Transferrin Receptor 2 (TFR2)

HFE3; TFRC2

SPN	W497
HGNC	11762
MGI	1354956
PubMed	10802645
RGD	1310152
UniProt	Q9UP52
Wiki	TFR2

Transferrin receptor protein 2 is a protein that is encoded by the TFR2 gene. This gene is a member of the transferrin receptor-like family and encodes a single-pass type II membrane protein with a protease associated (PA) domain, an M28 peptidase domain and a transferrin receptor-like dimerization domain. This protein mediates cellular uptake of transferrin-bound iron and mutations in this gene have been associated with hereditary hemochromatosis type III. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.TFR2-alpha was expressed in the liver, spleen, lung, muscle, prostate, and peripheral blood mononuclear cells, whereas expression of TFR-beta was found in all tissues tested.

Reference

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