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Tumor Necrosis Factor Alpha (TNFa)

DIF; TNF-A; TNFSF2; Cachectin; Tumor Necrosis Factor Ligand Superfamily Member 2

TNFa  is synthesized as a 26 kDa, type II transmembrane protein that is 233 amino acids in length. It contains a 30 amino acid (aa) cytoplasmic domain, a 26 aa transmembrane segment, and a 177 aa extracellular region. TNFa is assembled intracellularly to form a transmembrane, non-covalently-linked homotrimeric protein. The 157 aa residue soluble form of TNFa (sTNF-αis released from the C-terminus of the transmembrane protein through the activity of TNFa-converting enzyme (TACE), a membrane -bound disintegrin metalloproteinase. Rat cells known to express TNF-αinclude B cells, colonic columnar epithelial cells, NK and CD3 CD56 hepatic natural T cells, macrophages, monocytes and monocyte-derived dendritic cells, CD4 and CD8 T cells, mast cells, neutrophils, keratinocytes, plasma cells, and adipocytes.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins W583Hu01 Recombinant Tumor Necrosis Factor Alpha (TNFa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Tumor Necrosis Factor Alpha (TNFa) Bioactivity
Antibodies MW583Hu22 Monoclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) WB; IHC; ICC; IP.
PW583Hu01 Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) WB; IHC; ICC; IF.
LW583Hu71 Biotin Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) Flow Cytometry;ICC/IF
Assay Kits KEW583Hu ELISA Kit for Tumor Necrosis Factor Alpha (TNFa) Enzyme-linked immunosorbent assay for Antigen Detection
KCW583Hu CLIA kit for Tumor Necrosis Factor Alpha (TNFa) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins W583Mu01 Recombinant Tumor Necrosis Factor Alpha (TNFa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Tumor Necrosis Factor Alpha (TNFa) Bioactivity
Antibodies MW583Mu21 Monoclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) WB; IHC; ICC; IP.
PW583Mu01 Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) WB; IHC; ICC; IF.
LW583Mu71 Biotin Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) Flow Cytometry;ICC/IF
Assay Kits KEW583Mu ELISA Kit for Tumor Necrosis Factor Alpha (TNFa) Enzyme-linked immunosorbent assay for Antigen Detection
KCW583Mu CLIA kit for Tumor Necrosis Factor Alpha (TNFa) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins W583Ra01 Recombinant Tumor Necrosis Factor Alpha (TNFa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Tumor Necrosis Factor Alpha (TNFa) Bioactivity
Antibodies MW583Ra21 Monoclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) WB; IHC; ICC; IP.
PW583Ra01 Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) WB; IHC; ICC; IF.
LW583Ra71 Biotin Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) Flow Cytometry
LW583Ra81 FITC Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) Flow Cytometry;ICC/IF
Assay Kits KEW583Ra ELISA Kit for Tumor Necrosis Factor Alpha (TNFa) Enzyme-linked immunosorbent assay for Antigen Detection
KCW583Ra CLIA kit for Tumor Necrosis Factor Alpha (TNFa) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins W583Ca01 Recombinant Tumor Necrosis Factor Alpha (TNFa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Tumor Necrosis Factor Alpha (TNFa) Bioactivity
Antibodies MW583Ca21 Monoclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) WB; IHC; ICC; IP.
PW583Ca01 Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) WB; IHC; ICC; IF.
LW583Ca71 Biotin Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) Flow Cytometry;ICC/IF
Assay Kits KEW583Ca ELISA Kit for Tumor Necrosis Factor Alpha (TNFa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Tumor Necrosis Factor Alpha (TNFa) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins W583Po01 Recombinant Tumor Necrosis Factor Alpha (TNFa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Tumor Necrosis Factor Alpha (TNFa) Bioactivity
Antibodies MW583Po21 Monoclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) WB; IHC; ICC; IP.
PW583Po01 Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) Flow Cytometry
LW583Po81 FITC Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) Flow Cytometry;ICC/IF
Assay Kits KEW583Po ELISA Kit for Tumor Necrosis Factor Alpha (TNFa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Tumor Necrosis Factor Alpha (TNFa) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins W583Bo01 Recombinant Tumor Necrosis Factor Alpha (TNFa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Tumor Necrosis Factor Alpha (TNFa) Bioactivity
Antibodies MW583Bo21 Monoclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) WB; IHC; ICC; IP.
PW583Bo01 Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) Flow Cytometry;ICC/IF
Assay Kits KEW583Bo ELISA Kit for Tumor Necrosis Factor Alpha (TNFa) Enzyme-linked immunosorbent assay for Antigen Detection
KCW583Bo CLIA kit for Tumor Necrosis Factor Alpha (TNFa) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins W583Si01 Recombinant Tumor Necrosis Factor Alpha (TNFa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Tumor Necrosis Factor Alpha (TNFa) Bioactivity
Antibodies MW583Si21 Monoclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) WB; IHC; ICC; IP.
PW583Si01 Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) Flow Cytometry
LW583Si81 FITC Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) Flow Cytometry;ICC/IF
Assay Kits KEW583Si ELISA Kit for Tumor Necrosis Factor Alpha (TNFa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Tumor Necrosis Factor Alpha (TNFa) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins W583Ga01 Recombinant Tumor Necrosis Factor Alpha (TNFa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Tumor Necrosis Factor Alpha (TNFa) Bioactivity
Antibodies NONE Monoclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) WB; IHC; ICC; IP.
PW583Ga01 Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) Flow Cytometry;ICC/IF
Assay Kits KEW583Ga ELISA Kit for Tumor Necrosis Factor Alpha (TNFa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Tumor Necrosis Factor Alpha (TNFa) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins W583Ov01 Recombinant Tumor Necrosis Factor Alpha (TNFa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Tumor Necrosis Factor Alpha (TNFa) Bioactivity
Antibodies MW583Ov21 Monoclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) WB; IHC; ICC; IP.
PW583Ov01 Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) WB; IHC; ICC; IF.
LW583Ov71 Biotin Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Tumor Necrosis Factor Alpha (TNFa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Tumor Necrosis Factor Alpha (TNFa) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins W583Rb01 Recombinant Tumor Necrosis Factor Alpha (TNFa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Tumor Necrosis Factor Alpha (TNFa) Bioactivity
Antibodies MW583Rb21 Monoclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) WB; IHC; ICC; IP.
PW583Rb51 Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) WB; IHC; ICC; IF.
LW583Rb71 Biotin Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) Flow Cytometry;ICC/IF
Assay Kits KEW583Rb ELISA Kit for Tumor Necrosis Factor Alpha (TNFa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Tumor Necrosis Factor Alpha (TNFa) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins W583Gu01 Recombinant Tumor Necrosis Factor Alpha (TNFa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Tumor Necrosis Factor Alpha (TNFa) Bioactivity
Antibodies MW583Gu21 Monoclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) WB; IHC; ICC; IP.
PW583Gu01 Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) Flow Cytometry;ICC/IF
Assay Kits KEW583Gu ELISA Kit for Tumor Necrosis Factor Alpha (TNFa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Tumor Necrosis Factor Alpha (TNFa) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins W583Eq01 Recombinant Tumor Necrosis Factor Alpha (TNFa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Tumor Necrosis Factor Alpha (TNFa) Bioactivity
Antibodies MW583Eq21 Monoclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) WB; IHC; ICC; IP.
PW583Eq01 Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) Flow Cytometry;ICC/IF
Assay Kits KEW583Eq ELISA Kit for Tumor Necrosis Factor Alpha (TNFa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Tumor Necrosis Factor Alpha (TNFa) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins W583Cp01 Recombinant Tumor Necrosis Factor Alpha (TNFa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Tumor Necrosis Factor Alpha (TNFa) Bioactivity
Antibodies MW583Cp21 Monoclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) WB; IHC; ICC; IP.
PW583Cp01 Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) Flow Cytometry;ICC/IF
Assay Kits KEW583Cp ELISA Kit for Tumor Necrosis Factor Alpha (TNFa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Tumor Necrosis Factor Alpha (TNFa) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Tumor Necrosis Factor Alpha (TNFa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Tumor Necrosis Factor Alpha (TNFa) Bioactivity
Antibodies NONE Monoclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Tumor Necrosis Factor Alpha (TNFa) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Tumor Necrosis Factor Alpha (TNFa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Tumor Necrosis Factor Alpha (TNFa) CLIA assay for Antigen Detection

Reference

"Tandem arrangement of genes coding for tumor necrosis factor (TNF-alpha) and lymphotoxin (TNF-beta) in the human genome."
Cold Spring Harb. Symp. Quant. Biol. 51:611-624(1986) [PubMed] [Europe PMC] [Abstract]

"Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin."
Nature 312:724-729(1984) [PubMed] [Europe PMC] [Abstract]

"Cloning and expression in Escherichia coli of the gene for human tumour necrosis factor."
Nature 313:803-806(1985) [PubMed] [Europe PMC] [Abstract]

"Human lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization."
Nucleic Acids Res. 13:6361-6373(1985) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning of the complementary DNA for human tumor necrosis factor."
Science 228:149-154(1985) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning and expression of human tumor necrosis factor and comparison with mouse tumor necrosis factor."
Eur. J. Biochem. 152:515-522(1985) [PubMed] [Europe PMC] [Abstract]

"Dense Alu clustering and a potential new member of the NF kappa B family within a 90 kilobase HLA class III segment."
Nat. Genet. 3:137-145(1993) [PubMed] [Europe PMC] [Abstract]

"A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC."
J. Immunol. 162:4745-4754(1999) [PubMed] [Europe PMC] [Abstract]

"Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"O-glycosylated species of natural human tumor-necrosis factor-alpha."
Eur. J. Biochem. 235:431-437(1996) [PubMed] [Europe PMC] [Abstract]

"Phosphorylation of the 26 kDa TNF precursor in monocytic cells and in transfected HeLa cells."
J. Inflamm. 45:152-160(1995) [PubMed] [Europe PMC] [Abstract]

"A casein kinase I motif present in the cytoplasmic domain of members of the tumour necrosis factor ligand family is implicated in 'reverse signalling'."
EMBO J. 18:2119-2126(1999) [PubMed] [Europe PMC] [Abstract]

"Localization of the active site of human tumour necrosis factor (hTNF) by mutational analysis."
EMBO J. 10:827-836(1991) [PubMed] [Europe PMC] [Abstract]

"Myristyl acylation of the tumor necrosis factor alpha precursor on specific lysine residues."
J. Exp. Med. 176:1053-1062(1992) [PubMed] [Europe PMC] [Abstract]

"Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha."
Nature 385:733-736(1997) [PubMed] [Europe PMC] [Abstract]

"A polymorphism that affects OCT-1 binding to the TNF promoter region is associated with severe malaria."
Nat. Genet. 22:145-150(1999) [PubMed] [Europe PMC] [Abstract]

"SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production."
Nat. Cell Biol. 8:843-848(2006) [PubMed] [Europe PMC] [Abstract]

"A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b."
Nat. Cell Biol. 8:894-896(2006) [PubMed] [Europe PMC] [Abstract]

"Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-alpha in rheumatoid arthritis."
Nat. Med. 19:322-328(2013) [PubMed] [Europe PMC] [Abstract]

"Structure of tumour necrosis factor."
Nature 338:225-228(1989) [PubMed] [Europe PMC] [Abstract]

"The structure of tumour necrosis factor -- implications for biological function."
J. Cell Sci. Suppl. 13:11-18(1990) [PubMed] [Europe PMC] [Abstract]

"The structure of tumor necrosis factor-alpha at 2.6-A resolution. Implications for receptor binding."
J. Biol. Chem. 264:17595-17605(1989) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of TNF-alpha mutant R31D with greater affinity for receptor R1 compared with R2."
Protein Eng. 10:1101-1107(1997) [PubMed] [Europe PMC] [Abstract]

"High resolution crystal structure of a human tumor necrosis factor-alpha mutant with low systemic toxicity."
J. Biol. Chem. 273:2153-2160(1998) [PubMed] [Europe PMC] [Abstract]

"Cytokine gene polymorphisms: association with psoriatic arthritis susceptibility and severity."
Arthritis Rheum. 48:1408-1413(2003) [PubMed] [Europe PMC] [Abstract]

"Association of TNF-alpha promoter polymorphisms with the clearance of hepatitis B virus infection."
Hum. Mol. Genet. 12:2541-2546(2003) [PubMed] [Europe PMC] [Abstract]