Neurotrophin 3 (NT3)

NTF3; HDNF; NGF2; Nerve Growth Factor 2; Neurotrophic Factor

SPN	W604
HGNC	8023
MGI	97380
PubMed	15893630
RGD	619728
UniProt	P20783
Wiki	Neurotrophin3

Neurotrophin-3,or NT-3 is a protein that is encoded by the NTF3 gene, NT-3 is a neurotrophic factor, in the NGF (Nerve Growth Factor)-family of neurotrophins. It is a protein growth factor which has activity on certain neurons of the peripheral and central nervous system; it helps to support the survival and differentiation of existing neurons, and encourages the growth and differentiation of new neurons and synapses.

NT-3 was the third neurotrophic factor to be characterized, after nerve growth factor (NGF) and BDNF (Brain Derived Neurotrophic). NT-3 is unique in the number of neurons it can potentially stimulate, given its ability to activate two of the receptor tyrosine kinase neurotrophin receptors (TrkC and TrkB).

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	W604Hu01	Recombinant Neurotrophin 3 (NT3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Neurotrophin 3 (NT3)	Bioactivity
Antibodies	MW604Hu22	Monoclonal Antibody to Neurotrophin 3 (NT3)	WB; IHC; ICC; IP.
	PW604Hu01	Polyclonal Antibody to Neurotrophin 3 (NT3)	WB; IHC; ICC; IF.
	LW604Hu71	Biotin Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	Flow Cytometry;ICC/IF
Assay Kits	KEW604Hu	ELISA Kit for Neurotrophin 3 (NT3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	KCW604Hu	CLIA kit for Neurotrophin 3 (NT3)	CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	W604Mu01	Recombinant Neurotrophin 3 (NT3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Neurotrophin 3 (NT3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Neurotrophin 3 (NT3)	WB; IHC; ICC; IP.
	PW604Mu01	Polyclonal Antibody to Neurotrophin 3 (NT3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	Flow Cytometry;ICC/IF
Assay Kits	KEW604Mu	ELISA Kit for Neurotrophin 3 (NT3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Neurotrophin 3 (NT3)	CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	W604Ra01	Recombinant Neurotrophin 3 (NT3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Neurotrophin 3 (NT3)	Bioactivity
Antibodies	MW604Ra21	Monoclonal Antibody to Neurotrophin 3 (NT3)	WB; IHC; ICC; IP.
	PW604Ra01	Polyclonal Antibody to Neurotrophin 3 (NT3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	Flow Cytometry;ICC/IF
Assay Kits	KEW604Ra	ELISA Kit for Neurotrophin 3 (NT3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Neurotrophin 3 (NT3)	CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Neurotrophin 3 (NT3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Neurotrophin 3 (NT3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Neurotrophin 3 (NT3)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Neurotrophin 3 (NT3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Neurotrophin 3 (NT3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Neurotrophin 3 (NT3)	CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	W604Po01	Recombinant Neurotrophin 3 (NT3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Neurotrophin 3 (NT3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Neurotrophin 3 (NT3)	WB; IHC; ICC; IP.
	PW604Po01	Polyclonal Antibody to Neurotrophin 3 (NT3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Neurotrophin 3 (NT3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Neurotrophin 3 (NT3)	CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	W604Bo01	Recombinant Neurotrophin 3 (NT3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Neurotrophin 3 (NT3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Neurotrophin 3 (NT3)	WB; IHC; ICC; IP.
	PW604Bo01	Polyclonal Antibody to Neurotrophin 3 (NT3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Neurotrophin 3 (NT3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Neurotrophin 3 (NT3)	CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Neurotrophin 3 (NT3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Neurotrophin 3 (NT3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Neurotrophin 3 (NT3)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Neurotrophin 3 (NT3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Neurotrophin 3 (NT3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Neurotrophin 3 (NT3)	CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	W604Ga01	Recombinant Neurotrophin 3 (NT3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Neurotrophin 3 (NT3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Neurotrophin 3 (NT3)	WB; IHC; ICC; IP.
	PW604Ga01	Polyclonal Antibody to Neurotrophin 3 (NT3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Neurotrophin 3 (NT3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Neurotrophin 3 (NT3)	CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Neurotrophin 3 (NT3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Neurotrophin 3 (NT3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Neurotrophin 3 (NT3)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Neurotrophin 3 (NT3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Neurotrophin 3 (NT3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Neurotrophin 3 (NT3)	CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Neurotrophin 3 (NT3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Neurotrophin 3 (NT3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Neurotrophin 3 (NT3)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Neurotrophin 3 (NT3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Neurotrophin 3 (NT3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Neurotrophin 3 (NT3)	CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Neurotrophin 3 (NT3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Neurotrophin 3 (NT3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Neurotrophin 3 (NT3)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Neurotrophin 3 (NT3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Neurotrophin 3 (NT3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Neurotrophin 3 (NT3)	CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Neurotrophin 3 (NT3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Neurotrophin 3 (NT3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Neurotrophin 3 (NT3)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Neurotrophin 3 (NT3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Neurotrophin 3 (NT3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Neurotrophin 3 (NT3)	CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Neurotrophin 3 (NT3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Neurotrophin 3 (NT3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Neurotrophin 3 (NT3)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Neurotrophin 3 (NT3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Neurotrophin 3 (NT3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Neurotrophin 3 (NT3)	CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Neurotrophin 3 (NT3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Neurotrophin 3 (NT3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Neurotrophin 3 (NT3)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Neurotrophin 3 (NT3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Neurotrophin 3 (NT3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Neurotrophin 3 (NT3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Neurotrophin 3 (NT3)	CLIA assay for Antigen Detection

Reference

"Cloning and expression of a cDNA encoding a novel human neurotrophic factor."
FEBS Lett. 266:187-191(1990) [PubMed] [Europe PMC] [Abstract]

"Primary structure and biological activity of a novel human neurotrophic factor."
Neuron 4:767-773(1990) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning of a human gene that is a member of the nerve growth factor family."
Proc. Natl. Acad. Sci. U.S.A. 87:8060-8064(1990) [PubMed] [Europe PMC] [Abstract]

"Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations."
Genomics 10:558-568(1991) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary."
Neuron 6:845-858(1991) [PubMed] [Europe PMC] [Abstract]

"Structure of the brain-derived neurotrophic factor/neurotrophin 3 heterodimer."
Biochemistry 34:4139-4146(1995) [PubMed] [Europe PMC] [Abstract]

"Association of neurotrophin-3 gene variant with severe forms of schizophrenia."
Biochem. Biophys. Res. Commun. 209:513-518(1995) [PubMed] [Europe PMC] [Abstract]

"Failure to find associations of the CA repeat polymorphism in the first intron and the Gly-63/Glu-63 polymorphism of the neurotrophin-3 gene with schizophrenia."
Psychiatr. Genet. 6:13-15(1996) [PubMed] [Europe PMC] [Abstract]