Centromere Protein I (CENPI)

FSHPRH1; LRPR1; Mis6; ICEN19; Follicle-stimulating hormone primary response protein; Interphase centromere complex protein 19; Leucine-rich primary response protein 1

SPN	W515
HGNC	3968
MGI	2147897
PubMed	21888900
RGD	2631
UniProt	Q92674
Wiki	CENPI

Centromere protein I is involved in the response of gonadal tissues to follicle-stimulating hormone. This gene is also a potential candidate for human X-linked disorders of gonadal development and gametogenesis.By database searching with a sequence identified near the DRP2 gene on chromosome Xq22, Roberts et al. (1996) found that the sequence showed similarity to the rat LRPR1 gene. The deduced 756-amino acid human protein shares 72% sequence identity with the rat protein.Roberts et al. (1996) identified the LRPR1 gene on chromosome Xq22. They found by hybridization to YACs and to cosmids isolated from that region that LRPR1 is transcribed in a proximal-to-distal direction and lies approximately 40 kb proximal to DRP2, while BTK, the gene that is mutant in X-linked agammaglobulinemia, lies approximately 300 kb distal.

Reference

"Sequence and chromosomal location of a human homologue of LRPR1, an FSH primary response gene."
Genomics 37:122-124(1996) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of the human X chromosome."
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Human CENP-I specifies localization of CENP-F, MAD1 and MAD2 to kinetochores and is essential for mitosis."
Nat. Cell Biol. 5:341-345(2003) [PubMed] [Europe PMC] [Abstract]

"Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells."
Genes Cells 11:673-684(2006) [PubMed] [Europe PMC] [Abstract]

"The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres."
Nat. Cell Biol. 8:446-457(2006) [PubMed] [Europe PMC] [Abstract]

"The human CENP-A centromeric nucleosome-associated complex."
Nat. Cell Biol. 8:458-469(2006) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"The SUMO protease SENP6 is essential for inner kinetochore assembly."
J. Cell Biol. 188:681-692(2010) [PubMed] [Europe PMC] [Abstract]