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Kallikrein 3 (KLK3)

APS; KLK2A1; PSA; HK3; KLKB1; Seminin; Prostate Specific Antigen; Kallikrein-Related Peptidase 3; Semenogelase, g-Seminoprotein; P-30 Antigen; Plasma kallikrein

Human prostate-specific antigen (APS) is a kallikrein-like protease present in seminal plasma. It is a single-chain glycoprotein with a molecular mass of about 33 kD that may function normally in the liquefaction of seminal coagulum. Radioimmunoassay of serum levels of this antigen (called PSA in the clinical setting) is useful in the diagnosis and monitoring of prostatic carcinoma. The full-length KLK3 protein contains 261 amino acids. It has a putative signal peptide, followed by a short activating peptide and the protease domain, which includes the catalytic triad of his65, asp120, and ser213. RT-PCR of 35 adult and fetal tissues detected highest expression in prostate. Expression was weak in colon, mammary gland, and parotid, and little to no expression was detected in other tissues examined.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins W568Hu01 Recombinant Kallikrein 3 (KLK3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Kallikrein 3 (KLK3) Bioactivity
Antibodies MW568Hu22 Monoclonal Antibody to Kallikrein 3 (KLK3) WB; IHC; ICC; IP.
PW568Hu01 Polyclonal Antibody to Kallikrein 3 (KLK3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) Flow Cytometry;ICC/IF
Assay Kits KEW568Hu ELISA Kit for Kallikrein 3 (KLK3) Enzyme-linked immunosorbent assay for Antigen Detection
KCW568Hu CLIA kit for Kallikrein 3 (KLK3) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins W568Mu01 Recombinant Kallikrein 3 (KLK3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Kallikrein 3 (KLK3) Bioactivity
Antibodies NONE Monoclonal Antibody to Kallikrein 3 (KLK3) WB; IHC; ICC; IP.
PW568Mu01 Polyclonal Antibody to Kallikrein 3 (KLK3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) Flow Cytometry;ICC/IF
Assay Kits KEW568Mu ELISA Kit for Kallikrein 3 (KLK3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Kallikrein 3 (KLK3) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins W568Ra01 Recombinant Kallikrein 3 (KLK3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Kallikrein 3 (KLK3) Bioactivity
Antibodies MW568Ra21 Monoclonal Antibody to Kallikrein 3 (KLK3) WB; IHC; ICC; IP.
PW568Ra01 Polyclonal Antibody to Kallikrein 3 (KLK3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) Flow Cytometry;ICC/IF
Assay Kits KEW568Ra ELISA Kit for Kallikrein 3 (KLK3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Kallikrein 3 (KLK3) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Kallikrein 3 (KLK3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Kallikrein 3 (KLK3) Bioactivity
Antibodies NONE Monoclonal Antibody to Kallikrein 3 (KLK3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Kallikrein 3 (KLK3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Kallikrein 3 (KLK3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Kallikrein 3 (KLK3) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Kallikrein 3 (KLK3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Kallikrein 3 (KLK3) Bioactivity
Antibodies NONE Monoclonal Antibody to Kallikrein 3 (KLK3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Kallikrein 3 (KLK3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Kallikrein 3 (KLK3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Kallikrein 3 (KLK3) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Kallikrein 3 (KLK3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Kallikrein 3 (KLK3) Bioactivity
Antibodies NONE Monoclonal Antibody to Kallikrein 3 (KLK3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Kallikrein 3 (KLK3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Kallikrein 3 (KLK3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Kallikrein 3 (KLK3) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins W568Si01 Recombinant Kallikrein 3 (KLK3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Kallikrein 3 (KLK3) Bioactivity
Antibodies NONE Monoclonal Antibody to Kallikrein 3 (KLK3) WB; IHC; ICC; IP.
PW568Si01 Polyclonal Antibody to Kallikrein 3 (KLK3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Kallikrein 3 (KLK3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Kallikrein 3 (KLK3) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Kallikrein 3 (KLK3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Kallikrein 3 (KLK3) Bioactivity
Antibodies NONE Monoclonal Antibody to Kallikrein 3 (KLK3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Kallikrein 3 (KLK3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Kallikrein 3 (KLK3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Kallikrein 3 (KLK3) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Kallikrein 3 (KLK3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Kallikrein 3 (KLK3) Bioactivity
Antibodies NONE Monoclonal Antibody to Kallikrein 3 (KLK3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Kallikrein 3 (KLK3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Kallikrein 3 (KLK3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Kallikrein 3 (KLK3) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Kallikrein 3 (KLK3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Kallikrein 3 (KLK3) Bioactivity
Antibodies NONE Monoclonal Antibody to Kallikrein 3 (KLK3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Kallikrein 3 (KLK3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Kallikrein 3 (KLK3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Kallikrein 3 (KLK3) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Kallikrein 3 (KLK3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Kallikrein 3 (KLK3) Bioactivity
Antibodies NONE Monoclonal Antibody to Kallikrein 3 (KLK3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Kallikrein 3 (KLK3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Kallikrein 3 (KLK3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Kallikrein 3 (KLK3) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Kallikrein 3 (KLK3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Kallikrein 3 (KLK3) Bioactivity
Antibodies NONE Monoclonal Antibody to Kallikrein 3 (KLK3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Kallikrein 3 (KLK3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Kallikrein 3 (KLK3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Kallikrein 3 (KLK3) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Kallikrein 3 (KLK3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Kallikrein 3 (KLK3) Bioactivity
Antibodies NONE Monoclonal Antibody to Kallikrein 3 (KLK3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Kallikrein 3 (KLK3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Kallikrein 3 (KLK3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Kallikrein 3 (KLK3) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Kallikrein 3 (KLK3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Kallikrein 3 (KLK3) Bioactivity
Antibodies NONE Monoclonal Antibody to Kallikrein 3 (KLK3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Kallikrein 3 (KLK3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Kallikrein 3 (KLK3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Kallikrein 3 (KLK3) CLIA assay for Antigen Detection

Reference

"Molecular cloning of human prostate specific antigen cDNA."
FEBS Lett. 214:317-322(1987) [PubMed] [Europe PMC] [Abstract]

"Human prostate specific antigen (PSA) gene: structure and linkage to the kallikrein-like gene, hGK-1."
Nucleic Acids Res. 17:2137-2137(1989) [PubMed] [Europe PMC] [Abstract]

"Genomic sequence of human prostate specific antigen (PSA)."
Nucleic Acids Res. 17:3981-3981(1989) [PubMed] [Europe PMC] [Abstract]

"Characterization of the gene for prostate-specific antigen, a human glandular kallikrein."
Biochem. Biophys. Res. Commun. 161:1151-1159(1989) [PubMed] [Europe PMC] [Abstract]

"cDNA coding for the entire human prostate specific antigen shows high homologies to the human tissue kallikrein genes."
Biochem. Biophys. Res. Commun. 160:903-910(1989) [PubMed] [Europe PMC] [Abstract]

"Characterization of the prostate-specific antigen gene: a novel human kallikrein-like gene."
Biochem. Biophys. Res. Commun. 159:95-102(1989) [PubMed] [Europe PMC] [Abstract]

"A comparative analysis of prostate-specific antigen gene sequence in benign and malignant prostate tissue."
Urology 47:795-800(1996) [PubMed] [Europe PMC] [Abstract]

"Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region."
Gene 257:119-130(2000) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Molecular characterization of prostate-specific antigen messenger RNA expressed in breast tumors."
Cancer Res. 54:6344-6347(1994) [PubMed] [Europe PMC] [Abstract]

"Sequence of a cDNA clone encompassing the complete mature human prostate specific antigen (PSA) and an unspliced leader sequence."
Nucleic Acids Res. 16:6226-6226(1988) [PubMed] [Europe PMC] [Abstract]

"Human prostate-specific antigen: structural and functional similarity with serine proteases."
Proc. Natl. Acad. Sci. U.S.A. 83:3166-3170(1986) [PubMed] [Europe PMC] [Abstract]

"Isolation, characterization and amino-acid sequence of gamma-seminoprotein, a glycoprotein from human seminal plasma."
Eur. J. Biochem. 170:111-120(1987) [PubMed] [Europe PMC] [Abstract]

"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]

"Identification of a novel proteoform of prostate specific antigen (SNP-L132I) in clinical samples by multiple reaction monitoring."
Mol. Cell. Proteomics 12:2761-2773(2013) [PubMed] [Europe PMC] [Abstract]

"Functionally active protein C inhibitor/plasminogen activator inhibitor-3 (PCI/PAI-3) is secreted in seminal vesicles, occurs at high concentrations in human seminal plasma and complexes with prostate-specific antigen."
Thromb. Res. 64:309-320(1991) [PubMed] [Europe PMC] [Abstract]

"A structural model for the prostate disease marker, human prostate-specific antigen."
Protein Sci. 3:2033-2044(1994) [PubMed] [Europe PMC] [Abstract]

"Substrate specificity of prostate-specific antigen (PSA)."
Chem. Biol. 5:475-488(1998) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of a ternary complex between human prostate-specific antigen, its substrate acyl intermediate and an activating antibody."
J. Mol. Biol. 376:1021-1033(2008) [PubMed] [Europe PMC] [Abstract]