Pepsinogen C (PGC)

PG-C; Progastricsin; Gastricsin

SPN	W557
HGNC	8890
MGI	98909
PubMed	14578117
RGD	3943
UniProt	P20142
Wiki	PGC_(gene

Pepsinogen, the inactive precursor of pepsin belongs to the group of aspartic proteinases, is synthesized in the chief cells of gastric glands. Seven electrophoretically separable pepsinogens exist in human gastric mucosa. One group, called PGA or group I pepsinogen, is characterized by electrophoretically faster migration and localization in the fundus and body of the stomach; the second group, termed pepsinogen C, is localized in the whole stomach. PGCs are found in prostate and in seminal fluid whereas PGAs are not. the absence of detectable immunologic crossreactivity between the pepsinogens A and C results from divergent evolution of sequences located on the surface of the zymogens in contrast to the strongly conserved active site regions located within the binding cleft of the enzymes, inaccessible for antigenic recognition.

Reference

"Primary structure of human pepsinogen C gene."
J. Biol. Chem. 263:1382-1385(1988) [PubMed] [Europe PMC] [Abstract]

Erratum
J. Biol. Chem. 263:14592-14592(1988)

"Human pepsinogen C (progastricsin). Isolation of cDNA clones, localization to chromosome 6, and sequence homology with pepsinogen A."
J. Biol. Chem. 264:375-379(1989) [PubMed] [Europe PMC] [Abstract]

"Human pepsinogen C (progastricsin) polymorphism: evidence for a single locus located at 6p21.1-pter."
Genomics 4:137-148(1989) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 6."
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"A comparative study on the NH2-terminal amino acid sequences and some other properties of six isozymic forms of human pepsinogens and pepsins."
J. Biochem. 106:920-927(1989) [PubMed] [Europe PMC] [Abstract]

"Human progastricsin. Analysis of intermediates during activation into gastricsin and determination of the amino acid sequence of the propart."
Eur. J. Biochem. 128:63-70(1982) [PubMed] [Europe PMC] [Abstract]

"Crystal and molecular structures of human progastricsin at 1.62-A resolution."
J. Mol. Biol. 247:466-485(1995) [PubMed] [Europe PMC] [Abstract]

"Structural characterization of activation 'intermediate 2' on the pathway to human gastricsin."
Nat. Struct. Biol. 4:1010-1015(1997) [PubMed] [Europe PMC] [Abstract]