Integrin Alpha D (ITGaD)

CD11d; CD11-D; ITG-AD; ADB2; ITGA-D; CD11 antigen-like family member D; Leukointegrin alpha D

SPN	W489
HGNC	6146
MGI	3578624
PubMed	9598326
RGD	71075
UniProt	Q13349
Wiki	ITGAD

Three ITGs that share the beta-2 (CD18) subunit are restricted in expression to leukocytes and have homologous alpha subunits: alpha-L (ITGAL), alpha-M (ITGAM), and alpha-X (ITGAX). Wong designed degenerate PCR primers to identify novel leukocyte integrin alpha subunits. In this way they isolated a partial genomic clone encoding a new alpha subunit, designated ITGAD.

The ITGAD gene was found to be highly homologous to the 3 previously known alpha-subunit-encoding genes in deduced amino acid sequence, intron/exon structure, and chromosomal location. The ITGAD gene localize to 16p11.2.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Integrin Alpha D (ITGaD)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Integrin Alpha D (ITGaD)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Integrin Alpha D (ITGaD)	WB; IHC; ICC; IP.
	PW489Hu01	Polyclonal Antibody to Integrin Alpha D (ITGaD)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Integrin Alpha D (ITGaD)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Integrin Alpha D (ITGaD)	CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Integrin Alpha D (ITGaD)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Integrin Alpha D (ITGaD)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Integrin Alpha D (ITGaD)	WB; IHC; ICC; IP.
	PW489Mu01	Polyclonal Antibody to Integrin Alpha D (ITGaD)	WB; IHC; ICC; IF.
	LW489Mu71	Biotin Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Integrin Alpha D (ITGaD)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Integrin Alpha D (ITGaD)	CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	W489Ra01	Recombinant Integrin Alpha D (ITGaD)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Integrin Alpha D (ITGaD)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Integrin Alpha D (ITGaD)	WB; IHC; ICC; IP.
	PW489Ra01	Polyclonal Antibody to Integrin Alpha D (ITGaD)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Integrin Alpha D (ITGaD)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Integrin Alpha D (ITGaD)	CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Integrin Alpha D (ITGaD)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Integrin Alpha D (ITGaD)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Integrin Alpha D (ITGaD)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Integrin Alpha D (ITGaD)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Integrin Alpha D (ITGaD)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Integrin Alpha D (ITGaD)	CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Integrin Alpha D (ITGaD)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Integrin Alpha D (ITGaD)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Integrin Alpha D (ITGaD)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Integrin Alpha D (ITGaD)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Integrin Alpha D (ITGaD)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Integrin Alpha D (ITGaD)	CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Integrin Alpha D (ITGaD)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Integrin Alpha D (ITGaD)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Integrin Alpha D (ITGaD)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Integrin Alpha D (ITGaD)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Integrin Alpha D (ITGaD)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Integrin Alpha D (ITGaD)	CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Integrin Alpha D (ITGaD)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Integrin Alpha D (ITGaD)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Integrin Alpha D (ITGaD)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Integrin Alpha D (ITGaD)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Integrin Alpha D (ITGaD)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Integrin Alpha D (ITGaD)	CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Integrin Alpha D (ITGaD)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Integrin Alpha D (ITGaD)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Integrin Alpha D (ITGaD)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Integrin Alpha D (ITGaD)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Integrin Alpha D (ITGaD)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Integrin Alpha D (ITGaD)	CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Integrin Alpha D (ITGaD)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Integrin Alpha D (ITGaD)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Integrin Alpha D (ITGaD)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Integrin Alpha D (ITGaD)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Integrin Alpha D (ITGaD)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Integrin Alpha D (ITGaD)	CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Integrin Alpha D (ITGaD)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Integrin Alpha D (ITGaD)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Integrin Alpha D (ITGaD)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Integrin Alpha D (ITGaD)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Integrin Alpha D (ITGaD)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Integrin Alpha D (ITGaD)	CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Integrin Alpha D (ITGaD)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Integrin Alpha D (ITGaD)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Integrin Alpha D (ITGaD)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Integrin Alpha D (ITGaD)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Integrin Alpha D (ITGaD)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Integrin Alpha D (ITGaD)	CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Integrin Alpha D (ITGaD)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Integrin Alpha D (ITGaD)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Integrin Alpha D (ITGaD)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Integrin Alpha D (ITGaD)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Integrin Alpha D (ITGaD)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Integrin Alpha D (ITGaD)	CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Integrin Alpha D (ITGaD)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Integrin Alpha D (ITGaD)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Integrin Alpha D (ITGaD)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Integrin Alpha D (ITGaD)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Integrin Alpha D (ITGaD)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Integrin Alpha D (ITGaD)	CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Integrin Alpha D (ITGaD)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Integrin Alpha D (ITGaD)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Integrin Alpha D (ITGaD)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Integrin Alpha D (ITGaD)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Integrin Alpha D (ITGaD)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Integrin Alpha D (ITGaD)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Integrin Alpha D (ITGaD)	CLIA assay for Antigen Detection

Reference

"A novel leukointegrin, alpha d beta 2, binds preferentially to ICAM-3."
Immunity 3:683-690(1995) [PubMed] [Europe PMC] [Abstract]

"Structural and functional characterization of the leukocyte integrin gene CD11d. Essential role of Sp1 and Sp3."
J. Biol. Chem. 275:8959-8969(2000) [PubMed] [Europe PMC] [Abstract]

"Cloning and chromosomal localization of a novel gene-encoding a human beta 2-integrin alpha subunit."
Gene 171:291-294(1996) [PubMed] [Europe PMC] [Abstract]

"Alphadbeta2 integrin is expressed on human eosinophils and functions as an alternative ligand for vascular cell adhesion molecule 1 (VCAM-1)."
J. Exp. Med. 188:2187-2191(1998) [PubMed] [Europe PMC] [Abstract]

"The leukocyte integrin alpha D beta 2 binds VCAM-1: evidence for a binding interface between I domain and VCAM-1."
J. Immunol. 163:1984-1990(1999) [PubMed] [Europe PMC] [Abstract]