Heparin Cofactor II (HCII)
SERPIND1; HC2; HCF2; HC II; HLS2; LS2; Serpin D1; Serpin Peptidase Inhibitor Clade D Member 1; Protease inhibitor leuserpin-2
Heparin cofactor II, a protein encoded by the SERPIND1 gene, is a coagulation factor that inhibits IIa, and is a cofactor for heparin and dermatan sulfate ("minor antithrombin").
The product encoded by this gene is a serine proteinase inhibitor which rapidly inhibits thrombin in the presence of dermatan sulfate or heparin. The gene contains five exons and four introns.
This protein shares homology with antithrombin III and other members of the alpha 1-antitrypsin superfamily. Mutations in this gene are associated with heparin cofactor II deficiency. Heparin Cofactor II deficiency can lead to increased thrombin generation and a hypercoagulable state.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW478Hu01 | Recombinant Heparin Cofactor II (HCII) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW478Hu01 | Monoclonal Antibody to Heparin Cofactor II (HCII) | WB; IHC; ICC; IP. |
| PAW478Hu01 | Polyclonal Antibody to Heparin Cofactor II (HCII) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW478Hu01 | CLIA Kit for Heparin Cofactor II (HCII) | CLIA assay for Antigen Detection |
| ELW478Hu01 | ELISA Kit for Heparin Cofactor II (HCII) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW478Mu01 | Recombinant Heparin Cofactor II (HCII) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW478Mu01 | Monoclonal Antibody to Heparin Cofactor II (HCII) | WB; IHC; ICC; IP. |
| PAW478Mu01 | Polyclonal Antibody to Heparin Cofactor II (HCII) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW478Mu01 | CLIA Kit for Heparin Cofactor II (HCII) | CLIA assay for Antigen Detection |
| ELW478Mu01 | ELISA Kit for Heparin Cofactor II (HCII) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW478Ra01 | Recombinant Heparin Cofactor II (HCII) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW478Ra01 | Monoclonal Antibody to Heparin Cofactor II (HCII) | WB; IHC; ICC; IP. |
| PAW478Ra01 | Polyclonal Antibody to Heparin Cofactor II (HCII) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW478Ra01 | CLIA Kit for Heparin Cofactor II (HCII) | CLIA assay for Antigen Detection |
| ELW478Ra01 | ELISA Kit for Heparin Cofactor II (HCII) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW478Ca01 | Recombinant Heparin Cofactor II (HCII) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW478Ca01 | Monoclonal Antibody to Heparin Cofactor II (HCII) | WB; IHC; ICC; IP. |
| PAW478Ca01 | Polyclonal Antibody to Heparin Cofactor II (HCII) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW478Ca01 | CLIA Kit for Heparin Cofactor II (HCII) | CLIA assay for Antigen Detection |
| ELW478Ca01 | ELISA Kit for Heparin Cofactor II (HCII) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW478Po01 | Recombinant Heparin Cofactor II (HCII) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW478Po01 | Monoclonal Antibody to Heparin Cofactor II (HCII) | WB; IHC; ICC; IP. |
| PAW478Po01 | Polyclonal Antibody to Heparin Cofactor II (HCII) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW478Po01 | CLIA Kit for Heparin Cofactor II (HCII) | CLIA assay for Antigen Detection |
| ELW478Po01 | ELISA Kit for Heparin Cofactor II (HCII) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW478Bo01 | Recombinant Heparin Cofactor II (HCII) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW478Bo01 | Monoclonal Antibody to Heparin Cofactor II (HCII) | WB; IHC; ICC; IP. |
| PAW478Bo01 | Polyclonal Antibody to Heparin Cofactor II (HCII) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW478Bo01 | CLIA Kit for Heparin Cofactor II (HCII) | CLIA assay for Antigen Detection |
| ELW478Bo01 | ELISA Kit for Heparin Cofactor II (HCII) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW478Rb01 | Recombinant Heparin Cofactor II (HCII) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW478Rb01 | Monoclonal Antibody to Heparin Cofactor II (HCII) | WB; IHC; ICC; IP. |
| PAW478Rb01 | Polyclonal Antibody to Heparin Cofactor II (HCII) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW478Rb01 | CLIA Kit for Heparin Cofactor II (HCII) | CLIA assay for Antigen Detection |
| ELW478Rb01 | ELISA Kit for Heparin Cofactor II (HCII) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW478Mo01 | Recombinant Heparin Cofactor II (HCII) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW478Mo01 | Monoclonal Antibody to Heparin Cofactor II (HCII) | WB; IHC; ICC; IP. |
| PAW478Mo01 | Polyclonal Antibody to Heparin Cofactor II (HCII) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW478Mo01 | CLIA Kit for Heparin Cofactor II (HCII) | CLIA assay for Antigen Detection |
| ELW478Mo01 | ELISA Kit for Heparin Cofactor II (HCII) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Heparin cofactor II: cDNA sequence, chromosome localization, restriction fragment length polymorphism, and expression in Escherichia coli."
Biochemistry 27:752-759(1988) [PubMed] [Europe PMC] [Abstract]
"Complete nucleotide sequence of the gene for human heparin cofactor II and mapping to chromosomal band 22q11."
Biochemistry 30:1350-1357(1991) [PubMed] [Europe PMC] [Abstract]
"A genome annotation-driven approach to cloning the human ORFeome."
Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
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Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
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Nucleic Acids Res. 14:1073-1088(1986) [PubMed] [Europe PMC] [Abstract]
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Biochem. Biophys. Res. Commun. 137:431-436(1986) [PubMed] [Europe PMC] [Abstract]
"Structural evidence for leucine at the reactive site of heparin cofactor II."
Biochemistry 24:6777-6782(1985) [PubMed] [Europe PMC] [Abstract]
"Structure and expression of the gene coding for the human serpin hLS2."
J. Biol. Chem. 263:12129-12134(1988) [PubMed] [Europe PMC] [Abstract]
"Leukocyte chemoattractant peptides from the serpin heparin cofactor II."
J. Biol. Chem. 266:704-709(1991) [PubMed] [Europe PMC] [Abstract]
"The N-terminal acidic domain of heparin cofactor II mediates the inhibition of alpha-thrombin in the presence of glycosaminoglycans."
J. Biol. Chem. 266:20223-20231(1991) [PubMed] [Europe PMC] [Abstract]
"Site-directed mutagenesis of arginine 103 and lysine 185 in the proposed glycosaminoglycan-binding site of heparin cofactor II."
J. Biol. Chem. 265:286-291(1990) [PubMed] [Europe PMC] [Abstract]
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
"A strategy for precise and large scale identification of core fucosylated glycoproteins."
Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
"Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism."
Proc. Natl. Acad. Sci. U.S.A. 99:11079-11084(2002) [PubMed] [Europe PMC] [Abstract]
"Heparin cofactor IIOslo. Mutation of Arg-189 to His decreases the affinity for dermatan sulfate."
J. Biol. Chem. 264:5128-5133(1989) [PubMed] [Europe PMC] [Abstract]
"Characterization of single-nucleotide polymorphisms in coding regions of human genes."
Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]
Erratum
Nat. Genet. 23:373-373(1999)
"Molecular mechanism of type I congenital heparin cofactor (HC) II deficiency caused by a missense mutation at reactive P2 site: HC II Tokushima."
Thromb. Haemost. 85:101-107(2001) [PubMed] [Europe PMC] [Abstract]
"Homozygous deficiency of heparin cofactor II: relevance of P17 glutamate residue in serpins, relationship with conformational diseases, and role in thrombosis."
Circulation 110:1303-1307(2004) [PubMed] [Europe PMC] [Abstract]