Oncostatin M (OSM)

OS-M

SPN	W600
HGNC	8506
MGI	104749
PubMed	1338575
RGD	1585012
UniProt	P13725
Wiki	Oncostatin_M

Oncostatin M(OSM) is a cytokine originally isolated from medium conditioned by PMA-treated U-937 histiocytic leukemia cells based on its ability to inhibit growth of A375 melanoma cells. The OSM cDNA encodes a 252 amino acid pre-pro-OSM polypeptide with a 25 residue hydrophobic signal peptide and a hydrophilic C-terminal domain that are proteolytically processed to generate the 196 residue mature form of OSM. Although both mature and pro-OSM are equally active in radio-receptor assays, the mature OSM is 5- to 60-fold more active in growth inhibition assays. Thus, proteolytic processing of the pro-OSM peptide may be important in regulating the in vivo activities of OSM.OSM is a pleiotropic cytokine that initiates its biological activities by binding to specific cell surface receptors.

Reference

"Molecular cloning, sequence analysis, and functional expression of a novel growth regulator, oncostatin M."
Mol. Cell. Biol. 9:2847-2853(1989) [PubMed] [Europe PMC] [Abstract]

"A genome annotation-driven approach to cloning the human ORFeome."
Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of human chromosome 22."
Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Oncostatin M: a growth regulator produced by differentiated histiocytic lymphoma cells."
Proc. Natl. Acad. Sci. U.S.A. 83:9739-9743(1986) [PubMed] [Europe PMC] [Abstract]

"Identification of a major growth factor for AIDS-Kaposi's sarcoma cells as oncostatin M."
Science 255:1430-1432(1992) [PubMed] [Europe PMC] [Abstract]

"Cleavage of a hydrophilic C-terminal domain increases growth-inhibitory activity of oncostatin M."
Mol. Cell. Biol. 10:1882-1890(1990) [PubMed] [Europe PMC] [Abstract]

"Disulfide bond assignment and identification of regions required for functional activity of oncostatin M."
J. Biol. Chem. 266:8940-8945(1991) [PubMed] [Europe PMC] [Abstract]

"Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6."
Proc. Natl. Acad. Sci. U.S.A. 88:8641-8645(1991) [PubMed] [Europe PMC] [Abstract]

"Oncostatin M as a potent mitogen for AIDS-Kaposi's sarcoma-derived cells."
Science 255:1432-1434(1992) [PubMed] [Europe PMC] [Abstract]

"Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation."
J. Biol. Chem. 271:32635-32643(1996) [PubMed] [Europe PMC] [Abstract]

"Crystal structure and functional dissection of the cytostatic cytokine oncostatin M."
Structure 8:863-874(2000) [PubMed] [Europe PMC] [Abstract]