TEK Tyrosine Kinase, Endothelial (Tie2)
CD202b; CD202-B; TEK; VMCM1; Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains 2; Venous Malformations Multiple Cutaneous And Mucosal
Tie-2 is a receptor tyrosine kinase that is expressed primarily on endothelial cells (ECs) and plays a critical role in vascular development. The Tie-2 gene encodes a protein of 1122 amino acids. The extracellular region has three distinct structural motifs including two immunoglobulin (Ig)-like loops separated by three EGF-like repeats, and three repeats with fibronectin type III homology located after the second Ig loop. The intracellular portion of Tie-2 contains two tyrosine kinase domains that, when phosphorylated, interact with a number of binding partners including Grb2, Grb7, Grb14, Shp2, the p85 subunit of phosphatidylinositol 3-kinase (PI3K), and Dok-R. Deletion of the last 16 amino acids of the intracellular C-terminus results in increased levels of autophosphorylation, suggesting that it may play an autoinhibitory role.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW587Hu01 | Recombinant TEK Tyrosine Kinase, Endothelial (Tie2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW587Hu01 | Monoclonal Antibody to TEK Tyrosine Kinase, Endothelial (Tie2) | WB; IHC; ICC; IP. |
| PAW587Hu01 | Polyclonal Antibody to TEK Tyrosine Kinase, Endothelial (Tie2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW587Hu01 | CLIA Kit for TEK Tyrosine Kinase, Endothelial (Tie2) | CLIA assay for Antigen Detection |
| ELW587Hu01 | ELISA Kit for TEK Tyrosine Kinase, Endothelial (Tie2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW587Mu01 | Recombinant TEK Tyrosine Kinase, Endothelial (Tie2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW587Mu01 | Monoclonal Antibody to TEK Tyrosine Kinase, Endothelial (Tie2) | WB; IHC; ICC; IP. |
| PAW587Mu01 | Polyclonal Antibody to TEK Tyrosine Kinase, Endothelial (Tie2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW587Mu01 | CLIA Kit for TEK Tyrosine Kinase, Endothelial (Tie2) | CLIA assay for Antigen Detection |
| ELW587Mu01 | ELISA Kit for TEK Tyrosine Kinase, Endothelial (Tie2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW587Ra01 | Recombinant TEK Tyrosine Kinase, Endothelial (Tie2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW587Ra01 | Monoclonal Antibody to TEK Tyrosine Kinase, Endothelial (Tie2) | WB; IHC; ICC; IP. |
| PAW587Ra01 | Polyclonal Antibody to TEK Tyrosine Kinase, Endothelial (Tie2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW587Ra01 | CLIA Kit for TEK Tyrosine Kinase, Endothelial (Tie2) | CLIA assay for Antigen Detection |
| ELW587Ra01 | ELISA Kit for TEK Tyrosine Kinase, Endothelial (Tie2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW587Ca01 | Recombinant TEK Tyrosine Kinase, Endothelial (Tie2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW587Ca01 | Monoclonal Antibody to TEK Tyrosine Kinase, Endothelial (Tie2) | WB; IHC; ICC; IP. |
| PAW587Ca01 | Polyclonal Antibody to TEK Tyrosine Kinase, Endothelial (Tie2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW587Ca01 | CLIA Kit for TEK Tyrosine Kinase, Endothelial (Tie2) | CLIA assay for Antigen Detection |
| ELW587Ca01 | ELISA Kit for TEK Tyrosine Kinase, Endothelial (Tie2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW587Po01 | Recombinant TEK Tyrosine Kinase, Endothelial (Tie2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW587Po01 | Monoclonal Antibody to TEK Tyrosine Kinase, Endothelial (Tie2) | WB; IHC; ICC; IP. |
| PAW587Po01 | Polyclonal Antibody to TEK Tyrosine Kinase, Endothelial (Tie2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW587Po01 | CLIA Kit for TEK Tyrosine Kinase, Endothelial (Tie2) | CLIA assay for Antigen Detection |
| ELW587Po01 | ELISA Kit for TEK Tyrosine Kinase, Endothelial (Tie2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW587Bo01 | Recombinant TEK Tyrosine Kinase, Endothelial (Tie2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW587Bo01 | Monoclonal Antibody to TEK Tyrosine Kinase, Endothelial (Tie2) | WB; IHC; ICC; IP. |
| PAW587Bo01 | Polyclonal Antibody to TEK Tyrosine Kinase, Endothelial (Tie2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW587Bo01 | CLIA Kit for TEK Tyrosine Kinase, Endothelial (Tie2) | CLIA assay for Antigen Detection |
| ELW587Bo01 | ELISA Kit for TEK Tyrosine Kinase, Endothelial (Tie2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW587Rb01 | Recombinant TEK Tyrosine Kinase, Endothelial (Tie2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW587Rb01 | Monoclonal Antibody to TEK Tyrosine Kinase, Endothelial (Tie2) | WB; IHC; ICC; IP. |
| PAW587Rb01 | Polyclonal Antibody to TEK Tyrosine Kinase, Endothelial (Tie2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW587Rb01 | CLIA Kit for TEK Tyrosine Kinase, Endothelial (Tie2) | CLIA assay for Antigen Detection |
| ELW587Rb01 | ELISA Kit for TEK Tyrosine Kinase, Endothelial (Tie2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW587Mo01 | Recombinant TEK Tyrosine Kinase, Endothelial (Tie2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW587Mo01 | Monoclonal Antibody to TEK Tyrosine Kinase, Endothelial (Tie2) | WB; IHC; ICC; IP. |
| PAW587Mo01 | Polyclonal Antibody to TEK Tyrosine Kinase, Endothelial (Tie2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW587Mo01 | CLIA Kit for TEK Tyrosine Kinase, Endothelial (Tie2) | CLIA assay for Antigen Detection |
| ELW587Mo01 | ELISA Kit for TEK Tyrosine Kinase, Endothelial (Tie2) | Enzyme-linked immunosorbent assay for Antigen Detection |
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Submitted (JAN-2010) to the PDB data bank
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