Acid Phosphatase 3, Prostatic (ACP3)

PSAP; ACPP; PAP; PAPf39; 5'-NT; Prostatic Specific Acid Phosphatase; Ecto-5'-Nucleotidase

SPN	W555
HGNC	125
MGI	1928480
PubMed	6995224
RGD	2023
UniProt	P15309
Wiki	ACP3

Prostatic acid phosphatase (PAP) is an enzyme produced by the prostate. It may be found in increased amounts in men who have prostate cancer or other diseases.The highest levels of acid phosphatase are found in metastasized prostate cancer. Diseases of the bone, such as Paget's disease or hyperparathyroidism, diseases of blood cells, such as sickle-cell disease or multiple myeloma or lysosomal storage diseases, such as Gaucher's disease, will show moderately increased levels.Certain medications can cause temporary increases or decreases in acid phosphatase levels. Manipulation of the prostate gland through massage, biopsy or rectal exam before a test may increase the level.Its physiological function may be associated with the liquefaction process of semen.

Reference

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Biochem. Biophys. Res. Commun. 184:1468-1476(1992) [PubMed] [Europe PMC] [Abstract]

"Covalent structure, disulfide bonding, and identification of reactive surface and active site residues of human prostatic acid phosphatase."
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"Human prostatic acid phosphatase: cDNA cloning, gene mapping and protein sequence homology with lysosomal acid phosphatase."
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"Molecular cloning and sequence analysis of cDNA encoding human prostatic acid phosphatase."
FEBS Lett. 236:275-281(1988) [PubMed] [Europe PMC] [Abstract]

"Nucleotide sequence of human prostatic acid phosphatase determined from a full-length cDNA clone."
Nucleic Acids Res. 18:4928-4928(1990) [PubMed] [Europe PMC] [Abstract]

"Nucleotide sequence of human prostatic acid phosphatase ACPP gene, including seven Alu repeats."
Biochem. Mol. Biol. Int. 33:561-565(1994) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence, annotation and analysis of human chromosome 3."
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Structures of the carbohydrate moieties of human prostatic acid phosphatase elucidated by H1 nuclear magnetic resonance spectroscopy."
Arch. Biochem. Biophys. 258:404-412(1987) [PubMed] [Europe PMC] [Abstract]

"Covalent modification and site-directed mutagenesis of an active site tryptophan of human prostatic acid phosphatase."
Acta Biochim. Pol. 44:659-672(1997) [PubMed] [Europe PMC] [Abstract]

"Prostatic acid phosphatase degrades lysophosphatidic acid in seminal plasma."
FEBS Lett. 571:197-204(2004) [PubMed] [Europe PMC] [Abstract]

"Prostatic acid phosphatase is not a prostate specific target."
Cancer Res. 67:6549-6554(2007) [PubMed] [Europe PMC] [Abstract]

"Semen-derived amyloid fibrils drastically enhance HIV infection."
Cell 131:1059-1071(2007) [PubMed] [Europe PMC] [Abstract]

"Integral and associated lysosomal membrane proteins."
Traffic 8:1676-1686(2007) [PubMed] [Europe PMC] [Abstract]

"Fibrils of prostatic acid phosphatase fragments boost infections with XMRV (xenotropic murine leukemia virus-related virus), a human retrovirus associated with prostate cancer."
J. Virol. 83:6995-7003(2009) [PubMed] [Europe PMC] [Abstract]

"The main green tea polyphenol epigallocatechin-3-gallate counteracts semen-mediated enhancement of HIV infection."
Proc. Natl. Acad. Sci. U.S.A. 106:9033-9038(2009) [PubMed] [Europe PMC] [Abstract]

"Aminoquinoline surfen inhibits the action of SEVI (semen-derived enhancer of viral infection)."
J. Biol. Chem. 285:1861-1869(2010) [PubMed] [Europe PMC] [Abstract]

"Human prostatic acid phosphatase, an authentic tyrosine phosphatase, dephosphorylates ErbB-2 and regulates prostate cancer cell growth."
J. Biol. Chem. 285:23598-23606(2010) [PubMed] [Europe PMC] [Abstract]

"Prostatic acid phosphatase expression in human tissues."
Int. J. Clin. Exp. Pathol. 4:295-306(2011) [PubMed] [Europe PMC] [Abstract]

"Structural origins of L(+)-tartrate inhibition of human prostatic acid phosphatase."
J. Biol. Chem. 273:30406-30409(1998) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of human prostatic acid phosphatase."
Prostate 42:211-218(2000) [PubMed] [Europe PMC] [Abstract]

"Crystal structures of human prostatic acid phosphatase in complex with a phosphate ion and alpha-benzylaminobenzylphosphonic acid update the mechanistic picture and offer new insights into inhibitor design."
Biochemistry 42:383-389(2003) [PubMed] [Europe PMC] [Abstract]

"NMR structure in a membrane environment reveals putative amyloidogenic regions of the SEVI precursor peptide PAP(248-286)."
J. Am. Chem. Soc. 131:17972-17979(2009) [PubMed] [Europe PMC] [Abstract]