Macrophage Inflammatory Protein 1 Beta (MIP1b)

CCL4; ACT2; G-26; LAG1; MIP1-B; SCYA4; Chemokine C-C-Motif Ligand 4; Small Inducible Cytokine A4; Homologous To Mouse Mip-1b

SPN	W617
HGNC	10630
MGI	98261
PubMed	17327452
RGD	620441
UniProt	P13236
Wiki	CCL4

The two variants of the Macrophage Inflammatory Protein 1, designated MIP-1α and MIP-1β, belong to the β or CC chemokine subfamily. The two chemokines were originally purified from lipopolysaccharidetreated murine monocytic cell lines, hence their designation as "Macrophage Inflammatory Protein". MIP-1α and MIP-1β are produced by stimulated leukocytes as well as other tissue cells and tumor cells. At least seven variants of rat MIP-1β, corresponding to the products of independantly cloned cDNA, including Act-2, G-26, HC-21, HIMAP, H400, pAT 744 and MAD-5, have been described. At the protein levels, mature rat MIP-1β has a length of 69 amino acids and shows a homology of 70% with MIP-1α. MIP-1β is a natural ligand for the chemokine receptors CCR3, CCR5 and CCR8.

Reference

"Identification, cloning, and characterization of an immune activation gene."
Proc. Natl. Acad. Sci. U.S.A. 85:9704-9708(1988) [PubMed] [Europe PMC] [Abstract]

"Mitogenic activation of human T cells induces two closely related genes which share structural similarities with a new family of secreted factors."
J. Immunol. 142:1582-1590(1989) [PubMed] [Europe PMC] [Abstract]

"A family of small inducible proteins secreted by leukocytes are members of a new superfamily that includes leukocyte and fibroblast-derived inflammatory agents, growth factors, and indicators of various activation processes."
J. Immunol. 142:679-687(1989) [PubMed] [Europe PMC] [Abstract]

"Cloning and expression of a lymphocyte activation gene (LAG-1)."
Mol. Immunol. 27:1091-1102(1990) [PubMed] [Europe PMC] [Abstract]

"Isolation and characterization of a cDNA encoding a putative cytokine which is induced by stimulation via the CD2 structure on human T lymphocytes."
Eur. J. Immunol. 19:1045-1051(1989) [PubMed] [Europe PMC] [Abstract]

"The gene encoding the Act-2 cytokine. Genomic structure, HTLV-I/Tax responsiveness of 5' upstream sequences, and chromosomal localization."
J. Biol. Chem. 266:17531-17536(1991) [PubMed] [Europe PMC] [Abstract]

"Multiple products derived from two CCL4 loci: high incidence of a new polymorphism in HIV+ patients."
J. Immunol. 174:5655-5664(2005) [PubMed] [Europe PMC] [Abstract]

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"A novel polypeptide secreted by activated human T lymphocytes."
J. Immunol. 143:2907-2916(1989) [PubMed] [Europe PMC] [Abstract]

"Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor."
Eur. J. Immunol. 28:582-588(1998) [PubMed] [Europe PMC] [Abstract]

"Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells."
Science 270:1811-1815(1995) [PubMed] [Europe PMC] [Abstract]

"The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8."
Eur. J. Immunol. 29:3210-3215(1999) [PubMed] [Europe PMC] [Abstract]

"Natural truncation of the chemokine MIP-1beta/CCL4 affects receptor specificity but not anti-HIV-1 activity."
J. Biol. Chem. 277:32348-32352(2002) [PubMed] [Europe PMC] [Abstract]

"Macrophage inflammatory protein-1."
Cytokine Growth Factor Rev. 13:455-481(2002) [PubMed] [Europe PMC] [Abstract]

"High-resolution solution structure of the beta chemokine hMIP-1 beta by multidimensional NMR."
Science 263:1762-1767(1994) [PubMed] [Europe PMC] [Abstract]