Carbohydrate Antigen 125 (CA125)

MUC16; Cancer Antigen 125; Mucin 16,Cell Surface Associated; Ovarian Cancer-Related Tumor Marker CA125; Ovarian Carcinoma Antigen CA125

SPN	W566
HGNC	15582
MGI	1920982
PubMed	2651469
UniProt	Q8WXI7
Wiki	CA-125

CA-125 has found application as a tumor marker or biomarker that may be elevated in the blood of some patients with specific types of cancers.CA-125 is clinically approved for following the response to treatment and predicting prognosis after treatment. It is especially useful for detecting the recurrence of ovarian cancer. Its potential role for the early detection of ovarian cancer is controversial and has not yet been adopted for widespread screening efforts in asymptomatic women. The key problems in using the CA-125 test as a screening tool are its lack of sensitivity and its inability to detect early stage cancers. An operation would be necessary to confirm that a woman with elevated CA-125 has ovarian cancer, with the associated risk of death from major surgery.

Reference

"The CA 125 gene: a newly discovered extension of the glycosylated N-terminal domain doubles the size of this extracellular superstructure."
Tumor Biol. 23:154-169(2002) [PubMed] [Europe PMC] [Abstract]

"The CA 125 gene: an extracellular superstructure dominated by repeat sequences."
Tumor Biol. 22:348-366(2001) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning of the CA125 ovarian cancer antigen: identification as a new mucin, MUC16."
J. Biol. Chem. 276:27371-27375(2001) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"CA125 phosphorylation is associated with its secretion from the WISH human amnion cell line."
Tumor Biol. 18:278-289(1997) [PubMed] [Europe PMC] [Abstract]

"Characterization of the oligosaccharides associated with the human ovarian tumor marker CA125."
J. Biol. Chem. 278:28619-28634(2003) [PubMed] [Europe PMC] [Abstract]

"Binding of ovarian cancer antigen CA125/MUC16 to mesothelin mediates cell adhesion."
J. Biol. Chem. 279:9190-9198(2004) [PubMed] [Europe PMC] [Abstract]

"Introducing the MUC16 gene: implications for prevention and early detection in epithelial ovarian cancer."
Biol. Res. Nurs. 6:262-267(2005) [PubMed] [Europe PMC] [Abstract]

"Mucin characteristics of human corneal-limbal epithelial cells that exclude the rose bengal anionic dye."
Invest. Ophthalmol. Vis. Sci. 47:113-119(2006) [PubMed] [Europe PMC] [Abstract]