Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES)
CCL5; SCYA5; SISd; EoCP; Chemokine C-C-Motif Ligand 5; Eosinophil Chemotactic Cytokine; T-cell Specific Protein p288; Small Inducible Cytokine Subfamily A(Cys-Cys)Member 5
Regulated on activation in normal T cell expressed and secreted(RANTES) was identified in 1988, as a result of a subtractive hybridization screen for mRNA expressed by T cells, but not by B cells. In addition to T cells, RANTES is also produced by epithelial cells, monocytes, fibroblasts, and mesanglial cells. Platelets and eosinophils release RANTES from intracellular storage granules upon activation. Several high affinity receptors for RANTES have been described, including CCR1, CCR3, CCR5, and cytomegalovirus receptor US28. RANTES also binds to the erythrocyte Duffy antigen receptor (DARC) with low affinity. RANTES regulates the trafficking of cells expressing these receptors, including T cells, eosinophils, basophils, monocytes, macrophages, microglia, NK cells, dendritic cells, mast cells, and neurons.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW596Hu01 | Recombinant Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW596Hu01 | Monoclonal Antibody to Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) | WB; IHC; ICC; IP. |
| PAW596Hu01 | Polyclonal Antibody to Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW596Hu01 | CLIA Kit for Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) | CLIA assay for Antigen Detection |
| ELW596Hu01 | ELISA Kit for Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW596Mu01 | Recombinant Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW596Mu01 | Monoclonal Antibody to Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) | WB; IHC; ICC; IP. |
| PAW596Mu01 | Polyclonal Antibody to Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW596Mu01 | CLIA Kit for Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) | CLIA assay for Antigen Detection |
| ELW596Mu01 | ELISA Kit for Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW596Ra01 | Recombinant Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW596Ra01 | Monoclonal Antibody to Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) | WB; IHC; ICC; IP. |
| PAW596Ra01 | Polyclonal Antibody to Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW596Ra01 | CLIA Kit for Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) | CLIA assay for Antigen Detection |
| ELW596Ra01 | ELISA Kit for Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW596Ca01 | Recombinant Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW596Ca01 | Monoclonal Antibody to Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) | WB; IHC; ICC; IP. |
| PAW596Ca01 | Polyclonal Antibody to Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW596Ca01 | CLIA Kit for Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) | CLIA assay for Antigen Detection |
| ELW596Ca01 | ELISA Kit for Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW596Po01 | Recombinant Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW596Po01 | Monoclonal Antibody to Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) | WB; IHC; ICC; IP. |
| PAW596Po01 | Polyclonal Antibody to Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW596Po01 | CLIA Kit for Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) | CLIA assay for Antigen Detection |
| ELW596Po01 | ELISA Kit for Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW596Bo01 | Recombinant Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW596Bo01 | Monoclonal Antibody to Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) | WB; IHC; ICC; IP. |
| PAW596Bo01 | Polyclonal Antibody to Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW596Bo01 | CLIA Kit for Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) | CLIA assay for Antigen Detection |
| ELW596Bo01 | ELISA Kit for Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW596Rb01 | Recombinant Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW596Rb01 | Monoclonal Antibody to Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) | WB; IHC; ICC; IP. |
| PAW596Rb01 | Polyclonal Antibody to Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW596Rb01 | CLIA Kit for Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) | CLIA assay for Antigen Detection |
| ELW596Rb01 | ELISA Kit for Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW596Mo01 | Recombinant Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW596Mo01 | Monoclonal Antibody to Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) | WB; IHC; ICC; IP. |
| PAW596Mo01 | Polyclonal Antibody to Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW596Mo01 | CLIA Kit for Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) | CLIA assay for Antigen Detection |
| ELW596Mo01 | ELISA Kit for Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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Br. J. Pharmacol. 149:490-497(2006) [PubMed] [Europe PMC] [Abstract]
"The novel chemokine receptor, G-protein-coupled receptor 75, is expressed by islets and is coupled to stimulation of insulin secretion and improved glucose homeostasis."
Diabetologia 56:2467-2476(2013) [PubMed] [Europe PMC] [Abstract]
"Proton NMR assignments and solution conformation of RANTES, a chemokine of the C-C type."
Biochemistry 34:5329-5342(1995) [PubMed] [Europe PMC] [Abstract]
"The three-dimensional solution structure of RANTES."
Biochemistry 34:9307-9314(1995) [PubMed] [Europe PMC] [Abstract]
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Chem. Biol. 6:43-51(1999) [PubMed] [Europe PMC] [Abstract]
"The crystal structure of Met-RANTES: comparison with native RANTES and AOP-RANTES."
Protein Pept. Lett. 7:73-82(2000)