B-Cell Activation Factor Receptor (BAFFR)
CD268; TNFRSF13C; TNFRSF13-C; BAFF-R; BAFFR; BR3; Tumor Necrosis Factor Receptor Superfamily Member 13C
BAFF receptor is a recently identified molecule that specifically binds BLyS, a protein belonging to the tumor necrosis factor (TNF) family, and is involved in survival and maturation of B cells. Recent studies have demonstrated that mice defective in BAFF-R gene exhibit an altered profile of the B cell pool, a phenotype observed in BLyS knockout mice as well. These features suggest that mutations in this gene may result in humoral immunodeficiency.
B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW481Hu01 | Recombinant B-Cell Activation Factor Receptor (BAFFR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW481Hu01 | Monoclonal Antibody to B-Cell Activation Factor Receptor (BAFFR) | WB; IHC; ICC; IP. |
| PAW481Hu01 | Polyclonal Antibody to B-Cell Activation Factor Receptor (BAFFR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW481Hu01 | CLIA Kit for B-Cell Activation Factor Receptor (BAFFR) | CLIA assay for Antigen Detection |
| ELW481Hu01 | ELISA Kit for B-Cell Activation Factor Receptor (BAFFR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW481Mu01 | Recombinant B-Cell Activation Factor Receptor (BAFFR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW481Mu01 | Monoclonal Antibody to B-Cell Activation Factor Receptor (BAFFR) | WB; IHC; ICC; IP. |
| PAW481Mu01 | Polyclonal Antibody to B-Cell Activation Factor Receptor (BAFFR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW481Mu01 | CLIA Kit for B-Cell Activation Factor Receptor (BAFFR) | CLIA assay for Antigen Detection |
| ELW481Mu01 | ELISA Kit for B-Cell Activation Factor Receptor (BAFFR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW481Ra01 | Recombinant B-Cell Activation Factor Receptor (BAFFR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW481Ra01 | Monoclonal Antibody to B-Cell Activation Factor Receptor (BAFFR) | WB; IHC; ICC; IP. |
| PAW481Ra01 | Polyclonal Antibody to B-Cell Activation Factor Receptor (BAFFR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW481Ra01 | CLIA Kit for B-Cell Activation Factor Receptor (BAFFR) | CLIA assay for Antigen Detection |
| ELW481Ra01 | ELISA Kit for B-Cell Activation Factor Receptor (BAFFR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW481Ca01 | Recombinant B-Cell Activation Factor Receptor (BAFFR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW481Ca01 | Monoclonal Antibody to B-Cell Activation Factor Receptor (BAFFR) | WB; IHC; ICC; IP. |
| PAW481Ca01 | Polyclonal Antibody to B-Cell Activation Factor Receptor (BAFFR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW481Ca01 | CLIA Kit for B-Cell Activation Factor Receptor (BAFFR) | CLIA assay for Antigen Detection |
| ELW481Ca01 | ELISA Kit for B-Cell Activation Factor Receptor (BAFFR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW481Po01 | Recombinant B-Cell Activation Factor Receptor (BAFFR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW481Po01 | Monoclonal Antibody to B-Cell Activation Factor Receptor (BAFFR) | WB; IHC; ICC; IP. |
| PAW481Po01 | Polyclonal Antibody to B-Cell Activation Factor Receptor (BAFFR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW481Po01 | CLIA Kit for B-Cell Activation Factor Receptor (BAFFR) | CLIA assay for Antigen Detection |
| ELW481Po01 | ELISA Kit for B-Cell Activation Factor Receptor (BAFFR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW481Bo01 | Recombinant B-Cell Activation Factor Receptor (BAFFR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW481Bo01 | Monoclonal Antibody to B-Cell Activation Factor Receptor (BAFFR) | WB; IHC; ICC; IP. |
| PAW481Bo01 | Polyclonal Antibody to B-Cell Activation Factor Receptor (BAFFR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW481Bo01 | CLIA Kit for B-Cell Activation Factor Receptor (BAFFR) | CLIA assay for Antigen Detection |
| ELW481Bo01 | ELISA Kit for B-Cell Activation Factor Receptor (BAFFR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW481Rb01 | Recombinant B-Cell Activation Factor Receptor (BAFFR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW481Rb01 | Monoclonal Antibody to B-Cell Activation Factor Receptor (BAFFR) | WB; IHC; ICC; IP. |
| PAW481Rb01 | Polyclonal Antibody to B-Cell Activation Factor Receptor (BAFFR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW481Rb01 | CLIA Kit for B-Cell Activation Factor Receptor (BAFFR) | CLIA assay for Antigen Detection |
| ELW481Rb01 | ELISA Kit for B-Cell Activation Factor Receptor (BAFFR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW481Mo01 | Recombinant B-Cell Activation Factor Receptor (BAFFR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW481Mo01 | Monoclonal Antibody to B-Cell Activation Factor Receptor (BAFFR) | WB; IHC; ICC; IP. |
| PAW481Mo01 | Polyclonal Antibody to B-Cell Activation Factor Receptor (BAFFR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW481Mo01 | CLIA Kit for B-Cell Activation Factor Receptor (BAFFR) | CLIA assay for Antigen Detection |
| ELW481Mo01 | ELISA Kit for B-Cell Activation Factor Receptor (BAFFR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF."
Science 293:2108-2111(2001) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence of human chromosome 22."
Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
"Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency."
Curr. Biol. 11:1547-1552(2001) [PubMed] [Europe PMC] [Abstract]
"BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2."
Immunity 17:515-524(2002) [PubMed] [Europe PMC] [Abstract]
"BAFF/BLyS receptor 3 comprises a minimal TNF receptor-like module that encodes a highly focused ligand-binding site."
Biochemistry 42:5977-5983(2003) [PubMed] [Europe PMC] [Abstract]
"Ligand-receptor binding revealed by the TNF family member TALL-1."
Nature 423:49-56(2003) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of the BAFF-BAFF-R complex and its implications for receptor activation."
Nat. Struct. Biol. 10:342-348(2003) [PubMed] [Europe PMC] [Abstract]
"Synthetic anti-BR3 antibodies that mimic BAFF binding and target both human and murine B cells."
Blood 108:3103-3111(2006) [PubMed] [Europe PMC] [Abstract]
"Mutational analysis of human BAFF receptor TNFRSF13C (BAFF-R) in patients with common variable immunodeficiency."
J. Clin. Immunol. 25:496-502(2005) [PubMed] [Europe PMC] [Abstract]
"B-cell activating factor receptor deficiency is associated with an adult-onset antibody deficiency syndrome in humans."
Proc. Natl. Acad. Sci. U.S.A. 106:13945-13950(2009) [PubMed] [Europe PMC] [Abstract]