant Interleukin 4 (IL4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW633Mo01 Monoclonal Antibody to Interleukin 4 (IL4) WB; IHC; ICC; IP.
PAW633Mo01 Polyclonal Antibody to Interleukin 4 (IL4) WB; IHC; ICC; IF.
Assay Kits CLW633Mo01 CLIA Kit for Interleukin 4 (IL4) CLIA assay for Antigen Detection
ELW633Mo01 ELISA Kit for Interleukin 4 (IL4) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

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Proc. Natl. Acad. Sci. U.S.A. 83:5894-5898(1986) [PubMed] [Europe PMC] [Abstract]

"Complete nucleotide sequence of the chromosomal gene for human IL-4 and its expression."
J. Immunol. 142:274-282(1989) [PubMed] [Europe PMC] [Abstract]

"An alternatively spliced interleukin 4 form in lymphoid cells."
Immunogenetics 41:57-57(1995) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The 5' region of the human interleukin 4 gene: structure and potential regulatory elements."
Nucleic Acids Res. 16:772-772(1988) [PubMed] [Europe PMC] [Abstract]

"Disulfide assignments in recombinant mouse and human interleukin 4."
Biochemistry 30:1515-1523(1991) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of recombinant human interleukin-4."
J. Biol. Chem. 267:20371-20376(1992) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of human recombinant interleukin-4 at 2.25-A resolution."
FEBS Lett. 309:59-64(1992) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface."
Cell 97:271-281(1999) [PubMed] [Europe PMC] [Abstract]

"Secondary structure and topology of human interleukin 4 in solution."
Biochemistry 30:11029-11035(1991) [PubMed] [Europe PMC] [Abstract]

"Human interleukin 4. The solution structure of a four-helix bundle protein."
J. Mol. Biol. 224:899-904(1992) [PubMed] [Europe PMC] [Abstract]

"1H, 15N, 13C, and 13CO assignments of human interleukin-4 using three-dimensional double- and triple-resonance heteronuclear magnetic resonance spectroscopy."
Biochemistry 31:4334-4346(1992) [PubMed] [Europe PMC] [Abstract]

"Determination of the secondary structure and folding topology of human interleukin-4 using three-dimensional heteronuclear magnetic resonance spectroscopy."
Biochemistry 31:4347-4353(1992) [PubMed] [Europe PMC] [Abstract]

"Three-dimensional solution structure of human interleukin-4 by multidimensional heteronuclear magnetic resonance spectroscopy."
Science 256:1673-1677(1992) [PubMed] [Europe PMC] [Abstract]

"Experimental and theoretical studies of the three-dimensional structure of human interleukin-4."
Proteins 11:111-119(1991) [PubMed] [Europe PMC] [Abstract]

"Aspects of receptor binding and signalling of interleukin-4 investigated by site-directed mutagenesis and NMR spectroscopy."
J. Mol. Biol. 237:423-436(1994) [PubMed] [Europe PMC] [Abstract]

"Comparison of four independently determined structures of human recombinant interleukin-4."
Nat. Struct. Biol. 1:301-310(1994) [PubMed] [Europe PMC] [Abstract]

"Polymorphism in the P-selectin and interleukin-4 genes as determinants of stroke: a population-based, prospective genetic analysis."
Hum. Mol. Genet. 13:389-396(2004) [PubMed] [Europe PMC] [Abstract]