Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A)
CD261; TNFRSF10-A; APO2; DR4; TRAILR1; Death Receptor 4; TNF-Related Apoptosis-Inducing Ligand Receptor 1
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.
Pan et al. (1997) found that, as with FAS, TNFR1, and DR3, overexpression of DR4 induced apoptosis. However, unlike the other 3 death receptors, DR4 did not use FADD to transmit the death signal, suggesting the use of distinct proximal signaling machinery.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW580Hu01 | Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW580Hu01 | Monoclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A) | WB; IHC; ICC; IP. |
| PAW580Hu01 | Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW580Hu01 | CLIA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A) | CLIA assay for Antigen Detection |
| ELW580Hu01 | ELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW580Mu01 | Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW580Mu01 | Monoclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A) | WB; IHC; ICC; IP. |
| PAW580Mu01 | Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW580Mu01 | CLIA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A) | CLIA assay for Antigen Detection |
| ELW580Mu01 | ELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW580Ra01 | Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW580Ra01 | Monoclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A) | WB; IHC; ICC; IP. |
| PAW580Ra01 | Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW580Ra01 | CLIA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A) | CLIA assay for Antigen Detection |
| ELW580Ra01 | ELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW580Ca01 | Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW580Ca01 | Monoclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A) | WB; IHC; ICC; IP. |
| PAW580Ca01 | Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW580Ca01 | CLIA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A) | CLIA assay for Antigen Detection |
| ELW580Ca01 | ELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW580Po01 | Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW580Po01 | Monoclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A) | WB; IHC; ICC; IP. |
| PAW580Po01 | Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW580Po01 | CLIA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A) | CLIA assay for Antigen Detection |
| ELW580Po01 | ELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW580Bo01 | Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW580Bo01 | Monoclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A) | WB; IHC; ICC; IP. |
| PAW580Bo01 | Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW580Bo01 | CLIA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A) | CLIA assay for Antigen Detection |
| ELW580Bo01 | ELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW580Rb01 | Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW580Rb01 | Monoclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A) | WB; IHC; ICC; IP. |
| PAW580Rb01 | Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW580Rb01 | CLIA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A) | CLIA assay for Antigen Detection |
| ELW580Rb01 | ELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW580Mo01 | Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW580Mo01 | Monoclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A) | WB; IHC; ICC; IP. |
| PAW580Mo01 | Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW580Mo01 | CLIA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A) | CLIA assay for Antigen Detection |
| ELW580Mo01 | ELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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Science 276:111-113(1997) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway."
Immunity 7:821-830(1997) [PubMed] [Europe PMC] [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
"Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane."
Apoptosis 13:423-436(2008) [PubMed] [Europe PMC] [Abstract]
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
"Human cytomegalovirus glycoprotein UL141 targets the TRAIL death receptors to thwart host innate antiviral defenses."
Cell Host Microbe 13:324-335(2013) [PubMed] [Europe PMC] [Abstract]