Cluster Of Differentiation 40 Ligand (CD40L)

CD154; TRAP; HIGM1; IGM; IMD3; TBAM; T-BAM; TNFSF5; Gp39; TNF Superfamily Member 5; Hyper-IgM Syndrome; TNF-Related Activation Protein; T-Cell B-Cell Activating Molecule

SPN	W594
HGNC	11935
MGI	88337
PubMed	11229815
RGD	708418
UniProt	P29965
Wiki	CD154

 is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules. It binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. In general, CD40L plays the role of a costimulatory molecule and induces activation in APC in association with T cell receptor stimulation by MHC molecules on the APC. In total CD40L has three binding partners: CD40, α5β1 integrin and αIIbβ3.

CD40L is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper IgM syndrome.

Reference

"Cloning of TRAP, a ligand for CD40 on human T cells."
Eur. J. Immunol. 22:3191-3194(1992) [PubMed] [Europe PMC] [Abstract]

"The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co-stimulatory activity."
EMBO J. 11:4313-4321(1992) [PubMed] [Europe PMC] [Abstract]

"The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome."
Cell 72:291-300(1993) [PubMed] [Europe PMC] [Abstract]

"Recombinant human CD40 ligand stimulates B cell proliferation and immunoglobulin E secretion."
J. Exp. Med. 176:1543-1550(1992) [PubMed] [Europe PMC] [Abstract]

"Human CD40-ligand: molecular cloning, cellular distribution and regulation of expression by factors controlling IgE production."
FEBS Lett. 315:259-266(1993) [PubMed] [Europe PMC] [Abstract]

"Structural organization of the gene for CD40 ligand: molecular analysis for diagnosis of X-linked hyper-IgM syndrome."
Biochim. Biophys. Acta 1260:67-72(1995) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Human native soluble CD40L is a biologically active trimer, processed inside microsomes."
J. Biol. Chem. 271:5965-5967(1996) [PubMed] [Europe PMC] [Abstract]

"Determination of carbohydrate structures N-linked to soluble CD154 and characterization of the interactions of CD40 with CD154 expressed in Pichia pastoris and Chinese hamster ovary cells."
Protein Expr. Purif. 23:301-310(2001) [PubMed] [Europe PMC] [Abstract]

"Release of soluble CD40L from platelets is regulated by glycoprotein IIb/IIIa and actin polymerization."
J. Am. Coll. Cardiol. 43:2319-2325(2004) [PubMed] [Europe PMC] [Abstract]

"2-A crystal structure of an extracellular fragment of human CD40 ligand."
Structure 3:1031-1039(1995) [PubMed] [Europe PMC] [Abstract]

"The role of polar interactions in the molecular recognition of CD40L with its receptor CD40."
Protein Sci. 7:1124-1135(1998) [PubMed] [Europe PMC] [Abstract]

"Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM."
Nature 361:539-541(1993) [PubMed] [Europe PMC] [Abstract]

"CD40 ligand mutations in X-linked immunodeficiency with hyper-IgM."
Nature 361:541-543(1993) [PubMed] [Europe PMC] [Abstract]

"CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome."
Science 259:990-993(1993) [PubMed] [Europe PMC] [Abstract]

"Characterization of nine novel mutations in the CD40 ligand gene in patients with X-linked hyper IgM syndrome of various ancestry."
Am. J. Hum. Genet. 56:898-906(1995) [PubMed] [Europe PMC] [Abstract]

"Signaling through CD40 rescues IgE but not IgG or IgA secretion in X-linked immunodeficiency with hyper-IgM."
J. Clin. Invest. 95:510-514(1995) [PubMed] [Europe PMC] [Abstract]

"Mutation analysis in CD40 ligand deficiency leading to X-linked hypogammaglobulinemia with hyper IgM syndrome."
Hum. Mutat. 8:223-228(1996) [PubMed] [Europe PMC] [Abstract]

"A single strand conformation polymorphism study of CD40 ligand. Efficient mutation analysis and carrier detection for X-linked hyper IgM syndrome."
J. Clin. Invest. 97:196-201(1996) [PubMed] [Europe PMC] [Abstract]

"Mutations of the CD40 ligand gene in 13 Japanese patients with X-linked hyper-IgM syndrome."
Hum. Genet. 99:624-627(1997) [PubMed] [Europe PMC] [Abstract]

"Mutations of the CD40 ligand gene and its effect on CD40 ligand expression in patients with X-linked hyper IgM syndrome."
Blood 92:2421-2434(1998) [PubMed] [Europe PMC] [Abstract]