Alpha-Fetoprotein (aFP)

A-FP; FETA; HPAFP; Alpha-Fetoglobulin; Alpha-1-fetoprotein

SPN	W567
HGNC	317
MGI	87951
PubMed	67821
RGD	2065
UniProt	P02771
Wiki	AFP

AFP) is a glycoprotein with a molecular weight of between 65,000 and 70,000 daltons including 4% of carbohydrate . During fetal development, AFP maintains high levels in the serum and drops to very low levels throughout the remainder of life.

AFP is elevated in the malignant diseases of hepatocellular, testicular nonseminomatous origin, and occasionally of other entodermal origin. AFP may be slightly elevated or persisted in the patients with large hepatic metastases or viral hepatitis. AFP measurement is widely accepted as tumor marker and for monitoring the therapeutic effectiveness of hepatocellular cancer and nonseminomatous testicular cancer .

Reference

"Primary structures of human alpha-fetoprotein and its mRNA."
Proc. Natl. Acad. Sci. U.S.A. 80:4604-4608(1983) [PubMed] [Europe PMC] [Abstract]

"Structure, polymorphism, and novel repeated DNA elements revealed by a complete sequence of the human alpha-fetoprotein gene."
Biochemistry 26:1332-1343(1987) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The human alpha-fetoprotein gene. Sequence organization and the 5' flanking region."
J. Biol. Chem. 260:5055-5060(1985) [PubMed] [Europe PMC] [Abstract]

"A G-->A substitution in an HNF I binding site in the human alpha-fetoprotein gene is associated with hereditary persistence of alpha-fetoprotein (HPAFP)."
Hum. Mol. Genet. 2:379-384(1993) [PubMed] [Europe PMC] [Abstract]

, Submitted (MAR-2007) to UniProtKB

"Structure and evolution of human alpha-fetoprotein deduced from partial sequence of cloned cDNA."
Gene 20:415-422(1982) [PubMed] [Europe PMC] [Abstract]

"Human alpha-fetoprotein primary structure: a mass spectrometric study."
Biochemistry 30:5061-5066(1991) [PubMed] [Europe PMC] [Abstract]

"Studies on human alpha-fetoprotein. Isolation and characterization of monomeric and polymeric forms and amino-terminal sequence analysis."
Biochim. Biophys. Acta 493:418-428(1977) [PubMed] [Europe PMC] [Abstract]

"Comparative chemical structures of human alpha-fetoproteins from fetal serum and from ascites fluid of a patient with hepatoma."
Cancer Res. 37:3663-3667(1977) [PubMed] [Europe PMC] [Abstract]

"Alpha fetoprotein: structure and expression in man and inbred mouse strains under normal conditions and liver injury."
Johns Hopkins Med. J. Suppl. 3:249-255(1974) [PubMed] [Europe PMC] [Abstract]

"Copper(II)-binding ability of human alpha-fetoprotein."
Cancer Res. 38:3483-3486(1978) [PubMed] [Europe PMC] [Abstract]

"Alpha-fetoprotein as a carrier protein in plasma and its bilirubin-binding ability."
Cancer Res. 39:3571-3574(1979) [PubMed] [Europe PMC] [Abstract]

"Tyrosine sulfation of proteins from the human hepatoma cell line HepG2."
Proc. Natl. Acad. Sci. U.S.A. 82:7160-7164(1985) [PubMed] [Europe PMC] [Abstract]

"Congenital deficiency of alpha feto-protein."
Eur. J. Hum. Genet. 12:871-874(2004) [PubMed] [Europe PMC] [Abstract]

"A new mutation in the AFP gene responsible for a total absence of alpha feto-protein on second trimester maternal serum screening for Down syndrome."
Eur. J. Hum. Genet. 17:387-390(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]