Caspase 2 (CASP2)
ICH1L; NEDD2; ICH-1L/1S; Cysteinyl Aspartate Specific Proteinases 2; Apoptosis-Related Cysteine Peptidase; Neural Precursor Cell Expressed Developmentally Down-Regulated 2
Caspase 2 proteolytically cleaves other proteins. It belongs to a family of cysteine proteases called caspases that only cleave proteins at an amino acid following a aspartic acid residue. Within this family, caspase 2 is part of the Ich-1 subfamily. It is one of the most conserved caspases in different species of animal. Caspase 2 has a similar amino acid sequence to initiator caspases, including caspase 1, caspase 4, caspase 5 and caspase 9. It is produced as a zymogen, which contains a long pro-domain that is similar to that of caspase 9 and contains a protein interaction domain known as a CARD domain. Pro-caspase-2 contains two subunits, p19 and p12.In addition, caspase 2 may form a complex with the catalytic subunit of DNA-PK (DNA-PKcs) and PIDD (LRDD), which is involved in DNA repair after DNA damage.
Organism species: Homo sapiens (Human)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | W507Hu01 | Recombinant Caspase 2 (CASP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Caspase 2 (CASP2) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Caspase 2 (CASP2) | WB; IHC; ICC; IP. |
PW507Hu01 | Polyclonal Antibody to Caspase 2 (CASP2) | WB; IHC; ICC; IF. | |
LW507Hu71 | Biotin Linked-Polyclonal Antibody to Caspase 2 (CASP2) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Caspase 2 (CASP2) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Caspase 2 (CASP2) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Caspase 2 (CASP2) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Caspase 2 (CASP2) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Caspase 2 (CASP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Caspase 2 (CASP2) | CLIA assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Caspase 2 (CASP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Caspase 2 (CASP2) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Caspase 2 (CASP2) | WB; IHC; ICC; IP. |
PW507Mu01 | Polyclonal Antibody to Caspase 2 (CASP2) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Caspase 2 (CASP2) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Caspase 2 (CASP2) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Caspase 2 (CASP2) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Caspase 2 (CASP2) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Caspase 2 (CASP2) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Caspase 2 (CASP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Caspase 2 (CASP2) | CLIA assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Caspase 2 (CASP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Caspase 2 (CASP2) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Caspase 2 (CASP2) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Caspase 2 (CASP2) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Caspase 2 (CASP2) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Caspase 2 (CASP2) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Caspase 2 (CASP2) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Caspase 2 (CASP2) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Caspase 2 (CASP2) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Caspase 2 (CASP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Caspase 2 (CASP2) | CLIA assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Caspase 2 (CASP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Caspase 2 (CASP2) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Caspase 2 (CASP2) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Caspase 2 (CASP2) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Caspase 2 (CASP2) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Caspase 2 (CASP2) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Caspase 2 (CASP2) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Caspase 2 (CASP2) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Caspase 2 (CASP2) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Caspase 2 (CASP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Caspase 2 (CASP2) | CLIA assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Caspase 2 (CASP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Caspase 2 (CASP2) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Caspase 2 (CASP2) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Caspase 2 (CASP2) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Caspase 2 (CASP2) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Caspase 2 (CASP2) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Caspase 2 (CASP2) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Caspase 2 (CASP2) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Caspase 2 (CASP2) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Caspase 2 (CASP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Caspase 2 (CASP2) | CLIA assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Caspase 2 (CASP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Caspase 2 (CASP2) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Caspase 2 (CASP2) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Caspase 2 (CASP2) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Caspase 2 (CASP2) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Caspase 2 (CASP2) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Caspase 2 (CASP2) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Caspase 2 (CASP2) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Caspase 2 (CASP2) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Caspase 2 (CASP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Caspase 2 (CASP2) | CLIA assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Caspase 2 (CASP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Caspase 2 (CASP2) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Caspase 2 (CASP2) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Caspase 2 (CASP2) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Caspase 2 (CASP2) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Caspase 2 (CASP2) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Caspase 2 (CASP2) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Caspase 2 (CASP2) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Caspase 2 (CASP2) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Caspase 2 (CASP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Caspase 2 (CASP2) | CLIA assay for Antigen Detection |
Organism species: Chicken (Gallus)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Caspase 2 (CASP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Caspase 2 (CASP2) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Caspase 2 (CASP2) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Caspase 2 (CASP2) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Caspase 2 (CASP2) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Caspase 2 (CASP2) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Caspase 2 (CASP2) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Caspase 2 (CASP2) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Caspase 2 (CASP2) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Caspase 2 (CASP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Caspase 2 (CASP2) | CLIA assay for Antigen Detection |
Organism species: Ovis aries; Ovine (Sheep)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Caspase 2 (CASP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Caspase 2 (CASP2) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Caspase 2 (CASP2) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Caspase 2 (CASP2) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Caspase 2 (CASP2) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Caspase 2 (CASP2) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Caspase 2 (CASP2) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Caspase 2 (CASP2) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Caspase 2 (CASP2) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Caspase 2 (CASP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Caspase 2 (CASP2) | CLIA assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Caspase 2 (CASP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Caspase 2 (CASP2) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Caspase 2 (CASP2) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Caspase 2 (CASP2) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Caspase 2 (CASP2) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Caspase 2 (CASP2) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Caspase 2 (CASP2) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Caspase 2 (CASP2) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Caspase 2 (CASP2) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Caspase 2 (CASP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Caspase 2 (CASP2) | CLIA assay for Antigen Detection |
Organism species: Cavia (Guinea pig )
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Caspase 2 (CASP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Caspase 2 (CASP2) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Caspase 2 (CASP2) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Caspase 2 (CASP2) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Caspase 2 (CASP2) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Caspase 2 (CASP2) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Caspase 2 (CASP2) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Caspase 2 (CASP2) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Caspase 2 (CASP2) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Caspase 2 (CASP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Caspase 2 (CASP2) | CLIA assay for Antigen Detection |
Organism species: Equus caballus; Equine (Horse)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Caspase 2 (CASP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Caspase 2 (CASP2) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Caspase 2 (CASP2) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Caspase 2 (CASP2) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Caspase 2 (CASP2) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Caspase 2 (CASP2) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Caspase 2 (CASP2) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Caspase 2 (CASP2) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Caspase 2 (CASP2) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Caspase 2 (CASP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Caspase 2 (CASP2) | CLIA assay for Antigen Detection |
Organism species: Capra hircus; Caprine (Goat)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Caspase 2 (CASP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Caspase 2 (CASP2) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Caspase 2 (CASP2) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Caspase 2 (CASP2) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Caspase 2 (CASP2) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Caspase 2 (CASP2) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Caspase 2 (CASP2) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Caspase 2 (CASP2) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Caspase 2 (CASP2) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Caspase 2 (CASP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Caspase 2 (CASP2) | CLIA assay for Antigen Detection |
Organism species: Pan-species (General)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Caspase 2 (CASP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Caspase 2 (CASP2) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Caspase 2 (CASP2) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Caspase 2 (CASP2) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Caspase 2 (CASP2) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Caspase 2 (CASP2) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Caspase 2 (CASP2) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Caspase 2 (CASP2) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Caspase 2 (CASP2) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Caspase 2 (CASP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Caspase 2 (CASP2) | CLIA assay for Antigen Detection |
Reference
"Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death."
Cell 78:739-750(1994) [PubMed] [Europe PMC] [Abstract]
"Identification of a caspase-2 isoform that behaves as an endogenous inhibitor of the caspase cascade."
Cancer Res. 60:7039-7047(2000) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence of human chromosome 7."
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease."
Genes Dev. 10:1073-1083(1996) [PubMed] [Europe PMC] [Abstract]
"ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases."
Proc. Natl. Acad. Sci. U.S.A. 95:5156-5160(1998) [PubMed] [Europe PMC] [Abstract]
"The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress."
Science 304:843-846(2004) [PubMed] [Europe PMC] [Abstract]
"Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage."
Oncogene 25:5683-5692(2006) [PubMed] [Europe PMC] [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of caspase-2, apical initiator of the intrinsic apoptotic pathway."
J. Biol. Chem. 278:42441-42447(2003) [PubMed] [Europe PMC] [Abstract]