Caveolin 1 (CAV1)
VIP21; Caveolae Protein 22kDa
The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade.
CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW530Hu01 | Recombinant Caveolin 1 (CAV1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW530Hu01 | Monoclonal Antibody to Caveolin 1 (CAV1) | WB; IHC; ICC; IP. |
| PAW530Hu01 | Polyclonal Antibody to Caveolin 1 (CAV1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW530Hu01 | CLIA Kit for Caveolin 1 (CAV1) | CLIA assay for Antigen Detection |
| ELW530Hu01 | ELISA Kit for Caveolin 1 (CAV1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW530Mu01 | Recombinant Caveolin 1 (CAV1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW530Mu01 | Monoclonal Antibody to Caveolin 1 (CAV1) | WB; IHC; ICC; IP. |
| PAW530Mu01 | Polyclonal Antibody to Caveolin 1 (CAV1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW530Mu01 | CLIA Kit for Caveolin 1 (CAV1) | CLIA assay for Antigen Detection |
| ELW530Mu01 | ELISA Kit for Caveolin 1 (CAV1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW530Ra01 | Recombinant Caveolin 1 (CAV1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW530Ra01 | Monoclonal Antibody to Caveolin 1 (CAV1) | WB; IHC; ICC; IP. |
| PAW530Ra01 | Polyclonal Antibody to Caveolin 1 (CAV1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW530Ra01 | CLIA Kit for Caveolin 1 (CAV1) | CLIA assay for Antigen Detection |
| ELW530Ra01 | ELISA Kit for Caveolin 1 (CAV1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW530Ca01 | Recombinant Caveolin 1 (CAV1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW530Ca01 | Monoclonal Antibody to Caveolin 1 (CAV1) | WB; IHC; ICC; IP. |
| PAW530Ca01 | Polyclonal Antibody to Caveolin 1 (CAV1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW530Ca01 | CLIA Kit for Caveolin 1 (CAV1) | CLIA assay for Antigen Detection |
| ELW530Ca01 | ELISA Kit for Caveolin 1 (CAV1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW530Po01 | Recombinant Caveolin 1 (CAV1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW530Po01 | Monoclonal Antibody to Caveolin 1 (CAV1) | WB; IHC; ICC; IP. |
| PAW530Po01 | Polyclonal Antibody to Caveolin 1 (CAV1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW530Po01 | CLIA Kit for Caveolin 1 (CAV1) | CLIA assay for Antigen Detection |
| ELW530Po01 | ELISA Kit for Caveolin 1 (CAV1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW530Bo01 | Recombinant Caveolin 1 (CAV1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW530Bo01 | Monoclonal Antibody to Caveolin 1 (CAV1) | WB; IHC; ICC; IP. |
| PAW530Bo01 | Polyclonal Antibody to Caveolin 1 (CAV1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW530Bo01 | CLIA Kit for Caveolin 1 (CAV1) | CLIA assay for Antigen Detection |
| ELW530Bo01 | ELISA Kit for Caveolin 1 (CAV1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW530Rb01 | Recombinant Caveolin 1 (CAV1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW530Rb01 | Monoclonal Antibody to Caveolin 1 (CAV1) | WB; IHC; ICC; IP. |
| PAW530Rb01 | Polyclonal Antibody to Caveolin 1 (CAV1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW530Rb01 | CLIA Kit for Caveolin 1 (CAV1) | CLIA assay for Antigen Detection |
| ELW530Rb01 | ELISA Kit for Caveolin 1 (CAV1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW530Mo01 | Recombinant Caveolin 1 (CAV1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW530Mo01 | Monoclonal Antibody to Caveolin 1 (CAV1) | WB; IHC; ICC; IP. |
| PAW530Mo01 | Polyclonal Antibody to Caveolin 1 (CAV1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW530Mo01 | CLIA Kit for Caveolin 1 (CAV1) | CLIA assay for Antigen Detection |
| ELW530Mo01 | ELISA Kit for Caveolin 1 (CAV1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"The sequence of human caveolin reveals identity with VIP21, a component of transport vesicles."
FEBS Lett. 314:45-48(1992) [PubMed] [Europe PMC] [Abstract]
"Analysis of the CAVEOLIN-1 gene at human chromosome 7q31.1 in primary tumours and tumour-derived cell lines."
Oncogene 18:1881-1890(1999) [PubMed] [Europe PMC] [Abstract]
"Sequence and detailed organization of the human caveolin-1 and -2 genes located near the D7S522 locus (7q31.1). Methylation of a CpG island in the 5' promoter region of the caveolin-1 gene in human breast cancer cell lines."
FEBS Lett. 448:221-230(1999) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"N-terminal processing and modifications of caveolin-1 in caveolae from human adipocytes."
Biochem. Biophys. Res. Commun. 320:480-486(2004) [PubMed] [Europe PMC] [Abstract]
"Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes."
Biochem. J. 383:237-248(2004) [PubMed] [Europe PMC] [Abstract]
"Phosphorylation of caveolin by src tyrosine kinases. The alpha-isoform of caveolin is selectively phosphorylated by v-Src in vivo."
J. Biol. Chem. 271:3863-3868(1996) [PubMed] [Europe PMC] [Abstract]
"Functional interaction of caveolin-1 with Bruton's tyrosine kinase and Bmx."
J. Biol. Chem. 277:9351-9357(2002) [PubMed] [Europe PMC] [Abstract]
"Identification and characterization of a novel human plant pathogenesis-related protein that localizes to lipid-enriched microdomains in the Golgi complex."
J. Cell Sci. 115:827-838(2002) [PubMed] [Europe PMC] [Abstract]
"c-Abl is required for oxidative stress-induced phosphorylation of caveolin-1 on tyrosine 14."
Cell. Signal. 15:289-298(2003) [PubMed] [Europe PMC] [Abstract]
"Translocation of endothelial nitric-oxide synthase involves a ternary complex with caveolin-1 and NOSTRIN."
Mol. Biol. Cell 17:3870-3880(2006) [PubMed] [Europe PMC] [Abstract]
"The rotavirus enterotoxin NSP4 directly interacts with the caveolar structural protein caveolin-1."
J. Virol. 80:2842-2854(2006) [PubMed] [Europe PMC] [Abstract]
"Caveolin-1 triggers T-cell activation via CD26 in association with CARMA1."
J. Biol. Chem. 282:10117-10131(2007) [PubMed] [Europe PMC] [Abstract]
"Association of a homozygous nonsense caveolin-1 mutation with Berardinelli-Seip congenital lipodystrophy."
J. Clin. Endocrinol. Metab. 93:1129-1134(2008) [PubMed] [Europe PMC] [Abstract]
"Heterozygous CAV1 frameshift mutations (MIM 601047) in patients with atypical partial lipodystrophy and hypertriglyceridemia."
Lipids Health Dis. 7:3-3(2008) [PubMed] [Europe PMC] [Abstract]
"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
"Large-scale proteomics analysis of the human kinome."
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
"Whole exome sequencing to identify a novel gene (caveolin-1) associated with human pulmonary arterial hypertension."
Circ. Cardiovasc. Genet. 5:336-343(2012) [PubMed] [Europe PMC] [Abstract]
"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"Caveolin-1 mutations (P132L and null) and the pathogenesis of breast cancer: caveolin-1 (P132L) behaves in a dominant-negative manner and caveolin-1 (-/-) null mice show mammary epithelial cell hyperplasia."
Am. J. Pathol. 161:1357-1369(2002) [PubMed] [Europe PMC] [Abstract]