Matrix Metalloproteinase 13 (MMP13)
CLG3; Collagenase 3
MMP-13 has been proposed to participate in aggrecan degradation associated with osteoarthritis and cleavage of type II collagen in osteoarthritic cartilage explants and in tumor progression and metastasis . In addition, it can cleave type I, III, IV, IX, X and XIV collagens and fibronectin. MMP-13 is likely to play a crucial role in the modulation of extracellular matrix degradation and cell-matrix interactions .MMP-13 is expressed by several metastatic tumors including breast carcinomas, chondrosarcomas, head and neck carcinomas, and in degenerative bone diseases including rheumatoid arthritis. Wild type and mutant p53, a tumor suppressor gene, differentially regulate MMP-13 gene expression . Members of the activator protein-1 and core-binding factor families increase MMP-13 promoter activity in normal, differentiating osteoblasts .
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | W611Hu01 | Recombinant Matrix Metalloproteinase 13 (MMP13) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Matrix Metalloproteinase 13 (MMP13) | Bioactivity | |
| Antibodies | MW611Hu22 | Monoclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | WB; IHC; ICC; IP. |
| PW611Hu01 | Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | WB; IHC; ICC; IF. | |
| LW611Hu71 | Biotin Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEW611Hu | ELISA Kit for Matrix Metalloproteinase 13 (MMP13) | Enzyme-linked immunosorbent assay for Antigen Detection |
| KCW611Hu | CLIA kit for Matrix Metalloproteinase 13 (MMP13) | CLIA assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | W611Mu01 | Recombinant Matrix Metalloproteinase 13 (MMP13) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Matrix Metalloproteinase 13 (MMP13) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | WB; IHC; ICC; IP. |
| PW611Mu01 | Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | WB; IHC; ICC; IF. | |
| LW611Mu71 | Biotin Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEW611Mu | ELISA Kit for Matrix Metalloproteinase 13 (MMP13) | Enzyme-linked immunosorbent assay for Antigen Detection |
| KCW611Mu | CLIA kit for Matrix Metalloproteinase 13 (MMP13) | CLIA assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | W611Ra01 | Recombinant Matrix Metalloproteinase 13 (MMP13) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Matrix Metalloproteinase 13 (MMP13) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | WB; IHC; ICC; IP. |
| PW611Ra01 | Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | WB; IHC; ICC; IF. | |
| LW611Ra71 | Biotin Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEW611Ra | ELISA Kit for Matrix Metalloproteinase 13 (MMP13) | Enzyme-linked immunosorbent assay for Antigen Detection |
| KCW611Ra | CLIA kit for Matrix Metalloproteinase 13 (MMP13) | CLIA assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | W611Ca01 | Recombinant Matrix Metalloproteinase 13 (MMP13) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Matrix Metalloproteinase 13 (MMP13) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | WB; IHC; ICC; IP. |
| PW611Ca01 | Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Matrix Metalloproteinase 13 (MMP13) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Matrix Metalloproteinase 13 (MMP13) | CLIA assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | W611Po01 | Recombinant Matrix Metalloproteinase 13 (MMP13) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Matrix Metalloproteinase 13 (MMP13) | Bioactivity | |
| Antibodies | MW611Po21 | Monoclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | WB; IHC; ICC; IP. |
| PW611Po01 | Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEW611Po | ELISA Kit for Matrix Metalloproteinase 13 (MMP13) | Enzyme-linked immunosorbent assay for Antigen Detection |
| KCW611Po | CLIA kit for Matrix Metalloproteinase 13 (MMP13) | CLIA assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | W611Bo01 | Recombinant Matrix Metalloproteinase 13 (MMP13) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Matrix Metalloproteinase 13 (MMP13) | Bioactivity | |
| Antibodies | MW611Bo21 | Monoclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | WB; IHC; ICC; IP. |
| PW611Bo01 | Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEW611Bo | ELISA Kit for Matrix Metalloproteinase 13 (MMP13) | Enzyme-linked immunosorbent assay for Antigen Detection |
| KCW611Bo | CLIA kit for Matrix Metalloproteinase 13 (MMP13) | CLIA assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Matrix Metalloproteinase 13 (MMP13) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Matrix Metalloproteinase 13 (MMP13) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Matrix Metalloproteinase 13 (MMP13) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Matrix Metalloproteinase 13 (MMP13) | CLIA assay for Antigen Detection |
Organism species: Chicken (Gallus)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | W611Ga01 | Recombinant Matrix Metalloproteinase 13 (MMP13) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Matrix Metalloproteinase 13 (MMP13) | Bioactivity | |
| Antibodies | MW611Ga21 | Monoclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | WB; IHC; ICC; IP. |
| PW611Ga01 | Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEW611Ga | ELISA Kit for Matrix Metalloproteinase 13 (MMP13) | Enzyme-linked immunosorbent assay for Antigen Detection |
| KCW611Ga | CLIA kit for Matrix Metalloproteinase 13 (MMP13) | CLIA assay for Antigen Detection |
Organism species: Ovis aries; Ovine (Sheep)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Matrix Metalloproteinase 13 (MMP13) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Matrix Metalloproteinase 13 (MMP13) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Matrix Metalloproteinase 13 (MMP13) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Matrix Metalloproteinase 13 (MMP13) | CLIA assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | W611Rb01 | Recombinant Matrix Metalloproteinase 13 (MMP13) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Matrix Metalloproteinase 13 (MMP13) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | WB; IHC; ICC; IP. |
| PW611Rb51 | Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | WB; IHC; ICC; IF. | |
| LW611Rb71 | Biotin Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | Flow Cytometry | |
| LW611Rb81 | FITC Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEW611Rb | ELISA Kit for Matrix Metalloproteinase 13 (MMP13) | Enzyme-linked immunosorbent assay for Antigen Detection |
| KCW611Rb | CLIA kit for Matrix Metalloproteinase 13 (MMP13) | CLIA assay for Antigen Detection |
Organism species: Cavia (Guinea pig )
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Matrix Metalloproteinase 13 (MMP13) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Matrix Metalloproteinase 13 (MMP13) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Matrix Metalloproteinase 13 (MMP13) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Matrix Metalloproteinase 13 (MMP13) | CLIA assay for Antigen Detection |
Organism species: Equus caballus; Equine (Horse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | W611Eq01 | Recombinant Matrix Metalloproteinase 13 (MMP13) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Matrix Metalloproteinase 13 (MMP13) | Bioactivity | |
| Antibodies | MW611Eq21 | Monoclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | WB; IHC; ICC; IP. |
| PW611Eq01 | Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEW611Eq | ELISA Kit for Matrix Metalloproteinase 13 (MMP13) | Enzyme-linked immunosorbent assay for Antigen Detection |
| KCW611Eq | CLIA kit for Matrix Metalloproteinase 13 (MMP13) | CLIA assay for Antigen Detection |
Organism species: Capra hircus; Caprine (Goat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | W611Cp01 | Recombinant Matrix Metalloproteinase 13 (MMP13) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Matrix Metalloproteinase 13 (MMP13) | Bioactivity | |
| Antibodies | MW611Cp21 | Monoclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | WB; IHC; ICC; IP. |
| PW611Cp01 | Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEW611Cp | ELISA Kit for Matrix Metalloproteinase 13 (MMP13) | Enzyme-linked immunosorbent assay for Antigen Detection |
| KCW611Cp | CLIA kit for Matrix Metalloproteinase 13 (MMP13) | CLIA assay for Antigen Detection |
Organism species: Pan-species (General)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Matrix Metalloproteinase 13 (MMP13) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Matrix Metalloproteinase 13 (MMP13) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Matrix Metalloproteinase 13 (MMP13) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Matrix Metalloproteinase 13 (MMP13) | CLIA assay for Antigen Detection |
Reference
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"A matrix metalloproteinase gene expressed in human T lymphocytes is identical with collagenase 3 from breast carcinomas."
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"Collagenase-3 (MMP-13) is expressed by hypertrophic chondrocytes, periosteal cells, and osteoblasts during human fetal bone development."
Dev. Dyn. 208:387-397(1997) [PubMed] [Europe PMC] [Abstract]
"The role of the C-terminal domain of human collagenase-3 (MMP-13) in the activation of procollagenase-3, substrate specificity, and tissue inhibitor of metalloproteinase interaction."
J. Biol. Chem. 272:7608-7616(1997) [PubMed] [Europe PMC] [Abstract]
"A secreted tyrosine kinase acts in the extracellular environment."
Cell 158:1033-1044(2014) [PubMed] [Europe PMC] [Abstract]
"The helping hand of collagenase-3 (MMP-13): 2.7 A crystal structure of its C-terminal haemopexin-like domain."
J. Mol. Biol. 264:556-566(1996) [PubMed] [Europe PMC] [Abstract]
"Crystal structures of MMP-1 and -13 reveal the structural basis for selectivity of collagenase inhibitors."
Nat. Struct. Biol. 6:217-221(1999) [PubMed] [Europe PMC] [Abstract]
"Solution structure of the catalytic domain of human collagenase-3 (MMP-13) complexed to a potent non-peptidic sulfonamide inhibitor: binding comparison with stromelysin-1 and collagenase-1."
J. Mol. Biol. 301:513-524(2000) [PubMed] [Europe PMC] [Abstract]
"High-resolution solution structure of the catalytic fragment of human collagenase-3 (MMP-13) complexed with a hydroxamic acid inhibitor."
J. Mol. Biol. 302:671-689(2000) [PubMed] [Europe PMC] [Abstract]
"Potent pyrimidinetrione-based inhibitors of MMP-13 with enhanced selectivity over MMP-14."
Bioorg. Med. Chem. Lett. 15:1807-1810(2005) [PubMed] [Europe PMC] [Abstract]
"Structural basis for the highly selective inhibition of MMP-13."
Chem. Biol. 12:181-189(2005) [PubMed] [Europe PMC] [Abstract]
"Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects."
J. Biol. Chem. 282:27781-27791(2007) [PubMed] [Europe PMC] [Abstract]
"Flexibility and variability of TIMP binding: X-ray structure of the complex between collagenase-3/MMP-13 and TIMP-2."
J. Mol. Biol. 366:1222-1231(2007) [PubMed] [Europe PMC] [Abstract]
"Discovery of potent, selective, and orally active carboxylic acid based inhibitors of matrix metalloproteinase-13."
J. Med. Chem. 52:3523-3538(2009) [PubMed] [Europe PMC] [Abstract]
"Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis."
Bioorg. Med. Chem. Lett. 20:576-580(2010) [PubMed] [Europe PMC] [Abstract]
"Orally active MMP-1 sparing alpha-tetrahydropyranyl and alpha-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease."
J. Med. Chem. 53:6653-6680(2010) [PubMed] [Europe PMC] [Abstract]
"Simple pseudo-dipeptides with a P2' glutamate: a novel inhibitor family of matrix metalloproteases and other metzincins."
J. Biol. Chem. 287:26647-26656(2012) [PubMed] [Europe PMC] [Abstract]
"Hydantoin based inhibitors of MMP13--discovery of AZD6605."
Bioorg. Med. Chem. Lett. 23:4705-4712(2013) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of full-length human collagenase 3 (MMP-13) with peptides in the active site defines exosites in the catalytic domain."
FASEB J. 27:4395-4405(2013) [PubMed] [Europe PMC] [Abstract]
"MMP13 mutation causes spondyloepimetaphyseal dysplasia, Missouri type (SEMD(MO)."
J. Clin. Invest. 115:2832-2842(2005) [PubMed] [Europe PMC] [Abstract]
"Mutations in MMP9 and MMP13 determine the mode of inheritance and the clinical spectrum of metaphyseal anadysplasia."
Am. J. Hum. Genet. 85:168-178(2009) [PubMed] [Europe PMC] [Abstract]