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Leptin Receptor (LEPR)
Leptin Receptor (LEPR)
CD295; LEPR; OBR; LR
Leptin receptor functions as a receptor for the fat cell-specific hormone leptin. LEP-R has also been designated as CD295. After co-discovering the Leptin gene with Jeffrey Friedman et al. in 1994, which involved a reverse genetic/positional cloning strategy to clone ob and db, Rudolph Leibel, working with collaborators at Millennium Pharmaceuticals and colleague Streamson Chua, confirmed cloning of the leptin receptor by demonstrating that an apparent leptin receptor cloned from a choroid plexus library using leptin as ligand, mapped to a physical map that included db and fa. The leptin hormone regulates adipose-tissue mass through hypothalamus effects on fullness and energy use. It acts through the leptin receptor (LEP-R), a single-transmembrane-domain receptor of the cytokine receptor family.
Organism species: Homo sapiens (Human)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
W627Hu01
Recombinant Leptin Receptor (LEPR) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Leptin Receptor (LEPR) Bioactivity
Antibodies
MW627Hu22
Monoclonal Antibody to Leptin Receptor (LEPR) WB; IHC; ICC; IP.
PW627Hu01
Polyclonal Antibody to Leptin Receptor (LEPR) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Leptin Receptor (LEPR) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Leptin Receptor (LEPR) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Leptin Receptor (LEPR) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Leptin Receptor (LEPR) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Leptin Receptor (LEPR) Flow Cytometry;ICC/IF
Assay Kits
KEW627Hu
ELISA Kit for Leptin Receptor (LEPR) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Leptin Receptor (LEPR) CLIA assay for Antigen Detection
Organism species: Mus musculus (Mouse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
W627Mu01
Recombinant Leptin Receptor (LEPR) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Leptin Receptor (LEPR) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Leptin Receptor (LEPR) WB; IHC; ICC; IP.
PW627Mu01
Polyclonal Antibody to Leptin Receptor (LEPR) WB; IHC; ICC; IF.
LW627Mu71
Biotin Linked-Polyclonal Antibody to Leptin Receptor (LEPR) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Leptin Receptor (LEPR) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Leptin Receptor (LEPR) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Leptin Receptor (LEPR) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Leptin Receptor (LEPR) Flow Cytometry;ICC/IF
Assay Kits
KEW627Mu
ELISA Kit for Leptin Receptor (LEPR) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Leptin Receptor (LEPR) CLIA assay for Antigen Detection
Organism species: Rattus norvegicus (Rat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
W627Ra01
Recombinant Leptin Receptor (LEPR) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Leptin Receptor (LEPR) Bioactivity
Antibodies
MW627Ra21
Monoclonal Antibody to Leptin Receptor (LEPR) WB; IHC; ICC; IP.
PW627Ra01
Polyclonal Antibody to Leptin Receptor (LEPR) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Leptin Receptor (LEPR) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Leptin Receptor (LEPR) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Leptin Receptor (LEPR) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Leptin Receptor (LEPR) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Leptin Receptor (LEPR) Flow Cytometry;ICC/IF
Assay Kits
KEW627Ra
ELISA Kit for Leptin Receptor (LEPR) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Leptin Receptor (LEPR) CLIA assay for Antigen Detection
Organism species: Canis familiaris; Canine (Dog)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Leptin Receptor (LEPR) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Leptin Receptor (LEPR) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Leptin Receptor (LEPR) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Leptin Receptor (LEPR) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Leptin Receptor (LEPR) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Leptin Receptor (LEPR) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Leptin Receptor (LEPR) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Leptin Receptor (LEPR) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Leptin Receptor (LEPR) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Leptin Receptor (LEPR) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Leptin Receptor (LEPR) CLIA assay for Antigen Detection
Organism species: Sus scrofa; Porcine (Pig)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
W627Po01
Recombinant Leptin Receptor (LEPR) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Leptin Receptor (LEPR) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Leptin Receptor (LEPR) WB; IHC; ICC; IP.
PW627Po01
Polyclonal Antibody to Leptin Receptor (LEPR) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Leptin Receptor (LEPR) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Leptin Receptor (LEPR) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Leptin Receptor (LEPR) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Leptin Receptor (LEPR) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Leptin Receptor (LEPR) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Leptin Receptor (LEPR) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Leptin Receptor (LEPR) CLIA assay for Antigen Detection
Organism species: Bos taurus; Bovine (Cattle)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Leptin Receptor (LEPR) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Leptin Receptor (LEPR) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Leptin Receptor (LEPR) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Leptin Receptor (LEPR) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Leptin Receptor (LEPR) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Leptin Receptor (LEPR) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Leptin Receptor (LEPR) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Leptin Receptor (LEPR) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Leptin Receptor (LEPR) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Leptin Receptor (LEPR) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Leptin Receptor (LEPR) CLIA assay for Antigen Detection
Organism species: Rhesus monkey (Simian)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Leptin Receptor (LEPR) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Leptin Receptor (LEPR) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Leptin Receptor (LEPR) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Leptin Receptor (LEPR) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Leptin Receptor (LEPR) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Leptin Receptor (LEPR) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Leptin Receptor (LEPR) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Leptin Receptor (LEPR) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Leptin Receptor (LEPR) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Leptin Receptor (LEPR) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Leptin Receptor (LEPR) CLIA assay for Antigen Detection
Organism species: Chicken (Gallus)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Leptin Receptor (LEPR) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Leptin Receptor (LEPR) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Leptin Receptor (LEPR) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Leptin Receptor (LEPR) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Leptin Receptor (LEPR) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Leptin Receptor (LEPR) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Leptin Receptor (LEPR) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Leptin Receptor (LEPR) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Leptin Receptor (LEPR) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Leptin Receptor (LEPR) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Leptin Receptor (LEPR) CLIA assay for Antigen Detection
Organism species: Ovis aries; Ovine (Sheep)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Leptin Receptor (LEPR) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Leptin Receptor (LEPR) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Leptin Receptor (LEPR) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Leptin Receptor (LEPR) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Leptin Receptor (LEPR) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Leptin Receptor (LEPR) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Leptin Receptor (LEPR) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Leptin Receptor (LEPR) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Leptin Receptor (LEPR) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Leptin Receptor (LEPR) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Leptin Receptor (LEPR) CLIA assay for Antigen Detection
Organism species: Oryctolagus cuniculus (Rabbit)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Leptin Receptor (LEPR) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Leptin Receptor (LEPR) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Leptin Receptor (LEPR) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Leptin Receptor (LEPR) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Leptin Receptor (LEPR) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Leptin Receptor (LEPR) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Leptin Receptor (LEPR) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Leptin Receptor (LEPR) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Leptin Receptor (LEPR) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Leptin Receptor (LEPR) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Leptin Receptor (LEPR) CLIA assay for Antigen Detection
Organism species: Cavia (Guinea pig )
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Leptin Receptor (LEPR) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Leptin Receptor (LEPR) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Leptin Receptor (LEPR) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Leptin Receptor (LEPR) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Leptin Receptor (LEPR) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Leptin Receptor (LEPR) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Leptin Receptor (LEPR) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Leptin Receptor (LEPR) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Leptin Receptor (LEPR) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Leptin Receptor (LEPR) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Leptin Receptor (LEPR) CLIA assay for Antigen Detection
Organism species: Equus caballus; Equine (Horse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Leptin Receptor (LEPR) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Leptin Receptor (LEPR) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Leptin Receptor (LEPR) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Leptin Receptor (LEPR) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Leptin Receptor (LEPR) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Leptin Receptor (LEPR) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Leptin Receptor (LEPR) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Leptin Receptor (LEPR) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Leptin Receptor (LEPR) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Leptin Receptor (LEPR) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Leptin Receptor (LEPR) CLIA assay for Antigen Detection
Organism species: Capra hircus; Caprine (Goat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Leptin Receptor (LEPR) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Leptin Receptor (LEPR) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Leptin Receptor (LEPR) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Leptin Receptor (LEPR) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Leptin Receptor (LEPR) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Leptin Receptor (LEPR) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Leptin Receptor (LEPR) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Leptin Receptor (LEPR) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Leptin Receptor (LEPR) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Leptin Receptor (LEPR) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Leptin Receptor (LEPR) CLIA assay for Antigen Detection
Organism species: Pan-species (General)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Leptin Receptor (LEPR) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Leptin Receptor (LEPR) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Leptin Receptor (LEPR) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Leptin Receptor (LEPR) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Leptin Receptor (LEPR) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Leptin Receptor (LEPR) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Leptin Receptor (LEPR) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Leptin Receptor (LEPR) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Leptin Receptor (LEPR) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Leptin Receptor (LEPR) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Leptin Receptor (LEPR) CLIA assay for Antigen Detection
Reference
"Identification and expression cloning of a leptin receptor, OB-R." Cell 83:1263-1271(1995) [PubMed ] [Europe PMC ] [Abstract ]
"Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice." Cell 84:491-495(1996) [PubMed ] [Europe PMC ] [Abstract ]
"Abnormal splicing of the leptin receptor in diabetic mice." Nature 379:632-635(1996) [PubMed ] [Europe PMC ] [Abstract ]
"Novel B219/OB receptor isoforms: possible role of leptin in hematopoiesis and reproduction." Nat. Med. 2:585-589(1996) [PubMed ] [Europe PMC ] [Abstract ]
"Defective STAT signaling by the leptin receptor in diabetic mice." Proc. Natl. Acad. Sci. U.S.A. 93:6231-6235(1996) [PubMed ] [Europe PMC ] [Abstract ]
"Hyperleptinemia, leptin resistance, and polymorphic leptin receptor in the New Zealand obese mouse." Endocrinology 138:4234-4239(1997) [PubMed ] [Europe PMC ] [Abstract ]
"Fine structure of the murine leptin receptor gene: splice site suppression is required to form two alternatively spliced transcripts." Genomics 45:264-270(1997) [PubMed ] [Europe PMC ] [Abstract ]
"Hyperleptinemia and leptin receptor variant Asp600Asn in the obese, hyperinsulinemic KK mouse strain." J. Endocrinol. 21:337-345(1998) [PubMed ] [Europe PMC ] [Abstract ]
"Identification of the Y985 and Y1077 motifs as SOCS3 recruitment sites in the murine leptin receptor." FEBS Lett. 486:33-37(2000) [PubMed ] [Europe PMC ] [Abstract ]
"Activation of downstream signals by the long form of the leptin receptor." J. Biol. Chem. 275:14563-14572(2000) [PubMed ] [Europe PMC ] [Abstract ]
"SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985." J. Biol. Chem. 275:40649-40657(2000) [PubMed ] [Europe PMC ] [Abstract ]
"Regulation of Jak kinases by intracellular leptin receptor sequences." J. Biol. Chem. 277:41547-41555(2002) [PubMed ] [Europe PMC ] [Abstract ]
