Alanine Aminotransferase (ALT)

GPT; ALAT; SGPT; AAT1; GPT1; Serum Glutamic Pyruvic Transaminase; Alanine Transaminase; Glutamate pyruvate transaminase 1; Glutamic--alanine transaminase 1

SPN	W537
HGNC	4552
MGI	95802
PubMed	12529529
RGD	621720
UniProt	P24298
Wiki	ALT

Alanine transaminase or ALT is a transaminase enzyme. It is also called serum glutamic pyruvic transaminase (SGPT) or alanine aminotransferase (ALAT). ALT is found in serum and in various bodily tissues, but is most commonly associated with the liver. It catalyzes the transfer of an amino group from alanine to a-ketoglutarate, the products of this reversible transamination reaction being pyruvate and glutamate. It is commonly measured clinically as a part of a diagnostic liver function test, to determine liver health. GPT1 transcript is moderately expressed in kidney, liver, heart, and fat. Another GPT1 transcript shows a slightly different expression pattern, with a 3.9-kb transcript expressed at high levels in muscle, fat, kidney, and brain and at lower levels in liver and breast.

Reference

"Human glutamate pyruvate transaminase (GPT): localization to 8q24.3, cDNA and genomic sequences, and polymorphic sites."
Genomics 40:247-252(1997) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Complete amino acid sequence of human liver cytosolic alanine aminotransferase (GPT) determined by a combination of conventional and mass spectral methods."
Biochemistry 30:10451-10457(1991) [PubMed] [Europe PMC] [Abstract]

"cDNA cloning, genomic structure, chromosomal mapping, and functional expression of a novel human alanine aminotransferase."
Genomics 79:445-450(2002) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]