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Macrophage Inflammatory Protein 3 Alpha (MIP3a)

CCL20; CKb4; LARC; MIP3-A; SCYA20; ST38; Small Inducible Cytokine Subfamily A(Cys-Cys)Member 20; Beta-Chemokine Exodus-1; Liver And Activation-Regulated Chemokine

Chemokine (C-C motif) ligand 20 is a small cytokine belonging to the CC chemokine family. It is strongly chemotactic for lymphocytes and weakly attracts neutrophils.CCL20 is implicated in the formation and function of mucosal lymphoid tissues via chemoattraction of lymphocytes and dendritic cells towards the epithelial cells surrounding these tissues.

CCL20 elicits its effects on its target cells by binding and activating the chemokine receptor CCR6.CCL20 can be induced by microbial factors such as lipopolysaccharide, and inflammatory cytokines such as tumor necrosis factor and interferon-γ, and down-regulated by IL-10. CCL20 is expressed in several tissues with highest expression observed in peripheral blood lymphocytes, lymph nodes, liver, appendix, and fetal lung and lower levels in thymus, testis, prostate and gut.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW615Hu01 Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW615Hu01 Monoclonal Antibody to Macrophage Inflammatory Protein 3 Alpha (MIP3a) WB; IHC; ICC; IP.
PAW615Hu01 Polyclonal Antibody to Macrophage Inflammatory Protein 3 Alpha (MIP3a) WB; IHC; ICC; IF.
Assay Kits CLW615Hu01 CLIA Kit for Macrophage Inflammatory Protein 3 Alpha (MIP3a) CLIA assay for Antigen Detection
ELW615Hu01 ELISA Kit for Macrophage Inflammatory Protein 3 Alpha (MIP3a) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW615Mu01 Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW615Mu01 Monoclonal Antibody to Macrophage Inflammatory Protein 3 Alpha (MIP3a) WB; IHC; ICC; IP.
PAW615Mu01 Polyclonal Antibody to Macrophage Inflammatory Protein 3 Alpha (MIP3a) WB; IHC; ICC; IF.
Assay Kits CLW615Mu01 CLIA Kit for Macrophage Inflammatory Protein 3 Alpha (MIP3a) CLIA assay for Antigen Detection
ELW615Mu01 ELISA Kit for Macrophage Inflammatory Protein 3 Alpha (MIP3a) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW615Ra01 Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW615Ra01 Monoclonal Antibody to Macrophage Inflammatory Protein 3 Alpha (MIP3a) WB; IHC; ICC; IP.
PAW615Ra01 Polyclonal Antibody to Macrophage Inflammatory Protein 3 Alpha (MIP3a) WB; IHC; ICC; IF.
Assay Kits CLW615Ra01 CLIA Kit for Macrophage Inflammatory Protein 3 Alpha (MIP3a) CLIA assay for Antigen Detection
ELW615Ra01 ELISA Kit for Macrophage Inflammatory Protein 3 Alpha (MIP3a) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW615Ca01 Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW615Ca01 Monoclonal Antibody to Macrophage Inflammatory Protein 3 Alpha (MIP3a) WB; IHC; ICC; IP.
PAW615Ca01 Polyclonal Antibody to Macrophage Inflammatory Protein 3 Alpha (MIP3a) WB; IHC; ICC; IF.
Assay Kits CLW615Ca01 CLIA Kit for Macrophage Inflammatory Protein 3 Alpha (MIP3a) CLIA assay for Antigen Detection
ELW615Ca01 ELISA Kit for Macrophage Inflammatory Protein 3 Alpha (MIP3a) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW615Po01 Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW615Po01 Monoclonal Antibody to Macrophage Inflammatory Protein 3 Alpha (MIP3a) WB; IHC; ICC; IP.
PAW615Po01 Polyclonal Antibody to Macrophage Inflammatory Protein 3 Alpha (MIP3a) WB; IHC; ICC; IF.
Assay Kits CLW615Po01 CLIA Kit for Macrophage Inflammatory Protein 3 Alpha (MIP3a) CLIA assay for Antigen Detection
ELW615Po01 ELISA Kit for Macrophage Inflammatory Protein 3 Alpha (MIP3a) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW615Bo01 Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW615Bo01 Monoclonal Antibody to Macrophage Inflammatory Protein 3 Alpha (MIP3a) WB; IHC; ICC; IP.
PAW615Bo01 Polyclonal Antibody to Macrophage Inflammatory Protein 3 Alpha (MIP3a) WB; IHC; ICC; IF.
Assay Kits CLW615Bo01 CLIA Kit for Macrophage Inflammatory Protein 3 Alpha (MIP3a) CLIA assay for Antigen Detection
ELW615Bo01 ELISA Kit for Macrophage Inflammatory Protein 3 Alpha (MIP3a) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW615Rb01 Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW615Rb01 Monoclonal Antibody to Macrophage Inflammatory Protein 3 Alpha (MIP3a) WB; IHC; ICC; IP.
PAW615Rb01 Polyclonal Antibody to Macrophage Inflammatory Protein 3 Alpha (MIP3a) WB; IHC; ICC; IF.
Assay Kits CLW615Rb01 CLIA Kit for Macrophage Inflammatory Protein 3 Alpha (MIP3a) CLIA assay for Antigen Detection
ELW615Rb01 ELISA Kit for Macrophage Inflammatory Protein 3 Alpha (MIP3a) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW615Mo01 Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW615Mo01 Monoclonal Antibody to Macrophage Inflammatory Protein 3 Alpha (MIP3a) WB; IHC; ICC; IP.
PAW615Mo01 Polyclonal Antibody to Macrophage Inflammatory Protein 3 Alpha (MIP3a) WB; IHC; ICC; IF.
Assay Kits CLW615Mo01 CLIA Kit for Macrophage Inflammatory Protein 3 Alpha (MIP3a) CLIA assay for Antigen Detection
ELW615Mo01 ELISA Kit for Macrophage Inflammatory Protein 3 Alpha (MIP3a) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3alpha and MIP-3beta."
J. Immunol. 158:1033-1036(1997) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning of a novel human CC chemokine liver and activation-regulated chemokine (LARC) expressed in liver. Chemotactic activity for lymphocytes and gene localization on chromosome 2."
J. Biol. Chem. 272:5846-5853(1997) [PubMed] [Europe PMC] [Abstract]

"Cloning and characterization of Exodus, a novel beta-chemokine."
Blood 89:3315-3322(1997) [PubMed] [Europe PMC] [Abstract]

"Genomic organization of the CC chemokine mip-3alpha/CCL20/larc/ exodus/SCYA20, showing gene structure, splice variants, and chromosome localization."
Genomics 73:28-37(2001) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Regulated production and molecular diversity of human liver and activation-regulated chemokine/macrophage inflammatory protein-3 alpha from normal and transformed cells."
J. Immunol. 165:4470-4477(2000) [PubMed] [Europe PMC] [Abstract]

"The structure of human macrophage inflammatory protein-3alpha /CCL20. Linking antimicrobial and CC chemokine receptor-6-binding activities with human beta-defensins."
J. Biol. Chem. 277:37647-37654(2002) [PubMed] [Europe PMC] [Abstract]