Betacellulin (bTC)

Probetacellulin

SPN	W599
HGNC	1121
MGI	99439
PubMed	10940639
RGD	620275
UniProt	P35070
Wiki	Betacellulin

Betacellulin(BTC),has been identified in the conditioned medium of cell lines derived from mouse pancreatic beta cell tumors. Betacellulin is a 32-kilodalton glycoprotein that appears to be processed from a larger transmembrane precursor by proteolytic cleavage. The carboxyl-terminal domain of betacellulin has 50 percent sequence similarity with that of rat transforming growth factor alpha. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.Watanabe et al. purified soluble forms of human BTC to homogeneity from the conditioned medium of mouse A9 cells transfected with the human BTC precursor cDNA. Three types of soluble BTC, apparently derived from a single gene, were identified and their biologic activities assessed.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	W599Hu01	Recombinant Betacellulin (bTC)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Betacellulin (bTC)	Bioactivity
Antibodies	MW599Hu22	Monoclonal Antibody to Betacellulin (bTC)	WB; IHC; ICC; IP.
	PW599Hu01	Polyclonal Antibody to Betacellulin (bTC)	WB; IHC; ICC; IF.
	LW599Hu71	Biotin Linked-Polyclonal Antibody to Betacellulin (bTC)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Betacellulin (bTC)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Betacellulin (bTC)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Betacellulin (bTC)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Betacellulin (bTC)	Flow Cytometry;ICC/IF
Assay Kits	KEW599Hu	ELISA Kit for Betacellulin (bTC)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Betacellulin (bTC)	CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	W599Mu01	Recombinant Betacellulin (bTC)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Betacellulin (bTC)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Betacellulin (bTC)	WB; IHC; ICC; IP.
	PW599Mu01	Polyclonal Antibody to Betacellulin (bTC)	WB; IHC; ICC; IF.
	LW599Mu71	Biotin Linked-Polyclonal Antibody to Betacellulin (bTC)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Betacellulin (bTC)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Betacellulin (bTC)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Betacellulin (bTC)	Flow Cytometry
	LW599Mu81	FITC Linked-Polyclonal Antibody to Betacellulin (bTC)	Flow Cytometry;ICC/IF
Assay Kits	KEW599Mu	ELISA Kit for Betacellulin (bTC)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Betacellulin (bTC)	CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	W599Ra01	Recombinant Betacellulin (bTC)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Betacellulin (bTC)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Betacellulin (bTC)	WB; IHC; ICC; IP.
	PW599Ra01	Polyclonal Antibody to Betacellulin (bTC)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Betacellulin (bTC)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Betacellulin (bTC)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Betacellulin (bTC)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Betacellulin (bTC)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Betacellulin (bTC)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Betacellulin (bTC)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Betacellulin (bTC)	CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Betacellulin (bTC)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Betacellulin (bTC)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Betacellulin (bTC)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Betacellulin (bTC)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Betacellulin (bTC)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Betacellulin (bTC)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Betacellulin (bTC)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Betacellulin (bTC)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Betacellulin (bTC)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Betacellulin (bTC)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Betacellulin (bTC)	CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Betacellulin (bTC)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Betacellulin (bTC)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Betacellulin (bTC)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Betacellulin (bTC)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Betacellulin (bTC)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Betacellulin (bTC)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Betacellulin (bTC)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Betacellulin (bTC)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Betacellulin (bTC)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Betacellulin (bTC)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Betacellulin (bTC)	CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	W599Bo01	Recombinant Betacellulin (bTC)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Betacellulin (bTC)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Betacellulin (bTC)	WB; IHC; ICC; IP.
	PW599Bo01	Polyclonal Antibody to Betacellulin (bTC)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Betacellulin (bTC)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Betacellulin (bTC)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Betacellulin (bTC)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Betacellulin (bTC)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Betacellulin (bTC)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Betacellulin (bTC)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Betacellulin (bTC)	CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Betacellulin (bTC)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Betacellulin (bTC)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Betacellulin (bTC)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Betacellulin (bTC)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Betacellulin (bTC)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Betacellulin (bTC)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Betacellulin (bTC)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Betacellulin (bTC)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Betacellulin (bTC)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Betacellulin (bTC)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Betacellulin (bTC)	CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	W599Ga01	Recombinant Betacellulin (bTC)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Betacellulin (bTC)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Betacellulin (bTC)	WB; IHC; ICC; IP.
	PW599Ga01	Polyclonal Antibody to Betacellulin (bTC)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Betacellulin (bTC)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Betacellulin (bTC)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Betacellulin (bTC)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Betacellulin (bTC)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Betacellulin (bTC)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Betacellulin (bTC)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Betacellulin (bTC)	CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Betacellulin (bTC)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Betacellulin (bTC)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Betacellulin (bTC)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Betacellulin (bTC)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Betacellulin (bTC)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Betacellulin (bTC)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Betacellulin (bTC)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Betacellulin (bTC)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Betacellulin (bTC)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Betacellulin (bTC)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Betacellulin (bTC)	CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Betacellulin (bTC)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Betacellulin (bTC)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Betacellulin (bTC)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Betacellulin (bTC)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Betacellulin (bTC)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Betacellulin (bTC)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Betacellulin (bTC)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Betacellulin (bTC)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Betacellulin (bTC)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Betacellulin (bTC)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Betacellulin (bTC)	CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Betacellulin (bTC)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Betacellulin (bTC)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Betacellulin (bTC)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Betacellulin (bTC)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Betacellulin (bTC)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Betacellulin (bTC)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Betacellulin (bTC)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Betacellulin (bTC)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Betacellulin (bTC)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Betacellulin (bTC)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Betacellulin (bTC)	CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Betacellulin (bTC)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Betacellulin (bTC)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Betacellulin (bTC)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Betacellulin (bTC)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Betacellulin (bTC)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Betacellulin (bTC)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Betacellulin (bTC)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Betacellulin (bTC)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Betacellulin (bTC)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Betacellulin (bTC)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Betacellulin (bTC)	CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Betacellulin (bTC)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Betacellulin (bTC)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Betacellulin (bTC)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Betacellulin (bTC)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Betacellulin (bTC)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Betacellulin (bTC)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Betacellulin (bTC)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Betacellulin (bTC)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Betacellulin (bTC)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Betacellulin (bTC)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Betacellulin (bTC)	CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Betacellulin (bTC)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Betacellulin (bTC)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Betacellulin (bTC)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Betacellulin (bTC)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Betacellulin (bTC)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Betacellulin (bTC)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Betacellulin (bTC)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Betacellulin (bTC)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Betacellulin (bTC)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Betacellulin (bTC)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Betacellulin (bTC)	CLIA assay for Antigen Detection

Reference

"Cloning and expression of cDNA encoding human betacellulin, a new member of the EGF family."
Biochem. Biophys. Res. Commun. 190:1173-1179(1993) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Recombinant human betacellulin. Molecular structure, biological activities, and receptor interaction."
J. Biol. Chem. 269:9966-9973(1994) [PubMed] [Europe PMC] [Abstract]

"Human betacellulin, a member of the EGF family dominantly expressed in pancreas and small intestine, is fully active in a monomeric form."
Growth Factors 13:181-191(1996) [PubMed] [Europe PMC] [Abstract]

"Betacellulin activates the epidermal growth factor receptor and erbB-4, and induces cellular response patterns distinct from those stimulated by epidermal growth factor or neuregulin-beta."
Oncogene 12:345-353(1996) [PubMed] [Europe PMC] [Abstract]

"Ligand discrimination in signaling through an ErbB4 receptor homodimer."
J. Biol. Chem. 275:19803-19807(2000) [PubMed] [Europe PMC] [Abstract]

"Solution structure of betacellulin, a new member of EGF-family ligands."
Biochem. Biophys. Res. Commun. 294:1040-1046(2002) [PubMed] [Europe PMC] [Abstract]