Monocyte Chemotactic Protein 2 (MCP2)

CCL8; CCL-8; SCYA8; MCP-2; HC14; Chemokine C-C-Motif Ligand 8; Small Inducible Cytokine Subfamily A(Cys-Cys)Member 8; Monocyte Chemoattractant Protein 2

SPN	W622
HGNC	10635
MGI	101878
PubMed	9596781
UniProt	P80075
Wiki	CCL8

Chemokine (C-C motif) ligand 8 (CCL8) is a small cytokine belonging to the CC chemokine family that was once called monocyte chemotactic protein-2 (MCP-2).

The CCL8 protein is produced as a precursor containing 109 amino acids, which is cleaved to produce mature CCL8 containing 75 amino acids. MCP-2 is chemotactic for and activates a many different immune cells, including mast cells, eosinophils and basophils, (that are implicated in allergic responses), and monocytes, T cells, and NK cells that are involved in the inflammatory response. CCL8 elicits its effects by binding to several different cell surface receptors called chemokine receptors.These receptors include CCR1, CCR2B and CCR5.

Reference

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Genomics 40:323-331(1997) [PubMed] [Europe PMC] [Abstract]

"Human monocyte chemotactic protein-2: cDNA cloning and regulated expression of mRNA in mesenchymal cells."
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"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Cloning and expression of a gamma-interferon-inducible gene in monocytes: a new member of a cytokine gene family."
Int. Immunol. 1:388-397(1989) [PubMed] [Europe PMC] [Abstract]

"Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family."
J. Exp. Med. 176:59-65(1992) [PubMed] [Europe PMC] [Abstract]

"Structural characterization of a monomeric chemokine: monocyte chemoattractant protein-3."
FEBS Lett. 395:277-282(1996) [PubMed] [Europe PMC] [Abstract]

"Posttranslational modifications affect the activity of the human monocyte chemotactic proteins MCP-1 and MCP-2: identification of MCP-2(6-76) as a natural chemokine inhibitor."
J. Immunol. 160:4034-4041(1998) [PubMed] [Europe PMC] [Abstract]

"Complete crystal structure of monocyte chemotactic protein-2, a CC chemokine that interacts with multiple receptors."
Biochemistry 39:14075-14081(2000) [PubMed] [Europe PMC] [Abstract]