Prostaglandin E Synthase, Microsomal (PTGES)
MGST1L1; MGST-IV; MGST1-L1; PGES; PIG12; PP102; PP1294; TP53I12; PGE Synthase; Tumor Protein p53 Inducible Protein 12; Glutathione S-Transferase 1-Like 1; MGST1-Like 1
Prostaglandin E synthase is an enzyme involved in eicosanoid and glutathione metabolism, a member of MAPEG family. It generates prostaglandin E (PGE) from prostaglandin H2.The synthase generating PGE2 is a membrane-associated protein. Prostaglandin E synthase is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis.The authors grouped the MGST1L1 protein with other members of the MAPEG (membrane-associated proteins in eicosanoid and glutathione metabolism) superfamily, which includes MGST2 , MGST3 , LTC4S, and FLAP (ALOX5AP).
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW556Hu01 | Recombinant Prostaglandin E Synthase, Microsomal (PTGES) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW556Hu01 | Monoclonal Antibody to Prostaglandin E Synthase, Microsomal (PTGES) | WB; IHC; ICC; IP. |
| PAW556Hu01 | Polyclonal Antibody to Prostaglandin E Synthase, Microsomal (PTGES) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW556Hu01 | CLIA Kit for Prostaglandin E Synthase, Microsomal (PTGES) | CLIA assay for Antigen Detection |
| ELW556Hu01 | ELISA Kit for Prostaglandin E Synthase, Microsomal (PTGES) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW556Mu01 | Recombinant Prostaglandin E Synthase, Microsomal (PTGES) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW556Mu01 | Monoclonal Antibody to Prostaglandin E Synthase, Microsomal (PTGES) | WB; IHC; ICC; IP. |
| PAW556Mu01 | Polyclonal Antibody to Prostaglandin E Synthase, Microsomal (PTGES) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW556Mu01 | CLIA Kit for Prostaglandin E Synthase, Microsomal (PTGES) | CLIA assay for Antigen Detection |
| ELW556Mu01 | ELISA Kit for Prostaglandin E Synthase, Microsomal (PTGES) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW556Ra01 | Recombinant Prostaglandin E Synthase, Microsomal (PTGES) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW556Ra01 | Monoclonal Antibody to Prostaglandin E Synthase, Microsomal (PTGES) | WB; IHC; ICC; IP. |
| PAW556Ra01 | Polyclonal Antibody to Prostaglandin E Synthase, Microsomal (PTGES) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW556Ra01 | CLIA Kit for Prostaglandin E Synthase, Microsomal (PTGES) | CLIA assay for Antigen Detection |
| ELW556Ra01 | ELISA Kit for Prostaglandin E Synthase, Microsomal (PTGES) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW556Ca01 | Recombinant Prostaglandin E Synthase, Microsomal (PTGES) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW556Ca01 | Monoclonal Antibody to Prostaglandin E Synthase, Microsomal (PTGES) | WB; IHC; ICC; IP. |
| PAW556Ca01 | Polyclonal Antibody to Prostaglandin E Synthase, Microsomal (PTGES) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW556Ca01 | CLIA Kit for Prostaglandin E Synthase, Microsomal (PTGES) | CLIA assay for Antigen Detection |
| ELW556Ca01 | ELISA Kit for Prostaglandin E Synthase, Microsomal (PTGES) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW556Po01 | Recombinant Prostaglandin E Synthase, Microsomal (PTGES) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW556Po01 | Monoclonal Antibody to Prostaglandin E Synthase, Microsomal (PTGES) | WB; IHC; ICC; IP. |
| PAW556Po01 | Polyclonal Antibody to Prostaglandin E Synthase, Microsomal (PTGES) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW556Po01 | CLIA Kit for Prostaglandin E Synthase, Microsomal (PTGES) | CLIA assay for Antigen Detection |
| ELW556Po01 | ELISA Kit for Prostaglandin E Synthase, Microsomal (PTGES) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW556Bo01 | Recombinant Prostaglandin E Synthase, Microsomal (PTGES) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW556Bo01 | Monoclonal Antibody to Prostaglandin E Synthase, Microsomal (PTGES) | WB; IHC; ICC; IP. |
| PAW556Bo01 | Polyclonal Antibody to Prostaglandin E Synthase, Microsomal (PTGES) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW556Bo01 | CLIA Kit for Prostaglandin E Synthase, Microsomal (PTGES) | CLIA assay for Antigen Detection |
| ELW556Bo01 | ELISA Kit for Prostaglandin E Synthase, Microsomal (PTGES) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW556Rb01 | Recombinant Prostaglandin E Synthase, Microsomal (PTGES) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW556Rb01 | Monoclonal Antibody to Prostaglandin E Synthase, Microsomal (PTGES) | WB; IHC; ICC; IP. |
| PAW556Rb01 | Polyclonal Antibody to Prostaglandin E Synthase, Microsomal (PTGES) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW556Rb01 | CLIA Kit for Prostaglandin E Synthase, Microsomal (PTGES) | CLIA assay for Antigen Detection |
| ELW556Rb01 | ELISA Kit for Prostaglandin E Synthase, Microsomal (PTGES) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW556Mo01 | Recombinant Prostaglandin E Synthase, Microsomal (PTGES) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW556Mo01 | Monoclonal Antibody to Prostaglandin E Synthase, Microsomal (PTGES) | WB; IHC; ICC; IP. |
| PAW556Mo01 | Polyclonal Antibody to Prostaglandin E Synthase, Microsomal (PTGES) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW556Mo01 | CLIA Kit for Prostaglandin E Synthase, Microsomal (PTGES) | CLIA assay for Antigen Detection |
| ELW556Mo01 | ELISA Kit for Prostaglandin E Synthase, Microsomal (PTGES) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"A model for p53-induced apoptosis."
Nature 389:300-306(1997) [PubMed] [Europe PMC] [Abstract]
"Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target."
Proc. Natl. Acad. Sci. U.S.A. 96:7220-7225(1999) [PubMed] [Europe PMC] [Abstract]
"Human glutathione dependent prostaglandin E synthase: gene structure and regulation."
FEBS Lett. 471:78-82(2000) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"DNA sequence and analysis of human chromosome 9."
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Purification and characterization of recombinant microsomal prostaglandin E synthase-1."
Protein Expr. Purif. 26:489-495(2002) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"Human microsomal prostaglandin E synthase-1: purification, functional characterization, and projection structure determination."
J. Biol. Chem. 278:22199-22209(2003) [PubMed] [Europe PMC] [Abstract]
"Structural basis for induced formation of the inflammatory mediator prostaglandin E2."
Proc. Natl. Acad. Sci. U.S.A. 105:11110-11115(2008) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of microsomal prostaglandin E2 synthase provides insight into diversity in the MAPEG superfamily."
Proc. Natl. Acad. Sci. U.S.A. 110:3806-3811(2013) [PubMed] [Europe PMC] [Abstract]