Tissue Inhibitors Of Metalloproteinase 2 (TIMP2)
CSC-21K; TIMP Metallopeptidase Inhibitor 2
TIMP2, is a member of the TIMP family. The proteins are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. In melanocytic cells TIMP2 gene expression may be regulated by MITF.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW586Hu01 | Recombinant Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW586Hu01 | Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | WB; IHC; ICC; IP. |
| PAW586Hu01 | Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW586Hu01 | CLIA Kit for Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | CLIA assay for Antigen Detection |
| ELW586Hu01 | ELISA Kit for Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW586Mu01 | Recombinant Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW586Mu01 | Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | WB; IHC; ICC; IP. |
| PAW586Mu01 | Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW586Mu01 | CLIA Kit for Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | CLIA assay for Antigen Detection |
| ELW586Mu01 | ELISA Kit for Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW586Ra01 | Recombinant Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW586Ra01 | Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | WB; IHC; ICC; IP. |
| PAW586Ra01 | Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW586Ra01 | CLIA Kit for Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | CLIA assay for Antigen Detection |
| ELW586Ra01 | ELISA Kit for Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW586Ca01 | Recombinant Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW586Ca01 | Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | WB; IHC; ICC; IP. |
| PAW586Ca01 | Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW586Ca01 | CLIA Kit for Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | CLIA assay for Antigen Detection |
| ELW586Ca01 | ELISA Kit for Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW586Po01 | Recombinant Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW586Po01 | Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | WB; IHC; ICC; IP. |
| PAW586Po01 | Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW586Po01 | CLIA Kit for Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | CLIA assay for Antigen Detection |
| ELW586Po01 | ELISA Kit for Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW586Bo01 | Recombinant Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW586Bo01 | Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | WB; IHC; ICC; IP. |
| PAW586Bo01 | Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW586Bo01 | CLIA Kit for Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | CLIA assay for Antigen Detection |
| ELW586Bo01 | ELISA Kit for Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW586Rb01 | Recombinant Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW586Rb01 | Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | WB; IHC; ICC; IP. |
| PAW586Rb01 | Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW586Rb01 | CLIA Kit for Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | CLIA assay for Antigen Detection |
| ELW586Rb01 | ELISA Kit for Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW586Mo01 | Recombinant Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW586Mo01 | Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | WB; IHC; ICC; IP. |
| PAW586Mo01 | Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW586Mo01 | CLIA Kit for Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | CLIA assay for Antigen Detection |
| ELW586Mo01 | ELISA Kit for Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Tissue inhibitor of metalloproteinases-2 (TIMP-2) mRNA expression in tumor cell lines and human tumor tissues."
J. Biol. Chem. 265:13933-13938(1990) [PubMed] [Europe PMC] [Abstract]
"cDNA cloning and expression of a metalloproteinase inhibitor related to tissue inhibitor of metalloproteinases."
Proc. Natl. Acad. Sci. U.S.A. 87:2800-2804(1990) [PubMed] [Europe PMC] [Abstract]
"Structure and characterization of the human tissue inhibitor of metalloproteinases-2 gene."
J. Biol. Chem. 271:25498-25505(1996) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Tissue inhibitor of metalloproteinase (TIMP-2). A new member of the metalloproteinase inhibitor family."
J. Biol. Chem. 264:17374-17378(1989) [PubMed] [Europe PMC] [Abstract]
"TIMP-2: identification and characterization of a new member of the metalloproteinase inhibitor family."
Matrix Suppl. 1:299-306(1992) [PubMed] [Europe PMC] [Abstract]
"Human 72-kilodalton type IV collagenase forms a complex with a tissue inhibitor of metalloproteases designated TIMP-2."
Proc. Natl. Acad. Sci. U.S.A. 86:8207-8211(1989) [PubMed] [Europe PMC] [Abstract]
"Isolation and characterization of tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) from human rheumatoid synovial fluid."
FEBS Lett. 296:16-20(1992) [PubMed] [Europe PMC] [Abstract]
"Characterization of the promoter of the gene encoding human tissue inhibitor of metalloproteinases-2 (TIMP-2)."
Gene 139:185-191(1994) [PubMed] [Europe PMC] [Abstract]
"Binding of tissue inhibitor of metalloproteinases 2 to two distinct sites on human 72-kDa gelatinase. Identification of a stabilization site."
J. Biol. Chem. 266:17972-17977(1991) [PubMed] [Europe PMC] [Abstract]
"Human cervical tumor cell (SiHa) surface alphavbeta3 integrin receptor has associated matrix metalloproteinase (MMP-2) activity."
J. Cancer Res. Clin. Oncol. 127:653-658(2001) [PubMed] [Europe PMC] [Abstract]
"Solution structure of the active domain of tissue inhibitor of metalloproteinases-2. A new member of the OB fold protein family."
Biochemistry 33:11745-11759(1994) [PubMed] [Europe PMC] [Abstract]
"High resolution structure of the N-terminal domain of tissue inhibitor of metalloproteinases-2 and characterization of its interaction site with matrix metalloproteinase-3."
J. Biol. Chem. 273:21736-21743(1998) [PubMed] [Europe PMC] [Abstract]
"Three-dimensional structure of human tissue inhibitor of metalloproteinases-2 at 2.1-A resolution."
J. Mol. Biol. 284:1133-1140(1998) [PubMed] [Europe PMC] [Abstract]
"Structural insight into the complex formation of latent matrix metalloproteinase 2 with tissue inhibitor of metalloproteinase 2."
Proc. Natl. Acad. Sci. U.S.A. 99:7414-7419(2002) [PubMed] [Europe PMC] [Abstract]