Anti-Mullerian Hormone (AMH)

MIF; MIH; MIS; Müllerian Inhibiting Factor; Müllerian Inhibiting Hormone; Müllerian Inhibiting Substance

SPN	W518
HGNC	464
MGI	88006
PubMed	20407372
RGD	2108
UniProt	P03971
Wiki	AMH

Anti-Müllerian hormone (AMH) is a dimeric glycoprotein that inhibits the development of the Müllerian ducts in a male embryo. It is named after Johannes Peter Müller. AMH is a protein hormone structurally related to inhibin and activin, and a member of the transforming growth factor-β (TGF-β) family. It is present in fish, reptiles, birds, marsupials, and placental mammals.In mammals AMH is secreted by Sertoli cells of the testes during embryogenesis of the fetal male and prevents the development of the mullerian ducts into the uterus and other mullerian structures. The effect is ipsilateral, that is each testis suppresses Müllerian development only on its own side. In humans this action takes place by 8 weeks gestation. In female embryogenesis the absence of AMH allows for the development of upper vagina, uterus and cervix, and oviducts.

Reference

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Hum. Genet. 90:389-394(1992) [PubMed] [Europe PMC] [Abstract]

"Molecular genetics of the persistent Mullerian duct syndrome: a study of 19 families."
Hum. Mol. Genet. 3:125-131(1994) [PubMed] [Europe PMC] [Abstract]

"A 27 base-pair deletion of the anti-Muellerian type II receptor gene is the most common cause of the persistent Muellerian duct syndrome."
Hum. Mol. Genet. 5:1269-1277(1996) [PubMed] [Europe PMC] [Abstract]