Kallikrein 3 (KLK3)
APS; KLK2A1; PSA; HK3; KLKB1; Seminin; Prostate Specific Antigen; Kallikrein-Related Peptidase 3; Semenogelase, g-Seminoprotein; P-30 Antigen; Plasma kallikrein
Human prostate-specific antigen (APS) is a kallikrein-like protease present in seminal plasma. It is a single-chain glycoprotein with a molecular mass of about 33 kD that may function normally in the liquefaction of seminal coagulum. Radioimmunoassay of serum levels of this antigen (called PSA in the clinical setting) is useful in the diagnosis and monitoring of prostatic carcinoma. The full-length KLK3 protein contains 261 amino acids. It has a putative signal peptide, followed by a short activating peptide and the protease domain, which includes the catalytic triad of his65, asp120, and ser213. RT-PCR of 35 adult and fetal tissues detected highest expression in prostate. Expression was weak in colon, mammary gland, and parotid, and little to no expression was detected in other tissues examined.
Organism species: Homo sapiens (Human)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | W568Hu01 | Recombinant Kallikrein 3 (KLK3) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Kallikrein 3 (KLK3) | Bioactivity | |
Antibodies | MW568Hu22 | Monoclonal Antibody to Kallikrein 3 (KLK3) | WB; IHC; ICC; IP. |
PW568Hu01 | Polyclonal Antibody to Kallikrein 3 (KLK3) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | Flow Cytometry;ICC/IF | |
Assay Kits | KEW568Hu | ELISA Kit for Kallikrein 3 (KLK3) | Enzyme-linked immunosorbent assay for Antigen Detection |
KCW568Hu | CLIA kit for Kallikrein 3 (KLK3) | CLIA assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | W568Mu01 | Recombinant Kallikrein 3 (KLK3) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Kallikrein 3 (KLK3) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Kallikrein 3 (KLK3) | WB; IHC; ICC; IP. |
PW568Mu01 | Polyclonal Antibody to Kallikrein 3 (KLK3) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | Flow Cytometry;ICC/IF | |
Assay Kits | KEW568Mu | ELISA Kit for Kallikrein 3 (KLK3) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Kallikrein 3 (KLK3) | CLIA assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | W568Ra01 | Recombinant Kallikrein 3 (KLK3) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Kallikrein 3 (KLK3) | Bioactivity | |
Antibodies | MW568Ra21 | Monoclonal Antibody to Kallikrein 3 (KLK3) | WB; IHC; ICC; IP. |
PW568Ra01 | Polyclonal Antibody to Kallikrein 3 (KLK3) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | Flow Cytometry;ICC/IF | |
Assay Kits | KEW568Ra | ELISA Kit for Kallikrein 3 (KLK3) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Kallikrein 3 (KLK3) | CLIA assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Kallikrein 3 (KLK3) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Kallikrein 3 (KLK3) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Kallikrein 3 (KLK3) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Kallikrein 3 (KLK3) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Kallikrein 3 (KLK3) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Kallikrein 3 (KLK3) | CLIA assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Kallikrein 3 (KLK3) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Kallikrein 3 (KLK3) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Kallikrein 3 (KLK3) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Kallikrein 3 (KLK3) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Kallikrein 3 (KLK3) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Kallikrein 3 (KLK3) | CLIA assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Kallikrein 3 (KLK3) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Kallikrein 3 (KLK3) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Kallikrein 3 (KLK3) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Kallikrein 3 (KLK3) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Kallikrein 3 (KLK3) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Kallikrein 3 (KLK3) | CLIA assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | W568Si01 | Recombinant Kallikrein 3 (KLK3) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Kallikrein 3 (KLK3) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Kallikrein 3 (KLK3) | WB; IHC; ICC; IP. |
PW568Si01 | Polyclonal Antibody to Kallikrein 3 (KLK3) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Kallikrein 3 (KLK3) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Kallikrein 3 (KLK3) | CLIA assay for Antigen Detection |
Organism species: Chicken (Gallus)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Kallikrein 3 (KLK3) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Kallikrein 3 (KLK3) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Kallikrein 3 (KLK3) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Kallikrein 3 (KLK3) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Kallikrein 3 (KLK3) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Kallikrein 3 (KLK3) | CLIA assay for Antigen Detection |
Organism species: Ovis aries; Ovine (Sheep)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Kallikrein 3 (KLK3) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Kallikrein 3 (KLK3) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Kallikrein 3 (KLK3) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Kallikrein 3 (KLK3) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Kallikrein 3 (KLK3) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Kallikrein 3 (KLK3) | CLIA assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Kallikrein 3 (KLK3) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Kallikrein 3 (KLK3) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Kallikrein 3 (KLK3) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Kallikrein 3 (KLK3) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Kallikrein 3 (KLK3) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Kallikrein 3 (KLK3) | CLIA assay for Antigen Detection |
Organism species: Cavia (Guinea pig )
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Kallikrein 3 (KLK3) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Kallikrein 3 (KLK3) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Kallikrein 3 (KLK3) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Kallikrein 3 (KLK3) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Kallikrein 3 (KLK3) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Kallikrein 3 (KLK3) | CLIA assay for Antigen Detection |
Organism species: Equus caballus; Equine (Horse)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Kallikrein 3 (KLK3) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Kallikrein 3 (KLK3) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Kallikrein 3 (KLK3) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Kallikrein 3 (KLK3) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Kallikrein 3 (KLK3) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Kallikrein 3 (KLK3) | CLIA assay for Antigen Detection |
Organism species: Capra hircus; Caprine (Goat)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Kallikrein 3 (KLK3) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Kallikrein 3 (KLK3) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Kallikrein 3 (KLK3) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Kallikrein 3 (KLK3) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Kallikrein 3 (KLK3) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Kallikrein 3 (KLK3) | CLIA assay for Antigen Detection |
Organism species: Pan-species (General)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Kallikrein 3 (KLK3) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Kallikrein 3 (KLK3) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Kallikrein 3 (KLK3) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Kallikrein 3 (KLK3) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Kallikrein 3 (KLK3) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Kallikrein 3 (KLK3) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Kallikrein 3 (KLK3) | CLIA assay for Antigen Detection |
Reference
"Molecular cloning of human prostate specific antigen cDNA."
FEBS Lett. 214:317-322(1987) [PubMed] [Europe PMC] [Abstract]
"Human prostate specific antigen (PSA) gene: structure and linkage to the kallikrein-like gene, hGK-1."
Nucleic Acids Res. 17:2137-2137(1989) [PubMed] [Europe PMC] [Abstract]
"Genomic sequence of human prostate specific antigen (PSA)."
Nucleic Acids Res. 17:3981-3981(1989) [PubMed] [Europe PMC] [Abstract]
"Characterization of the gene for prostate-specific antigen, a human glandular kallikrein."
Biochem. Biophys. Res. Commun. 161:1151-1159(1989) [PubMed] [Europe PMC] [Abstract]
"cDNA coding for the entire human prostate specific antigen shows high homologies to the human tissue kallikrein genes."
Biochem. Biophys. Res. Commun. 160:903-910(1989) [PubMed] [Europe PMC] [Abstract]
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"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
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"Functionally active protein C inhibitor/plasminogen activator inhibitor-3 (PCI/PAI-3) is secreted in seminal vesicles, occurs at high concentrations in human seminal plasma and complexes with prostate-specific antigen."
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"A structural model for the prostate disease marker, human prostate-specific antigen."
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"Substrate specificity of prostate-specific antigen (PSA)."
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"Crystal structure of a ternary complex between human prostate-specific antigen, its substrate acyl intermediate and an activating antibody."
J. Mol. Biol. 376:1021-1033(2008) [PubMed] [Europe PMC] [Abstract]