Neurotrophin 4 (NT4)

NT5; NTF4; NT-4/5; Neurotrophic Factor 4; Neurotrophin-5

SPN	W603
HGNC	8024
MGI	97381
PubMed	10631974
RGD	3212
UniProt	P34130
Wiki	Neurotrophin4

Neurotrophin-4 (NT-4) like BDNF, is a neurotrophic factor that signals predominantly through the TrkB receptor tyrosine kinase. It is also known as NT4, NT5, NTF4, and NT-4/5. Differentiation, survival, and function of neurons in vertebrates are controlled by multiple, target-derived neurotrophic factors. The best characterized mammalian neurotrophic factors are 4 structurally related 13- to 14-kD basic proteins known as neurotrophinsBerkemeier et al. (1992) identified a cluster of genes on human chromosome 19 that includes neurotrophin-5 (NT5) and 3 pseudogenes, designated NTF6A, NTF6B, and NTF6G. The NTF5 and NTF6 gene loci were mapped to chromosome 19 by Southern analysis of somatic cell hybrid panels. In the mouse, the Ntf5 gene was assigned to chromosome 7.

Reference

"Neurotrophin-5: a novel neurotrophic factor that activates trk and trkB."
Neuron 7:857-866(1991) [PubMed] [Europe PMC] [Abstract]

"Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity."
Proc. Natl. Acad. Sci. U.S.A. 89:3060-3064(1992) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The structures of the neurotrophin 4 homodimer and the brain-derived neurotrophic factor/neurotrophin 4 heterodimer reveal a common Trk-binding site."
Protein Sci. 8:2589-2597(1999) [PubMed] [Europe PMC] [Abstract]

"Heterozygous NTF4 mutations impairing neurotrophin-4 signaling in patients with primary open-angle glaucoma."
Am. J. Hum. Genet. 85:447-456(2009) [PubMed] [Europe PMC] [Abstract]

"No evidence of association of heterozygous NTF4 mutations in patients with primary open-angle glaucoma."
Am. J. Hum. Genet. 86:498-499(2010) [PubMed] [Europe PMC] [Abstract]