Alpha-2-Plasmin Inhibitor (a2PI)
SERPINF2; AAP; A2-PI; API; PLI; A2AP; Alpha 2 Antiplasmin; Serpin Peptidase Inhibitor Clade F Member 2; Pigment Epithelium Derived Factor
An inherited hemorrhagic diathesis due to plasmin inhibitor deficiency was described by Koie et al. (1978) in a 25-year-old Okinawa man. He had suffered prolonged bleeding and ecchymoses after minor trauma, spontaneous joint hemorrhage, and one episode of hemothorax. The bleeding episodes were reduced in frequency and severity by an antiplasminic drug. Laboratory abnormalities were limited to shortened euglobulin-lysis time and whole blood clot lysis time. No circulating alpha-2-plasmin inhibitor was found in the plasma. Even though only one case was observed, autosomal recessive inheritance was undoubted because the parents were consanguineous and both had plasma antiplasmin levels about half normal. The authors called the condition Miyasato disease after the proband's surname.
Organism species: Homo sapiens (Human)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPW561Hu01 | Recombinant Alpha-2-Plasmin Inhibitor (a2PI) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAW561Hu01 | Monoclonal Antibody to Alpha-2-Plasmin Inhibitor (a2PI) | WB; IHC; ICC; IP. |
PAW561Hu01 | Polyclonal Antibody to Alpha-2-Plasmin Inhibitor (a2PI) | WB; IHC; ICC; IF. | |
Assay Kits | CLW561Hu01 | CLIA Kit for Alpha-2-Plasmin Inhibitor (a2PI) | CLIA assay for Antigen Detection |
ELW561Hu01 | ELISA Kit for Alpha-2-Plasmin Inhibitor (a2PI) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPW561Mu01 | Recombinant Alpha-2-Plasmin Inhibitor (a2PI) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAW561Mu01 | Monoclonal Antibody to Alpha-2-Plasmin Inhibitor (a2PI) | WB; IHC; ICC; IP. |
PAW561Mu01 | Polyclonal Antibody to Alpha-2-Plasmin Inhibitor (a2PI) | WB; IHC; ICC; IF. | |
Assay Kits | CLW561Mu01 | CLIA Kit for Alpha-2-Plasmin Inhibitor (a2PI) | CLIA assay for Antigen Detection |
ELW561Mu01 | ELISA Kit for Alpha-2-Plasmin Inhibitor (a2PI) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPW561Ra01 | Recombinant Alpha-2-Plasmin Inhibitor (a2PI) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAW561Ra01 | Monoclonal Antibody to Alpha-2-Plasmin Inhibitor (a2PI) | WB; IHC; ICC; IP. |
PAW561Ra01 | Polyclonal Antibody to Alpha-2-Plasmin Inhibitor (a2PI) | WB; IHC; ICC; IF. | |
Assay Kits | CLW561Ra01 | CLIA Kit for Alpha-2-Plasmin Inhibitor (a2PI) | CLIA assay for Antigen Detection |
ELW561Ra01 | ELISA Kit for Alpha-2-Plasmin Inhibitor (a2PI) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPW561Ca01 | Recombinant Alpha-2-Plasmin Inhibitor (a2PI) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAW561Ca01 | Monoclonal Antibody to Alpha-2-Plasmin Inhibitor (a2PI) | WB; IHC; ICC; IP. |
PAW561Ca01 | Polyclonal Antibody to Alpha-2-Plasmin Inhibitor (a2PI) | WB; IHC; ICC; IF. | |
Assay Kits | CLW561Ca01 | CLIA Kit for Alpha-2-Plasmin Inhibitor (a2PI) | CLIA assay for Antigen Detection |
ELW561Ca01 | ELISA Kit for Alpha-2-Plasmin Inhibitor (a2PI) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPW561Po01 | Recombinant Alpha-2-Plasmin Inhibitor (a2PI) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAW561Po01 | Monoclonal Antibody to Alpha-2-Plasmin Inhibitor (a2PI) | WB; IHC; ICC; IP. |
PAW561Po01 | Polyclonal Antibody to Alpha-2-Plasmin Inhibitor (a2PI) | WB; IHC; ICC; IF. | |
Assay Kits | CLW561Po01 | CLIA Kit for Alpha-2-Plasmin Inhibitor (a2PI) | CLIA assay for Antigen Detection |
ELW561Po01 | ELISA Kit for Alpha-2-Plasmin Inhibitor (a2PI) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPW561Bo01 | Recombinant Alpha-2-Plasmin Inhibitor (a2PI) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAW561Bo01 | Monoclonal Antibody to Alpha-2-Plasmin Inhibitor (a2PI) | WB; IHC; ICC; IP. |
PAW561Bo01 | Polyclonal Antibody to Alpha-2-Plasmin Inhibitor (a2PI) | WB; IHC; ICC; IF. | |
Assay Kits | CLW561Bo01 | CLIA Kit for Alpha-2-Plasmin Inhibitor (a2PI) | CLIA assay for Antigen Detection |
ELW561Bo01 | ELISA Kit for Alpha-2-Plasmin Inhibitor (a2PI) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPW561Rb01 | Recombinant Alpha-2-Plasmin Inhibitor (a2PI) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAW561Rb01 | Monoclonal Antibody to Alpha-2-Plasmin Inhibitor (a2PI) | WB; IHC; ICC; IP. |
PAW561Rb01 | Polyclonal Antibody to Alpha-2-Plasmin Inhibitor (a2PI) | WB; IHC; ICC; IF. | |
Assay Kits | CLW561Rb01 | CLIA Kit for Alpha-2-Plasmin Inhibitor (a2PI) | CLIA assay for Antigen Detection |
ELW561Rb01 | ELISA Kit for Alpha-2-Plasmin Inhibitor (a2PI) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPW561Mo01 | Recombinant Alpha-2-Plasmin Inhibitor (a2PI) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAW561Mo01 | Monoclonal Antibody to Alpha-2-Plasmin Inhibitor (a2PI) | WB; IHC; ICC; IP. |
PAW561Mo01 | Polyclonal Antibody to Alpha-2-Plasmin Inhibitor (a2PI) | WB; IHC; ICC; IF. | |
Assay Kits | CLW561Mo01 | CLIA Kit for Alpha-2-Plasmin Inhibitor (a2PI) | CLIA assay for Antigen Detection |
ELW561Mo01 | ELISA Kit for Alpha-2-Plasmin Inhibitor (a2PI) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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Erratum
Proc. Natl. Acad. Sci. U.S.A. 86:1612-1613(1989)
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Science 241:699-700(1988) [PubMed] [Europe PMC] [Abstract]
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Blood 103:3783-3788(2004) [PubMed] [Europe PMC] [Abstract]
"Matriptase-3 is a novel phylogenetically preserved membrane-anchored serine protease with broad serpin reactivity."
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"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
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"Antiplasmin-cleaving enzyme is a soluble form of fibroblast activation protein."
Blood 107:1397-1404(2006) [PubMed] [Europe PMC] [Abstract]
"Hereditary alpha 2-plasmin inhibitor deficiency caused by a transport-deficient mutation (alpha 2-PI-Okinawa). Deletion of Glu137 by a trinucleotide deletion blocks intracellular transport."
J. Biol. Chem. 264:18213-18219(1989) [PubMed] [Europe PMC] [Abstract]
"A novel missense mutation in the human plasmin inhibitor (alpha2-antiplasmin) gene associated with a bleeding tendency."
Br. J. Haematol. 107:317-322(1999) [PubMed] [Europe PMC] [Abstract]