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Alpha-2-Plasmin Inhibitor (a2PI)

SERPINF2; AAP; A2-PI; API; PLI; A2AP; Alpha 2 Antiplasmin; Serpin Peptidase Inhibitor Clade F Member 2; Pigment Epithelium Derived Factor

An inherited hemorrhagic diathesis due to plasmin inhibitor deficiency was described by Koie et al. (1978) in a 25-year-old Okinawa man. He had suffered prolonged bleeding and ecchymoses after minor trauma, spontaneous joint hemorrhage, and one episode of hemothorax. The bleeding episodes were reduced in frequency and severity by an antiplasminic drug. Laboratory abnormalities were limited to shortened euglobulin-lysis time and whole blood clot lysis time. No circulating alpha-2-plasmin inhibitor was found in the plasma. Even though only one case was observed, autosomal recessive inheritance was undoubted because the parents were consanguineous and both had plasma antiplasmin levels about half normal. The authors called the condition Miyasato disease after the proband's surname.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW561Hu01 Recombinant Alpha-2-Plasmin Inhibitor (a2PI) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW561Hu01 Monoclonal Antibody to Alpha-2-Plasmin Inhibitor (a2PI) WB; IHC; ICC; IP.
PAW561Hu01 Polyclonal Antibody to Alpha-2-Plasmin Inhibitor (a2PI) WB; IHC; ICC; IF.
Assay Kits CLW561Hu01 CLIA Kit for Alpha-2-Plasmin Inhibitor (a2PI) CLIA assay for Antigen Detection
ELW561Hu01 ELISA Kit for Alpha-2-Plasmin Inhibitor (a2PI) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW561Mu01 Recombinant Alpha-2-Plasmin Inhibitor (a2PI) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW561Mu01 Monoclonal Antibody to Alpha-2-Plasmin Inhibitor (a2PI) WB; IHC; ICC; IP.
PAW561Mu01 Polyclonal Antibody to Alpha-2-Plasmin Inhibitor (a2PI) WB; IHC; ICC; IF.
Assay Kits CLW561Mu01 CLIA Kit for Alpha-2-Plasmin Inhibitor (a2PI) CLIA assay for Antigen Detection
ELW561Mu01 ELISA Kit for Alpha-2-Plasmin Inhibitor (a2PI) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW561Ra01 Recombinant Alpha-2-Plasmin Inhibitor (a2PI) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW561Ra01 Monoclonal Antibody to Alpha-2-Plasmin Inhibitor (a2PI) WB; IHC; ICC; IP.
PAW561Ra01 Polyclonal Antibody to Alpha-2-Plasmin Inhibitor (a2PI) WB; IHC; ICC; IF.
Assay Kits CLW561Ra01 CLIA Kit for Alpha-2-Plasmin Inhibitor (a2PI) CLIA assay for Antigen Detection
ELW561Ra01 ELISA Kit for Alpha-2-Plasmin Inhibitor (a2PI) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW561Ca01 Recombinant Alpha-2-Plasmin Inhibitor (a2PI) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW561Ca01 Monoclonal Antibody to Alpha-2-Plasmin Inhibitor (a2PI) WB; IHC; ICC; IP.
PAW561Ca01 Polyclonal Antibody to Alpha-2-Plasmin Inhibitor (a2PI) WB; IHC; ICC; IF.
Assay Kits CLW561Ca01 CLIA Kit for Alpha-2-Plasmin Inhibitor (a2PI) CLIA assay for Antigen Detection
ELW561Ca01 ELISA Kit for Alpha-2-Plasmin Inhibitor (a2PI) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW561Po01 Recombinant Alpha-2-Plasmin Inhibitor (a2PI) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW561Po01 Monoclonal Antibody to Alpha-2-Plasmin Inhibitor (a2PI) WB; IHC; ICC; IP.
PAW561Po01 Polyclonal Antibody to Alpha-2-Plasmin Inhibitor (a2PI) WB; IHC; ICC; IF.
Assay Kits CLW561Po01 CLIA Kit for Alpha-2-Plasmin Inhibitor (a2PI) CLIA assay for Antigen Detection
ELW561Po01 ELISA Kit for Alpha-2-Plasmin Inhibitor (a2PI) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW561Bo01 Recombinant Alpha-2-Plasmin Inhibitor (a2PI) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW561Bo01 Monoclonal Antibody to Alpha-2-Plasmin Inhibitor (a2PI) WB; IHC; ICC; IP.
PAW561Bo01 Polyclonal Antibody to Alpha-2-Plasmin Inhibitor (a2PI) WB; IHC; ICC; IF.
Assay Kits CLW561Bo01 CLIA Kit for Alpha-2-Plasmin Inhibitor (a2PI) CLIA assay for Antigen Detection
ELW561Bo01 ELISA Kit for Alpha-2-Plasmin Inhibitor (a2PI) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW561Rb01 Recombinant Alpha-2-Plasmin Inhibitor (a2PI) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW561Rb01 Monoclonal Antibody to Alpha-2-Plasmin Inhibitor (a2PI) WB; IHC; ICC; IP.
PAW561Rb01 Polyclonal Antibody to Alpha-2-Plasmin Inhibitor (a2PI) WB; IHC; ICC; IF.
Assay Kits CLW561Rb01 CLIA Kit for Alpha-2-Plasmin Inhibitor (a2PI) CLIA assay for Antigen Detection
ELW561Rb01 ELISA Kit for Alpha-2-Plasmin Inhibitor (a2PI) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW561Mo01 Recombinant Alpha-2-Plasmin Inhibitor (a2PI) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW561Mo01 Monoclonal Antibody to Alpha-2-Plasmin Inhibitor (a2PI) WB; IHC; ICC; IP.
PAW561Mo01 Polyclonal Antibody to Alpha-2-Plasmin Inhibitor (a2PI) WB; IHC; ICC; IF.
Assay Kits CLW561Mo01 CLIA Kit for Alpha-2-Plasmin Inhibitor (a2PI) CLIA assay for Antigen Detection
ELW561Mo01 ELISA Kit for Alpha-2-Plasmin Inhibitor (a2PI) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Structure of human alpha 2-plasmin inhibitor deduced from the cDNA sequence."
J. Biochem. 102:1033-1041(1987) [PubMed] [Europe PMC] [Abstract]

"Organization of the human alpha 2-plasmin inhibitor gene."
Proc. Natl. Acad. Sci. U.S.A. 85:6836-6840(1988) [PubMed] [Europe PMC] [Abstract]

Erratum
Proc. Natl. Acad. Sci. U.S.A. 86:1612-1613(1989)

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Primary structure of human alpha 2-antiplasmin, a serine protease inhibitor (serpin)."
J. Biol. Chem. 262:1659-1664(1987) [PubMed] [Europe PMC] [Abstract]

"Different N-terminal forms of alpha 2-plasmin inhibitor in human plasma."
Biochem. J. 291:623-625(1993) [PubMed] [Europe PMC] [Abstract]

"Bovine alpha 2-antiplasmin. N-terminal and reactive site sequence."
FEBS Lett. 312:100-104(1992) [PubMed] [Europe PMC] [Abstract]

"Amino-acid sequence of human alpha 2-antiplasmin."
Eur. J. Biochem. 166:565-574(1987) [PubMed] [Europe PMC] [Abstract]

"Purification and characterization of human antiplasmin, the fast-acting plasmin inhibitor in plasma."
Eur. J. Biochem. 78:19-26(1977) [PubMed] [Europe PMC] [Abstract]

"Structure of the carboxyl-terminal half of human alpha 2-plasmin inhibitor deduced from that of cDNA."
J. Biochem. 100:1399-1402(1986) [PubMed] [Europe PMC] [Abstract]

"Sulfation of a tyrosine residue in the plasmin-binding domain of alpha 2-antiplasmin."
J. Biol. Chem. 262:3082-3085(1987) [PubMed] [Europe PMC] [Abstract]

"Alpha-2-antiplasmin: a serpin with two separate but overlapping reactive sites."
Science 241:699-700(1988) [PubMed] [Europe PMC] [Abstract]

"Assignment of a single disulphide bridge in human alpha2-antiplasmin: implications for the structural and functional properties."
Biochem. J. 323:847-852(1997) [PubMed] [Europe PMC] [Abstract]

"A novel plasma proteinase potentiates alpha2-antiplasmin inhibition of fibrin digestion."
Blood 103:3783-3788(2004) [PubMed] [Europe PMC] [Abstract]

"Matriptase-3 is a novel phylogenetically preserved membrane-anchored serine protease with broad serpin reactivity."
Biochem. J. 390:231-242(2005) [PubMed] [Europe PMC] [Abstract]

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

"Antiplasmin-cleaving enzyme is a soluble form of fibroblast activation protein."
Blood 107:1397-1404(2006) [PubMed] [Europe PMC] [Abstract]

"Hereditary alpha 2-plasmin inhibitor deficiency caused by a transport-deficient mutation (alpha 2-PI-Okinawa). Deletion of Glu137 by a trinucleotide deletion blocks intracellular transport."
J. Biol. Chem. 264:18213-18219(1989) [PubMed] [Europe PMC] [Abstract]

"A novel missense mutation in the human plasmin inhibitor (alpha2-antiplasmin) gene associated with a bleeding tendency."
Br. J. Haematol. 107:317-322(1999) [PubMed] [Europe PMC] [Abstract]