Thrombopoietin (TPO)
THPO; MGDF; MKCSF; ML; MPLLG; Myeloproliferative Leukemia Virus Oncogene Ligand; Megakaryocyte Growth And Development Factor; Megakaryocyte Stimulating Factor
Thrombopoietin (TPO), is a key regulator of megakaryocytopoiesis and thrombopoiesis in vitroand in vivo. TPO has been purified and cloned from several species including mouse, rat, and dog. The proteins from the various species are highly conserved, exhibiting from 69-75% sequence identity at the amino acid sequence level. Mature TPO can be divided into two domains: the amino-terminal half with homology to erythropoietin (Epo) and the carboxy-terminal half rich in serine, threonine and proline residues and containing seven potential N-linked glycosylation sites. The carboxy terminus domain of TPO has been shown to regulate the specific activity and circulating half-life of TPO. The carboxy-terminal may also have a role in promoting the efficient biosynthesis and secretion of TPO.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW581Hu01 | Recombinant Thrombopoietin (TPO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW581Hu01 | Monoclonal Antibody to Thrombopoietin (TPO) | WB; IHC; ICC; IP. |
| PAW581Hu01 | Polyclonal Antibody to Thrombopoietin (TPO) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW581Hu01 | CLIA Kit for Thrombopoietin (TPO) | CLIA assay for Antigen Detection |
| ELW581Hu01 | ELISA Kit for Thrombopoietin (TPO) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW581Mu01 | Recombinant Thrombopoietin (TPO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW581Mu01 | Monoclonal Antibody to Thrombopoietin (TPO) | WB; IHC; ICC; IP. |
| PAW581Mu01 | Polyclonal Antibody to Thrombopoietin (TPO) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW581Mu01 | CLIA Kit for Thrombopoietin (TPO) | CLIA assay for Antigen Detection |
| ELW581Mu01 | ELISA Kit for Thrombopoietin (TPO) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW581Ra01 | Recombinant Thrombopoietin (TPO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW581Ra01 | Monoclonal Antibody to Thrombopoietin (TPO) | WB; IHC; ICC; IP. |
| PAW581Ra01 | Polyclonal Antibody to Thrombopoietin (TPO) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW581Ra01 | CLIA Kit for Thrombopoietin (TPO) | CLIA assay for Antigen Detection |
| ELW581Ra01 | ELISA Kit for Thrombopoietin (TPO) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW581Ca01 | Recombinant Thrombopoietin (TPO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW581Ca01 | Monoclonal Antibody to Thrombopoietin (TPO) | WB; IHC; ICC; IP. |
| PAW581Ca01 | Polyclonal Antibody to Thrombopoietin (TPO) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW581Ca01 | CLIA Kit for Thrombopoietin (TPO) | CLIA assay for Antigen Detection |
| ELW581Ca01 | ELISA Kit for Thrombopoietin (TPO) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW581Po01 | Recombinant Thrombopoietin (TPO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW581Po01 | Monoclonal Antibody to Thrombopoietin (TPO) | WB; IHC; ICC; IP. |
| PAW581Po01 | Polyclonal Antibody to Thrombopoietin (TPO) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW581Po01 | CLIA Kit for Thrombopoietin (TPO) | CLIA assay for Antigen Detection |
| ELW581Po01 | ELISA Kit for Thrombopoietin (TPO) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW581Bo01 | Recombinant Thrombopoietin (TPO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW581Bo01 | Monoclonal Antibody to Thrombopoietin (TPO) | WB; IHC; ICC; IP. |
| PAW581Bo01 | Polyclonal Antibody to Thrombopoietin (TPO) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW581Bo01 | CLIA Kit for Thrombopoietin (TPO) | CLIA assay for Antigen Detection |
| ELW581Bo01 | ELISA Kit for Thrombopoietin (TPO) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW581Rb01 | Recombinant Thrombopoietin (TPO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW581Rb01 | Monoclonal Antibody to Thrombopoietin (TPO) | WB; IHC; ICC; IP. |
| PAW581Rb01 | Polyclonal Antibody to Thrombopoietin (TPO) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW581Rb01 | CLIA Kit for Thrombopoietin (TPO) | CLIA assay for Antigen Detection |
| ELW581Rb01 | ELISA Kit for Thrombopoietin (TPO) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW581Mo01 | Recombinant Thrombopoietin (TPO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW581Mo01 | Monoclonal Antibody to Thrombopoietin (TPO) | WB; IHC; ICC; IP. |
| PAW581Mo01 | Polyclonal Antibody to Thrombopoietin (TPO) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW581Mo01 | CLIA Kit for Thrombopoietin (TPO) | CLIA assay for Antigen Detection |
| ELW581Mo01 | ELISA Kit for Thrombopoietin (TPO) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand."
Nature 369:533-538(1994) [PubMed] [Europe PMC] [Abstract]
"Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl."
Cell 77:1117-1124(1994) [PubMed] [Europe PMC] [Abstract]
"Human thrombopoietin: gene structure, cDNA sequence, expression, and chromosomal localization."
Proc. Natl. Acad. Sci. U.S.A. 91:13023-13027(1994) [PubMed] [Europe PMC] [Abstract]
"Molecular cloning and chromosomal localization of the human thrombopoietin gene."
FEBS Lett. 353:57-61(1994) [PubMed] [Europe PMC] [Abstract]
"Genomic structure, chromosomal localization, and conserved alternative splice forms of thrombopoietin."
Blood 85:981-988(1995) [PubMed] [Europe PMC] [Abstract]
"Purification and characterization of thrombopoietin."
J. Biochem. 118:229-236(1995) [PubMed] [Europe PMC] [Abstract]
"Cloning and characterization of the human megakaryocyte growth and development factor (MGDF) gene."
J. Biol. Chem. 270:511-514(1995) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"An activating splice donor mutation in the thrombopoietin gene causes hereditary thrombocythaemia."
Nat. Genet. 18:49-52(1998) [PubMed] [Europe PMC] [Abstract]
"Peptide, disulfide, and glycosylation mapping of recombinant human thrombopoietin from ser1 to Arg246."
Biochemistry 35:14849-14861(1996) [PubMed] [Europe PMC] [Abstract]
"Structure of the receptor-binding domain of human thrombopoietin determined by complexation with a neutralizing antibody fragment."
Proc. Natl. Acad. Sci. U.S.A. 101:1816-1821(2004) [PubMed] [Europe PMC] [Abstract]