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Colony Stimulating Factor 1, Macrophage (MCSF)

CSF1; M-CSF; Lanimostim; Processed macrophage colony-stimulating factor 1

Colony-stimulating factors (CSFs) are secreted glycoproteins which bind to receptor proteins on the surfaces of hemopoietic stem cells and thereby activate intracellular signaling pathways which can cause the cells to proliferate and differentiate into a specific kind of blood cell. The substance which was found to stimulate formation of colonies of macrophages, for instance, was called macrophage colony-stimulating factor, and so on.

Macrophage Colony-stimulating factor is a secreted cytokine which influences hemopoietic stem cells to differentiate into macrophages or other related cell types.The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW620Hu01 Recombinant Colony Stimulating Factor 1, Macrophage (MCSF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW620Hu01 Monoclonal Antibody to Colony Stimulating Factor 1, Macrophage (MCSF) WB; IHC; ICC; IP.
PAW620Hu01 Polyclonal Antibody to Colony Stimulating Factor 1, Macrophage (MCSF) WB; IHC; ICC; IF.
Assay Kits CLW620Hu01 CLIA Kit for Colony Stimulating Factor 1, Macrophage (MCSF) CLIA assay for Antigen Detection
ELW620Hu01 ELISA Kit for Colony Stimulating Factor 1, Macrophage (MCSF) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW620Mu01 Recombinant Colony Stimulating Factor 1, Macrophage (MCSF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW620Mu01 Monoclonal Antibody to Colony Stimulating Factor 1, Macrophage (MCSF) WB; IHC; ICC; IP.
PAW620Mu01 Polyclonal Antibody to Colony Stimulating Factor 1, Macrophage (MCSF) WB; IHC; ICC; IF.
Assay Kits CLW620Mu01 CLIA Kit for Colony Stimulating Factor 1, Macrophage (MCSF) CLIA assay for Antigen Detection
ELW620Mu01 ELISA Kit for Colony Stimulating Factor 1, Macrophage (MCSF) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW620Ra01 Recombinant Colony Stimulating Factor 1, Macrophage (MCSF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW620Ra01 Monoclonal Antibody to Colony Stimulating Factor 1, Macrophage (MCSF) WB; IHC; ICC; IP.
PAW620Ra01 Polyclonal Antibody to Colony Stimulating Factor 1, Macrophage (MCSF) WB; IHC; ICC; IF.
Assay Kits CLW620Ra01 CLIA Kit for Colony Stimulating Factor 1, Macrophage (MCSF) CLIA assay for Antigen Detection
ELW620Ra01 ELISA Kit for Colony Stimulating Factor 1, Macrophage (MCSF) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW620Ca01 Recombinant Colony Stimulating Factor 1, Macrophage (MCSF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW620Ca01 Monoclonal Antibody to Colony Stimulating Factor 1, Macrophage (MCSF) WB; IHC; ICC; IP.
PAW620Ca01 Polyclonal Antibody to Colony Stimulating Factor 1, Macrophage (MCSF) WB; IHC; ICC; IF.
Assay Kits CLW620Ca01 CLIA Kit for Colony Stimulating Factor 1, Macrophage (MCSF) CLIA assay for Antigen Detection
ELW620Ca01 ELISA Kit for Colony Stimulating Factor 1, Macrophage (MCSF) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW620Po01 Recombinant Colony Stimulating Factor 1, Macrophage (MCSF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW620Po01 Monoclonal Antibody to Colony Stimulating Factor 1, Macrophage (MCSF) WB; IHC; ICC; IP.
PAW620Po01 Polyclonal Antibody to Colony Stimulating Factor 1, Macrophage (MCSF) WB; IHC; ICC; IF.
Assay Kits CLW620Po01 CLIA Kit for Colony Stimulating Factor 1, Macrophage (MCSF) CLIA assay for Antigen Detection
ELW620Po01 ELISA Kit for Colony Stimulating Factor 1, Macrophage (MCSF) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW620Bo01 Recombinant Colony Stimulating Factor 1, Macrophage (MCSF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW620Bo01 Monoclonal Antibody to Colony Stimulating Factor 1, Macrophage (MCSF) WB; IHC; ICC; IP.
PAW620Bo01 Polyclonal Antibody to Colony Stimulating Factor 1, Macrophage (MCSF) WB; IHC; ICC; IF.
Assay Kits CLW620Bo01 CLIA Kit for Colony Stimulating Factor 1, Macrophage (MCSF) CLIA assay for Antigen Detection
ELW620Bo01 ELISA Kit for Colony Stimulating Factor 1, Macrophage (MCSF) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW620Rb01 Recombinant Colony Stimulating Factor 1, Macrophage (MCSF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW620Rb01 Monoclonal Antibody to Colony Stimulating Factor 1, Macrophage (MCSF) WB; IHC; ICC; IP.
PAW620Rb01 Polyclonal Antibody to Colony Stimulating Factor 1, Macrophage (MCSF) WB; IHC; ICC; IF.
Assay Kits CLW620Rb01 CLIA Kit for Colony Stimulating Factor 1, Macrophage (MCSF) CLIA assay for Antigen Detection
ELW620Rb01 ELISA Kit for Colony Stimulating Factor 1, Macrophage (MCSF) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW620Mo01 Recombinant Colony Stimulating Factor 1, Macrophage (MCSF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW620Mo01 Monoclonal Antibody to Colony Stimulating Factor 1, Macrophage (MCSF) WB; IHC; ICC; IP.
PAW620Mo01 Polyclonal Antibody to Colony Stimulating Factor 1, Macrophage (MCSF) WB; IHC; ICC; IF.
Assay Kits CLW620Mo01 CLIA Kit for Colony Stimulating Factor 1, Macrophage (MCSF) CLIA assay for Antigen Detection
ELW620Mo01 ELISA Kit for Colony Stimulating Factor 1, Macrophage (MCSF) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

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Science 230:291-296(1985) [PubMed] [Europe PMC] [Abstract]

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Mol. Immunol. 25:761-770(1988) [PubMed] [Europe PMC] [Abstract]

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"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
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"Expression of colony-stimulating factor-1 (CSF-1) messenger RNA in human endometrial glands during the menstrual cycle: molecular cloning of a novel transcript that predicts a cell surface form of CSF-1."
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"The structure of recombinant human carboxy-terminal-truncated macrophage colony-stimulating factor derived from mammalian cells."
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"Macrophage colony-stimulating factor purified from normal human urine. Amino-terminal sequence and amino acid composition."
FEBS Lett. 222:341-344(1987) [PubMed] [Europe PMC] [Abstract]

"Macrophage colony-stimulating factor is produced by human T lymphoblastoid cell line, CEM-ON: identification by amino-terminal amino acid sequence analysis."
Biochem. Biophys. Res. Commun. 152:1401-1409(1988) [PubMed] [Europe PMC] [Abstract]

"Synthesis of membrane-bound colony-stimulating factor 1 (CSF-1) and downmodulation of CSF-1 receptors in NIH 3T3 cells transformed by cotransfection of the human CSF-1 and c-fms (CSF-1 receptor) genes."
Mol. Cell. Biol. 7:2378-2387(1987) [PubMed] [Europe PMC] [Abstract]

"Differential processing of colony-stimulating factor 1 precursors encoded by two human cDNAs."
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"Identification of a high molecular weight macrophage colony-stimulating factor as a glycosaminoglycan-containing species."
J. Biol. Chem. 267:4345-4348(1992) [PubMed] [Europe PMC] [Abstract]

"Assignment of the inter- and intramolecular disulfide linkages in recombinant human macrophage colony stimulating factor using fast atom bombardment mass spectrometry."
Biochemistry 32:482-488(1993) [PubMed] [Europe PMC] [Abstract]

"CSF-1 regulation of the wandering macrophage: complexity in action."
Trends Cell Biol. 14:628-638(2004) [PubMed] [Europe PMC] [Abstract]

"Colony-stimulating factor-1 in immunity and inflammation."
Curr. Opin. Immunol. 18:39-48(2006) [PubMed] [Europe PMC] [Abstract]

"Macrophage colony stimulating factor: not just for macrophages anymore! A gateway into complex biologies."
Int. Immunopharmacol. 8:1354-1376(2008) [PubMed] [Europe PMC] [Abstract]

"Invasion of human breast cancer cells in vivo requires both paracrine and autocrine loops involving the colony-stimulating factor-1 receptor."
Cancer Res. 69:9498-9506(2009) [PubMed] [Europe PMC] [Abstract]

"Macrophage-colony stimulating factor and interleukin-34 induce chemokines in human whole blood."
Cytokine 52:215-220(2010) [PubMed] [Europe PMC] [Abstract]

"Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells."
J. Leukoc. Biol. 88:495-505(2010) [PubMed] [Europe PMC] [Abstract]

"Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."
Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]

"LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins."
J. Proteome Res. 12:573-584(2013) [PubMed] [Europe PMC] [Abstract]

"Three-dimensional structure of dimeric human recombinant macrophage colony-stimulating factor."
Science 258:1358-1362(1992) [PubMed] [Europe PMC] [Abstract]