Ribonuclease T2 (RNASET2)

Rnase-T2; RNASE6PL; RNASE6-PL; Ribonuclease 6

SPN	W598
HGNC	21686
MGI	1915445
PubMed	17109444
RGD	1309918
UniProt	O00584
Wiki	RNASET2

• RNASET2 belongs to the RNase T2 family (EC 3.1.27.1) of proteins that are present in all phyla and primarily function in the extracellular milieu. In some microorganisms and plants, T2 RNases mediate phosphate uptake by digesting extracellular RNAs. In other species, they provide host protection against pathogens or trigger cellular senescence. Human RNASET2 appears to suppress tumorigenicity. By searching for coding sequences in a region of chromosome 6 that is frequently rearranged in malignancies, followed by screening a pooled tissue cDNA library, Trubia et al. (1997) cloned RNASET2. The deduced 191-amino acid protein contains 2 highly conserved pentameric catalytic motifs. Northern blot analysis detected a 1.2-kb transcript in all tissues examined.

Reference

"Mammalian Rh/T2/S-glycoprotein ribonuclease family genes: cloning of a human member located in a region of chromosome 6 (6q27) frequently deleted in human malignancies."
Genomics 42:342-344(1997) [PubMed] [Europe PMC] [Abstract]

"Physical and transcript map of the region between D6S264 and D6S149 on chromosome 6q27, the minimal region of allele loss in sporadic epithelial ovarian cancer."
Oncogene 21:387-399(2002) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 6."
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Tumor and metastasis suppression by the human RNASET2 gene."
Int. J. Oncol. 26:1159-1168(2005) [PubMed] [Europe PMC] [Abstract]

"Characterization of RNASET2, the first human member of the Rh/T2/S family of glycoproteins."
Arch. Biochem. Biophys. 449:17-26(2006) [PubMed] [Europe PMC] [Abstract]

"RNASET2-deficient cystic leukoencephalopathy resembles congenital cytomegalovirus brain infection."
Nat. Genet. 41:773-775(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"rnaset2 mutant zebrafish model familial cystic leukoencephalopathy and reveal a role for RNase T2 in degrading ribosomal RNA."
Proc. Natl. Acad. Sci. U.S.A. 108:1099-1103(2011) [PubMed] [Europe PMC] [Abstract]

"Structure and activity of the only human RNase T2."
Nucleic Acids Res. 40:8733-8742(2012) [PubMed] [Europe PMC] [Abstract]