Matrix Metalloproteinase 23A (MMP23A)

CA-MMP; MMP23-A; MIFR; MIFR-1; MMP-21; Pseudogene; Femalysin; Matrix metalloproteinase-23, soluble form

SPN	W533
HGNC	7170
PubMed	9988691
UniProt	O75900

Matrix metalloproteinase 23a (MMP23a) lacks the signal sequence found in other MMPs, suggesting that it may function intracellularly. The substrate for the enzyme has not been identified, but it is thought that the protein may play a role in reproductive processes. The MMP23A gene is part of a duplicated region of chromosome 1p36.3, which includes a second gene, MMP23B, which is almost identical.

The matrix metalloproteinases are secreted glycoproteins that are involved in the remodeling of the extracellular matrix. By analysis of the genomic region surrounding the duplicated genes CDC2L1 and CDC2L2, Gururajan et al. (1998) identified 2 novel matrix metalloproteinase genes, MMP23A, which they called MMP21, and MMP23B , which they called MMP22.

Reference

"Isolation and characterization of two novel metalloproteinase genes linked to the Cdc2L locus on human chromosome 1p36.3."
Genomics 52:101-106(1998) [PubMed] [Europe PMC] [Abstract]

"Cloning and characterization of human MMP-23, a new matrix metalloproteinase predominantly expressed in reproductive tissues and lacking conserved domains in other family members."
J. Biol. Chem. 274:4570-4576(1999) [PubMed] [Europe PMC] [Abstract]

"Cloning and characterization of a rat ortholog of MMP-23 (matrix metalloproteinase-23), a unique type of membrane-anchored matrix metalloproteinase and conditioned switching of its expression during the ovarian follicular development."
Mol. Endocrinol. 15:747-764(2001) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]