Stem Cell Factor Receptor (SCFR)
CD117; KIT; C-Kit; PBT; p145 c-Kit; C-Kit Receptor; Tyrosine-Protein Kinase; V-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog; Piebald Trait
Stem cell factor Receptor(SCFR;CD117), also called KIT or C-kit receptor, is a cytokine receptor expressed on the surface of hematopoietic stem cells as well as other cell types. This receptor binds to stem cell factor (a substance that causes certain types of cells to grow). Altered forms of this receptor may be associated with some types of cancer.C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in its encoded gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW592Hu01 | Recombinant Stem Cell Factor Receptor (SCFR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW592Hu01 | Monoclonal Antibody to Stem Cell Factor Receptor (SCFR) | WB; IHC; ICC; IP. |
| PAW592Hu01 | Polyclonal Antibody to Stem Cell Factor Receptor (SCFR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW592Hu01 | CLIA Kit for Stem Cell Factor Receptor (SCFR) | CLIA assay for Antigen Detection |
| ELW592Hu01 | ELISA Kit for Stem Cell Factor Receptor (SCFR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW592Mu01 | Recombinant Stem Cell Factor Receptor (SCFR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW592Mu01 | Monoclonal Antibody to Stem Cell Factor Receptor (SCFR) | WB; IHC; ICC; IP. |
| PAW592Mu01 | Polyclonal Antibody to Stem Cell Factor Receptor (SCFR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW592Mu01 | CLIA Kit for Stem Cell Factor Receptor (SCFR) | CLIA assay for Antigen Detection |
| ELW592Mu01 | ELISA Kit for Stem Cell Factor Receptor (SCFR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW592Ra01 | Recombinant Stem Cell Factor Receptor (SCFR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW592Ra01 | Monoclonal Antibody to Stem Cell Factor Receptor (SCFR) | WB; IHC; ICC; IP. |
| PAW592Ra01 | Polyclonal Antibody to Stem Cell Factor Receptor (SCFR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW592Ra01 | CLIA Kit for Stem Cell Factor Receptor (SCFR) | CLIA assay for Antigen Detection |
| ELW592Ra01 | ELISA Kit for Stem Cell Factor Receptor (SCFR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW592Ca01 | Recombinant Stem Cell Factor Receptor (SCFR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW592Ca01 | Monoclonal Antibody to Stem Cell Factor Receptor (SCFR) | WB; IHC; ICC; IP. |
| PAW592Ca01 | Polyclonal Antibody to Stem Cell Factor Receptor (SCFR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW592Ca01 | CLIA Kit for Stem Cell Factor Receptor (SCFR) | CLIA assay for Antigen Detection |
| ELW592Ca01 | ELISA Kit for Stem Cell Factor Receptor (SCFR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW592Po01 | Recombinant Stem Cell Factor Receptor (SCFR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW592Po01 | Monoclonal Antibody to Stem Cell Factor Receptor (SCFR) | WB; IHC; ICC; IP. |
| PAW592Po01 | Polyclonal Antibody to Stem Cell Factor Receptor (SCFR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW592Po01 | CLIA Kit for Stem Cell Factor Receptor (SCFR) | CLIA assay for Antigen Detection |
| ELW592Po01 | ELISA Kit for Stem Cell Factor Receptor (SCFR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW592Bo01 | Recombinant Stem Cell Factor Receptor (SCFR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW592Bo01 | Monoclonal Antibody to Stem Cell Factor Receptor (SCFR) | WB; IHC; ICC; IP. |
| PAW592Bo01 | Polyclonal Antibody to Stem Cell Factor Receptor (SCFR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW592Bo01 | CLIA Kit for Stem Cell Factor Receptor (SCFR) | CLIA assay for Antigen Detection |
| ELW592Bo01 | ELISA Kit for Stem Cell Factor Receptor (SCFR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW592Rb01 | Recombinant Stem Cell Factor Receptor (SCFR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW592Rb01 | Monoclonal Antibody to Stem Cell Factor Receptor (SCFR) | WB; IHC; ICC; IP. |
| PAW592Rb01 | Polyclonal Antibody to Stem Cell Factor Receptor (SCFR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW592Rb01 | CLIA Kit for Stem Cell Factor Receptor (SCFR) | CLIA assay for Antigen Detection |
| ELW592Rb01 | ELISA Kit for Stem Cell Factor Receptor (SCFR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW592Mo01 | Recombinant Stem Cell Factor Receptor (SCFR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW592Mo01 | Monoclonal Antibody to Stem Cell Factor Receptor (SCFR) | WB; IHC; ICC; IP. |
| PAW592Mo01 | Polyclonal Antibody to Stem Cell Factor Receptor (SCFR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW592Mo01 | CLIA Kit for Stem Cell Factor Receptor (SCFR) | CLIA assay for Antigen Detection |
| ELW592Mo01 | ELISA Kit for Stem Cell Factor Receptor (SCFR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand."
EMBO J. 6:3341-3351(1987) [PubMed] [Europe PMC] [Abstract]
"Organization and nucleotide sequence of the human KIT (mast/stem cell growth factor receptor) proto-oncogene."
Oncogene 7:2207-2217(1992) [PubMed] [Europe PMC] [Abstract]
"Sequence analysis of two genomic regions containing the KIT and the FMS receptor tyrosine kinase genes."
Genomics 39:216-226(1997) [PubMed] [Europe PMC] [Abstract]
"Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis."
Arthritis Res. Ther. 10:R73-R73(2008) [PubMed] [Europe PMC] [Abstract]
"Retinoic acid enhances sensitivity of neuroblastoma cells for imatinib mesylate."
Pediatr. Blood Cancer 55:464-470(2010) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Characterization of the promoter region of the human c-kit proto-oncogene."
Jpn. J. Cancer Res. 84:1136-1144(1993) [PubMed] [Europe PMC] [Abstract]
"Modulation of Kit/stem cell factor receptor-induced signaling by protein kinase C."
J. Biol. Chem. 269:21793-21802(1994) [PubMed] [Europe PMC] [Abstract]
"Identification of the major phosphorylation sites for protein kinase C in kit/stem cell factor receptor in vitro and in intact cells."
J. Biol. Chem. 270:14192-14200(1995) [PubMed] [Europe PMC] [Abstract]
"Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes."
J. Biol. Chem. 272:5915-5920(1997) [PubMed] [Europe PMC] [Abstract]
"Lyn associates with the juxtamembrane region of c-Kit and is activated by stem cell factor in hematopoietic cell lines and normal progenitor cells."
J. Biol. Chem. 272:27450-27455(1997) [PubMed] [Europe PMC] [Abstract]
"SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain."
Mol. Cell. Biol. 18:2089-2099(1998) [PubMed] [Europe PMC] [Abstract]
"Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor."
Biochem. J. 341:211-216(1999) [PubMed] [Europe PMC] [Abstract]
"The receptor protein tyrosine phosphatase, PTP-RO, is upregulated during megakaryocyte differentiation and is associated with the c-Kit receptor."
Blood 94:539-549(1999) [PubMed] [Europe PMC] [Abstract]
"The direct association of the multiple PDZ domain containing proteins (MUPP-1) with the human c-Kit C-terminus is regulated by tyrosine kinase activity."
FEBS Lett. 482:54-58(2000) [PubMed] [Europe PMC] [Abstract]
"Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling."
J. Biol. Chem. 277:13732-13738(2002) [PubMed] [Europe PMC] [Abstract]
"The adapter protein APS associates with the multifunctional docking sites Tyr-568 and Tyr-936 in c-Kit."
Biochem. J. 370:1033-1038(2003) [PubMed] [Europe PMC] [Abstract]
"Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk."
Exp. Cell Res. 288:110-118(2003) [PubMed] [Europe PMC] [Abstract]
"Src family kinases are involved in the differential signaling from two splice forms of c-Kit."
J. Biol. Chem. 278:9159-9166(2003) [PubMed] [Europe PMC] [Abstract]
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
"The tyrosine kinase FES is an essential effector of KITD816V proliferation signal."
Blood 110:2593-2599(2007) [PubMed] [Europe PMC] [Abstract]
"Grb2 mediates negative regulation of stem cell factor receptor/c-Kit signaling by recruitment of Cbl."
Exp. Cell Res. 313:3935-3942(2007) [PubMed] [Europe PMC] [Abstract]
"The D816V mutation of c-Kit circumvents a requirement for Src family kinases in c-Kit signal transduction."
J. Biol. Chem. 284:11039-11047(2009) [PubMed] [Europe PMC] [Abstract]
"Large-scale proteomics analysis of the human kinome."
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
"Expression of a truncated form of KIT tyrosine kinase in human spermatozoa correlates with sperm DNA integrity."
Hum. Reprod. 25:2188-2202(2010) [PubMed] [Europe PMC] [Abstract]
"Function of activation loop tyrosine phosphorylation in the mechanism of c-Kit auto-activation and its implication in sunitinib resistance."
J. Biochem. 147:601-609(2010) [PubMed] [Europe PMC] [Abstract]
"Mechanism of activation of human c-KIT kinase by internal tandem duplications of the juxtamembrane domain and point mutations at aspartic acid 816."
Biochem. Biophys. Res. Commun. 410:224-228(2011) [PubMed] [Europe PMC] [Abstract]
"Mechanisms of STAT protein activation by oncogenic KIT mutants in neoplastic mast cells."
J. Biol. Chem. 286:5956-5966(2011) [PubMed] [Europe PMC] [Abstract]
"Signal transduction via the stem cell factor receptor/c-Kit."
Cell. Mol. Life Sci. 61:2535-2548(2004) [PubMed] [Europe PMC] [Abstract]
"Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor."
Biochem. Biophys. Res. Commun. 337:1-13(2005) [PubMed] [Europe PMC] [Abstract]
"Normal and oncogenic forms of the receptor tyrosine kinase kit."
Stem Cells 23:16-43(2005) [PubMed] [Europe PMC] [Abstract]
"Regulation of hematopoietic stem cells by the steel factor/KIT signaling pathway."
Clin. Cancer Res. 14:1926-1930(2008) [PubMed] [Europe PMC] [Abstract]
"Tumor-intrinsic and -extrinsic roles of c-Kit: mast cells as the primary off-target of tyrosine kinase inhibitors."
Oncogene 30:757-769(2011) [PubMed] [Europe PMC] [Abstract]
"Structure of a c-kit product complex reveals the basis for kinase transactivation."
J. Biol. Chem. 278:31461-31464(2003) [PubMed] [Europe PMC] [Abstract]
"Structural basis for the autoinhibition and STI-571 inhibition of c-Kit tyrosine kinase."
J. Biol. Chem. 279:31655-31663(2004) [PubMed] [Europe PMC] [Abstract]
"Structural basis for activation of the receptor tyrosine kinase KIT by stem cell factor."
Cell 130:323-334(2007) [PubMed] [Europe PMC] [Abstract]
"KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients."
Proc. Natl. Acad. Sci. U.S.A. 106:1542-1547(2009) [PubMed] [Europe PMC] [Abstract]
"Structural basis for c-KIT inhibition by the suppressor of cytokine signaling 6 (SOCS6) ubiquitin ligase."
J. Biol. Chem. 286:480-490(2011) [PubMed] [Europe PMC] [Abstract]
"Human piebald trait resulting from a dominant negative mutant allele of the c-kit membrane receptor gene."
J. Clin. Invest. 89:1713-1717(1992) [PubMed] [Europe PMC] [Abstract]
"Dominant negative and loss of function mutations of the c-kit (mast/stem cell growth factor receptor) proto-oncogene in human piebaldism."
Am. J. Hum. Genet. 50:261-269(1992) [PubMed] [Europe PMC] [Abstract]
"Mutation of the KIT (mast/stem cell growth factor receptor) protooncogene in human piebaldism."
Proc. Natl. Acad. Sci. U.S.A. 88:8696-8699(1991) [PubMed] [Europe PMC] [Abstract]
"Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product."
J. Clin. Invest. 92:1736-1744(1993) [PubMed] [Europe PMC] [Abstract]
"Novel mutations of the KIT (mast/stem cell growth factor receptor) proto-oncogene in human piebaldism."
J. Invest. Dermatol. 101:22-25(1993) [PubMed] [Europe PMC] [Abstract]
"A 12-bp deletion (7818del12) in the c-kit protooncogene in a large Italian kindred with piebaldism."
Hum. Mutat. 6:343-345(1995) [PubMed] [Europe PMC] [Abstract]
"A new c-kit mutation in a case of aggressive mast cell disease."
Br. J. Haematol. 96:374-376(1997) [PubMed] [Europe PMC] [Abstract]
"Piebaldism with deafness: molecular evidence for an expanded syndrome."
Am. J. Med. Genet. 75:101-103(1998) [PubMed] [Europe PMC] [Abstract]
"c-kit activating mutations and mast cell proliferation in human leukemia."
Blood 92:701-702(1998) [PubMed] [Europe PMC] [Abstract]
"A novel KIT gene missense mutation in a Japanese family with piebaldism."
J. Invest. Dermatol. 111:337-338(1998) [PubMed] [Europe PMC] [Abstract]
"Familial gastrointestinal stromal tumours with germline mutation of the KIT gene."
Nat. Genet. 19:323-324(1998) [PubMed] [Europe PMC] [Abstract]
"Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors."
Science 279:577-580(1998) [PubMed] [Europe PMC] [Abstract]
"Activating c-kit gene mutations in human germ cell tumors."
Am. J. Pathol. 154:1643-1647(1999) [PubMed] [Europe PMC] [Abstract]
"Activating and dominant inactivating c-KIT catalytic domain mutations in distinct clinical forms of human mastocytosis."
Proc. Natl. Acad. Sci. U.S.A. 96:1609-1614(1999) [PubMed] [Europe PMC] [Abstract]
"Three novel mutations of the proto-oncogene KIT cause human piebaldism."
Am. J. Med. Genet. 95:79-81(2000) [PubMed] [Europe PMC] [Abstract]
"Germline mutation in the juxtamembrane domain of the kit gene in a family with gastrointestinal stromal tumors and urticaria pigmentosa."
Cancer 92:657-662(2001) [PubMed] [Europe PMC] [Abstract]
"A mutation-created novel intra-exonic pre-mRNA splice site causes constitutive activation of KIT in human gastrointestinal stromal tumors."
Oncogene 24:4271-4280(2005) [PubMed] [Europe PMC] [Abstract]
"Sequence analysis of the protein kinase gene family in human testicular germ-cell tumors of adolescents and adults."
Genes Chromosomes Cancer 45:42-46(2006) [PubMed] [Europe PMC] [Abstract]
"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]