Interleukin 6 (IL6)

MGI2-A; MGI2A; HGF; BSF2; HSF; IFNB2; B-Cell Stimulatory Factor-2; Hybridoma/Plasmacytoma Growth Factor; Hepatocyte Stimulating Factor; Cytotoxic T-Cell Differentiation Factor

SPN	W631
HGNC	6018
MGI	96559
PubMed	21296109
RGD	2901
UniProt	P05231
Wiki	Interleukin_6

IL-6 is a multifunctional protein produced by lymphoid and non-lymphoid cells, and by normal and transformed cells, including T cells, monocyte/macrophages, fibroblasts, hepatocytes, vascular endothelial cells, cardiac myxomas, bladder cell carcinomas, myelomas, astrogliomas and glioblastomas. The production of IL-6 in these various cells is regulated, either positively or negatively, by a variety of signals including mitogens, antigenic stimulation, lipopolysaccharides, IL-1, TNF, PDGF and viruses. On the basis of its various activities, IL-6 has also been called interferon-β2 (IFN-β2), 26 kDa protein, B-cell stimulatory factor-2 (BSF-2),　hybridoma/plasmacytoma growth factor, hepatocyte stimulating factor, cytotoxic T-cell differentiation factor, and macrophage-granulocyte inducing factor 2A (MGI-2A).

Reference

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Nature 324:73-76(1986) [PubMed] [Europe PMC] [Abstract]

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Behring Inst. Mitt. 83:40-47(1988) [PubMed] [Europe PMC] [Abstract]

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Zhonghua Zhong Liu Za Zhi 14:340-344(1992) [PubMed] [Europe PMC] [Abstract]

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"Evidence for the importance of a positive charge and an alpha-helical structure of the C-terminus for biological activity of human IL-6."
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J. Mol. Biol. 268:468-481(1997) [PubMed] [Europe PMC] [Abstract]

"1.9-A crystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling."
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"The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis."
J. Clin. Invest. 102:1369-1376(1998) [PubMed] [Europe PMC] [Abstract]

"An IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in men infected with human immunodeficiency virus."
Blood 96:2562-2567(2000) [PubMed] [Europe PMC] [Abstract]

"A nucleotide variant in the promoter region of the interleukin-6 gene associated with decreased bone mineral density."
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"Association of interleukin-6 promoter variant with bone mineral density in pre-menopausal women."
J. Hum. Genet. 48:243-248(2003) [PubMed] [Europe PMC] [Abstract]